Aging-related epigenetic changes - Revision history

Dmitry Dzhagarov: /* Aging-related epigenetic changes, their impacts on gene expression, and the functional consequences thereof */

2024-08-07T16:34:52Z

Aging-related epigenetic changes, their impacts on gene expression, and the functional consequences thereof

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 == References ==

Dmitry Dzhagarov: /* Aging-related epigenetic changes, their impacts on gene expression, and the functional consequences thereof */

2024-02-22T13:46:11Z

Aging-related epigenetic changes, their impacts on gene expression, and the functional consequences thereof

← Older revision		Revision as of 13:46, 22 February 2024
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			== References ==
			<references />
			[[Category:Main list]]
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			[[Category:Aging pathways and hallmarks]]

Dmitry Dzhagarov: /* Aging-related epigenetic changes, their impacts on gene expression, and the functional consequences thereof */

2024-02-22T13:40:42Z

Aging-related epigenetic changes, their impacts on gene expression, and the functional consequences thereof

← Older revision		Revision as of 13:40, 22 February 2024
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	(According to Wu et al., 2024<ref>Wu, Z., Zhang, W., Qu, J., & Liu, G. H. (2024). Emerging epigenetic insights into aging mechanisms and interventions. Trends in Pharmacological Sciences. PMID: 38216430 [https://doi.org/10.1016/j.tips.2023.12.002 DOI: 10.1016/j.tips.2023.12.002]</ref>)		(According to Wu et al., 2024<ref>Wu, Z., Zhang, W., Qu, J., & Liu, G. H. (2024). Emerging epigenetic insights into aging mechanisms and interventions. Trends in Pharmacological Sciences. PMID: 38216430 [https://doi.org/10.1016/j.tips.2023.12.002 DOI: 10.1016/j.tips.2023.12.002]</ref>)
	{\| class="wikitable"		{\| class="wikitable"
	\|+ ~~Caption text~~		\|+ Abbreviations: Aβ, amyloid β; APP, amyloid precursor protein; BACE1, beta-site APP cleaving enzyme 1; cGAS, cyclic GMP-AMP synthase; CYP1B1, cytochrome P450 family 1 subfamily B member 1; ERK, extracellular signal-regulated kinase; ERV, endogenous retrovirus; FASN, fatty acid synthase; IFN, interferon; LAD, lamina-associated domain; LINE-1, long-interspersed element-1; MAPK, mitogen-activated protein kinase; MMP13, matrix metalloproteinase 13; MSC, mesenchymal stem cell; OA, osteoarthritis; PSG, pregnancy-specific beta-1 glycoprotein; SASP, senescence-associated secretory phenotype; STING, stimulator of interferon genes.
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	! '''Epigenetic change''' !! Gene expression!! Functional consequence !! Refs		! '''Epigenetic change''' !! Gene expression!! Functional consequence !! Refs
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	\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~		\| Increased histone acetylation \|\| Upregulated p16 and p53 \|\| Accelerated senescence of human cancer cells \|\| <ref>Wang L. et al. Exploiting senescence for the treatment of cancer. Nat. Rev. Cancer. 2022; 22: 340-355</ref>
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	\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~		\| \|\| \|\| \|\|
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			\| Increased miR-145 \|\| Downregulated semaphorin-3A \|\| Alleviation of heart aging \|\| <ref>Wagner J.U.G.et al.Aging impairs the neurovascular interface in the heart. Science. 2023; 381: 897-906</ref>
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			\| Increased miR-31 \|\| Repression of CLOCK and activation of MAPK/ERK signaling \|\| Accelerated skin aging \|\| <ref>Yu Y.et al. A stress-induced miR-31-CLOCK-ERK pathway is a key driver and therapeutic target for skin aging. Nat. Aging. 2021; 1: 795-809</ref>
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	\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~		\| \|\| \|\| \|\|
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	\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~		\| Increased RNA m<sup>5</sup>C \|\| Repressed cGAS-STING activity \|\| Decreased IFN-β \|\| <ref>Chen T. et al. NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance. Cell Metab. 2023; 35: 1782-1798</ref>
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	\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~		\| \|\| \|\| \|\|
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	\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~		\| Increased RNA m<sup>6</sup>A \|\| Downregulated CDKN1C (p57) \|\| Alleviated MSC senescence, improved MSC survival and angiogenesis, and enhanced cardioprotective effect against myocardial infarction in mice \|\| <ref>Gao X. et al. Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction. FASEB J. 2023; 37e23294</ref>
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	\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~		\| \|\| Upregulated CYP1B1 \|\| Accelerated human MSC aging and onset of OA in mice \|\| <ref>Ye G.et al. ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression. Exp. Mol. Med. 2023; 55: 1743-1756</ref>
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	\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~		\| \|\| \|\| \|\|
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	\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~ \|\| ~~Example~~		\| Increased RNA m<sup>6</sup>A and m<sup>5</sup>C \|\| Upregulated p21 \|\| Oxidative stress-induced senescence of human cancer cells \|\| <ref>Li Q.
			et al. NSUN2-mediated m5C methylation and METTL3/METTL14-mediated m6A methylation cooperatively enhance p21 translation. J. Cell. Biochem. 2017; 118: 2587-2598</ref>
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	~~\| Example \|\| Example \|\| Example \|\| Example~~
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Dmitry Dzhagarov: /* Aging-related epigenetic changes, their impacts on gene expression, and the functional consequences thereof */

