Fisetin - Revision history

Dmitry Dzhagarov: /* Evidence of lifespan extension */

2023-04-15T18:50:56Z

Evidence of lifespan extension

← Older revision		Revision as of 18:50, 15 April 2023
Line 31:		Line 31:

	=== Non-mammals ===		=== Non-mammals ===
	Fisetin has been found to extend lifespan by 55% in S. ''cerevisiae''<ref>Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., ... & Sinclair, D. A. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. ''Nature'', ''425''(6954), 191-196.</ref> and 23% in D. ''melanogaster.''<ref>Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004). Sirtuin activators mimic caloric restriction and delay ageing in metazoans. ''Nature'', ''430''(7000), 686-689.</ref>		Fisetin has been found to extend lifespan by 55% in S. ''cerevisiae''<ref>Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., ... & Sinclair, D. A. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. ''Nature'', ''425''(6954), 191-196.</ref> and 23% in D. ''melanogaster.''<ref>Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004). Sirtuin activators mimic caloric restriction and delay ageing in metazoans. ''Nature'', ''430''(7000), 686-689.</ref>

			== CMS121 ==
			CMS121 is a small molecule and derivative of the flavonoid fisetin, that is '''400 times more potent, than fisetin''' in the ischemia assay and is able to rescue cells from oxytotic/ferroptotic cell death.<ref>Chiruta, C., Schubert, D., Dargusch, R., & Maher, P. (2012). Chemical modification of the multitarget neuroprotective compound fisetin. Journal of Medicinal Chemistry, 55(1), 378-389. PMID: 22192055 PMCID: PMC3291199 DOI: 10.1021/jm2012563</ref><ref>Prior, M., Chiruta, C., Currais, A., Goldberg, J., Ramsey, J., Dargusch, R., ... & Schubert, D. (2014). Back to the future with phenotypic screening. ACS Chemical Neuroscience, 5(7), 503-513. PMID: 24902068 PMCID: PMC4102969 DOI: 10.1021/cn500051h</ref>

			CMS121 is a direct fatty acid synthase (FASN) inhibitor which, by CMS121-mediated, dose-dependent decrease in fatty acid synthase activity, alleviates cognitive loss, modulates lipid metabolism and reduces inflammation and lipid peroxidation in the brains of transgenic model of Alzheimer's disease mice.<ref>Ates, G., Goldberg, J., Currais, A., & Maher, P. (2020). CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease. Redox Biology, 36, 101648. PMID: 32863221 PMC7394765 DOI: 10.1016/j.redox.2020.101648</ref>
			Long-term treatments with CMS121 restored a more youthful level of physiological markers and prevent age-associated disease in both brain and kidney.<ref>Kepchia, D., Currais, A., Dargusch, R., Finley, K., Schubert, D., & Maher, P. (2021). Geroprotective effects of Alzheimer’s disease drug candidates. Aging (Albany NY), 13(3), 3269. PMID: 33550278 PMCID: PMC7906177 DOI: 10.18632/aging.202631</ref><ref>Zahid, S., Dafre, A. L., Currais, A., Yu, J., Schubert, D., & Maher, P. (2023). The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice. International Journal of Molecular Sciences, 24(7), 6828. https://doi.org/10.3390/ijms24076828</ref>

	== Biological mechanism ==		== Biological mechanism ==

Andrea: updated context and ref

2023-02-01T17:23:35Z

updated context and ref

← Older revision		Revision as of 17:23, 1 February 2023
Line 1:		Line 1:
	[[File:Molecular structure of fisetin.png\|thumb\|216x216px\|Molecular structure of fisetin.]]		[[File:Molecular structure of fisetin.png\|thumb\|216x216px\|Molecular structure of fisetin.]]
	Fisetin is a potent, plant-based polyphenol compound that has been found to reduce [[Cellular senescence\|senescence]] markers (signs of cellular aging) in human and animal tissues.<ref name=":0">[https://pubmed.ncbi.nlm.nih.gov/30279143/ Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L., … Niedernhofer, L. J. (2018). Fisetin is a senotherapeutic that extends health and lifespan. ''EBioMedicine'', ''36'', 18–28. https://doi.org/10.1016/j.ebiom.2018.09.015]</ref> It can be extracted from most vegetables and fruits, such as strawberries (160 μg/g), apples (26.9 μg/g), persimmons (10.6 μg/g), lotus roots (5.8 μg/g), onions (4.8 μg/g), grapes (3.9 μg/g), kiwi (2.0 μg/g), peaches (0.6 μg/g), and cucumbers (0.1 μg/g).<ref>Kim, H. J., Kim, S. H., & Yun, J. M. (2012). Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms. ''Evidence-based complementary and alternative medicine : eCAM'', ''2012'', 639469. https://doi.org/10.1155/2012/639469.</ref><ref name=":2">Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(2), 151-162. http://doi.org/10.1089/ars.2012.4901</ref> Fisetin has many therapeutic benefits, including anti-inflammatory, cardioprotective, and neuroprotective properties. It is also an antiangiogenic, meaning it can reduce the growth of unwanted blood vessels.<ref>Mehta, P., Pawar, A., Mahadik, K., & Bothiraja C. (2018). Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. ''Biomedicine & Pharmacotherapy'', ''106'', 1282-1291. https://doi.org/10.1016/j.biopha.2018.07.079</ref>		Fisetin is a potent, plant-based polyphenol compound that has been found to reduce [[Cellular senescence\|senescence]] markers (signs of cellular aging) in human and animal tissues.<ref name=":0">[https://pubmed.ncbi.nlm.nih.gov/30279143/ Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L., … Niedernhofer, L. J. (2018). Fisetin is a senotherapeutic that extends health and lifespan. ''EBioMedicine'', ''36'', 18–28. https://doi.org/10.1016/j.ebiom.2018.09.015]</ref> It can be extracted from most vegetables and fruits, such as strawberries (160 μg/g), apples (26.9 μg/g), persimmons (10.6 μg/g), lotus roots (5.8 μg/g), onions (4.8 μg/g), grapes (3.9 μg/g), kiwi (2.0 μg/g), peaches (0.6 μg/g), and cucumbers (0.1 μg/g).<ref>Kim, H. J., Kim, S. H., & Yun, J. M. (2012). Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms. ''Evidence-based complementary and alternative medicine : eCAM'', ''2012'', 639469. https://doi.org/10.1155/2012/639469.</ref><ref name=":2">Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(2), 151-162. http://doi.org/10.1089/ars.2012.4901</ref> Fisetin has many therapeutic benefits, including anti-inflammatory, cardioprotective, and neuroprotective properties. It is also an antiangiogenic, meaning it can reduce the growth of unwanted blood vessels.<ref>Mehta, P., Pawar, A., Mahadik, K., & Bothiraja C. (2018). Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. ''Biomedicine & Pharmacotherapy'', ''106'', 1282-1291. https://doi.org/10.1016/j.biopha.2018.07.079</ref>