2024-02-22T12:57:55Z

Aging-related epigenetic changes, their impacts on gene expression, and the functional consequences thereof

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+| Decreased DNA 5mC || Upregulated ''CDKN2A'' (p16) || Accelerated senescence of human cancer cells || <ref>Wang L.
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+| Increased H3K14ac || Upregulated CDKN2B (p15) || Accelerated human MSC senescence || <ref>Wang W. et al. A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence. Sci. Transl. Med. 2021; 13eabd2655</ref>
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+| Increased H3K27ac and H3K4me1 || Upregulated HMGB2 || Rejuvenation of senescent human MSCs and alleviation of OA in aged mice || <ref>Jing Y.
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+| Increased H3K27ac and H3K9ac || Upregulated Aβ || Progression of AD-related degeneration || <ref>Nativio R. et al.An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease. Nat. Genet. 2020; 52: 1024-1035</ref>
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+| Increased H3K4me3 || Upregulated p21 || Accelerated human MSC senescence || <ref>Yan K. et al. SGF29 nuclear condensates reinforce cellular aging. Cell Discov. 2023; 9: 110</ref>
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Dmitry Dzhagarov: Created page with "Epigenetics, a rapidly evolving field, refers to the study of modifications to gene expression that does not alter the DNA sequence. Epigenetic dysregulation is both a hallmark and a driver of aging and restoring epigenetic integrity can reverse aging phenotypes.Pereira, B., Correia, F. P., Alves, I. A., Costa, M., Gameiro, M., Martins, A. P., & Saraiva, J. A. (2024). Epigenetic Reprogramming as a Key to Reverse Ageing and Increase Longevity. Ageing Research Reviews..."

2024-02-22T09:07:38Z

Created page with "Epigenetics, a rapidly evolving field, refers to the study of modifications to gene expression that does not alter the DNA sequence. Epigenetic dysregulation is both a hallmark and a driver of aging and restoring epigenetic integrity can reverse aging phenotypes.<ref>Pereira, B., Correia, F. P., Alves, I. A., Costa, M., Gameiro, M., Martins, A. P., & Saraiva, J. A. (2024). Epigenetic Reprogramming as a Key to Reverse Ageing and Increase Longevity. Ageing Research Reviews..."

New page

Epigenetics, a rapidly evolving field, refers to the study of modifications to gene expression that does not alter the DNA sequence. Epigenetic dysregulation is both a hallmark and a driver of aging and restoring epigenetic integrity can reverse aging phenotypes.<ref>Pereira, B., Correia, F. P., Alves, I. A., Costa, M., Gameiro, M., Martins, A. P., & Saraiva, J. A. (2024). Epigenetic Reprogramming as a Key to Reverse Ageing and Increase Longevity. Ageing Research Reviews, 102204. PMID: 38272265 [https://doi.org/10.1016/j.arr.2024.102204 DOI: 10.1016/j.arr.2024.102204]</ref>
== Aging-related epigenetic changes, their impacts on gene expression, and the functional consequences thereof ==
(According to Wu et al., 2024<ref>Wu, Z., Zhang, W., Qu, J., & Liu, G. H. (2024). Emerging epigenetic insights into aging mechanisms and interventions. Trends in Pharmacological Sciences. PMID: 38216430 [https://doi.org/10.1016/j.tips.2023.12.002 DOI: 10.1016/j.tips.2023.12.002]</ref>)
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