			It is important to note that the consequences of eliminating senescent cells ''in vivo'' remains unknown, with some studies suggesting that it might be detrimental.<ref>Born, E. ''et al.'' (2022) “Eliminating senescent cells can promote pulmonary hypertension development and progression,” ''Circulation'' [Preprint]. Available at: <nowiki>https://doi.org/10.1161/circulationaha.122.058794</nowiki>. </ref>

	== Evidence of lifespan extension ==		== Evidence of lifespan extension ==
Line 23:		Line 25:
	Yousefzadeh et al. (2018) argue that this result demonstrates both that fisetin can destroy senescent cells and that fisetin does not have to be continuously present to successfully suppress senescence.<ref name=":0" />		Yousefzadeh et al. (2018) argue that this result demonstrates both that fisetin can destroy senescent cells and that fisetin does not have to be continuously present to successfully suppress senescence.<ref name=":0" />
	=== Humans ===		=== Humans ===
	~~In preliminary~~ studies in ~~humans~~, ~~some data has~~ suggested that fisetin can be an effective supplement to clear senescent cells~~, and therefore affect aging~~.		Preliminary studies in human adipose explant tissues, suggested that fisetin can be an effective supplement to clear senescent cells.<ref name=":0" />

	=== Mammals ===		=== Mammals ===

Andrea: category change, hyperlinks

2022-12-27T12:27:50Z

category change, hyperlinks

← Older revision		Revision as of 12:27, 27 December 2022
Line 1:		Line 1:
	[[File:Molecular structure of fisetin.png\|thumb\|216x216px\|Molecular structure of fisetin.]]		[[File:Molecular structure of fisetin.png\|thumb\|216x216px\|Molecular structure of fisetin.]]
	Fisetin is a potent, plant-based polyphenol compound that has been found to reduce senescence markers (signs of cellular aging) in human and animal tissues.<ref name=":0">[https://pubmed.ncbi.nlm.nih.gov/30279143/ Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L., … Niedernhofer, L. J. (2018). Fisetin is a senotherapeutic that extends health and lifespan. ''EBioMedicine'', ''36'', 18–28. https://doi.org/10.1016/j.ebiom.2018.09.015]</ref> It can be extracted from most vegetables and fruits, such as strawberries (160 μg/g), apples (26.9 μg/g), persimmons (10.6 μg/g), lotus roots (5.8 μg/g), onions (4.8 μg/g), grapes (3.9 μg/g), kiwi (2.0 μg/g), peaches (0.6 μg/g), and cucumbers (0.1 μg/g).<ref>Kim, H. J., Kim, S. H., & Yun, J. M. (2012). Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms. ''Evidence-based complementary and alternative medicine : eCAM'', ''2012'', 639469. https://doi.org/10.1155/2012/639469.</ref><ref name=":2">Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(2), 151-162. http://doi.org/10.1089/ars.2012.4901</ref> Fisetin has many therapeutic benefits, including anti-inflammatory, cardioprotective, and neuroprotective properties. It is also an antiangiogenic, meaning it can reduce the growth of unwanted blood vessels.<ref>Mehta, P., Pawar, A., Mahadik, K., & Bothiraja C. (2018). Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. ''Biomedicine & Pharmacotherapy'', ''106'', 1282-1291. https://doi.org/10.1016/j.biopha.2018.07.079</ref>		Fisetin is a potent, plant-based polyphenol compound that has been found to reduce [[Cellular senescence\|senescence]] markers (signs of cellular aging) in human and animal tissues.<ref name=":0">[https://pubmed.ncbi.nlm.nih.gov/30279143/ Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L., … Niedernhofer, L. J. (2018). Fisetin is a senotherapeutic that extends health and lifespan. ''EBioMedicine'', ''36'', 18–28. https://doi.org/10.1016/j.ebiom.2018.09.015]</ref> It can be extracted from most vegetables and fruits, such as strawberries (160 μg/g), apples (26.9 μg/g), persimmons (10.6 μg/g), lotus roots (5.8 μg/g), onions (4.8 μg/g), grapes (3.9 μg/g), kiwi (2.0 μg/g), peaches (0.6 μg/g), and cucumbers (0.1 μg/g).<ref>Kim, H. J., Kim, S. H., & Yun, J. M. (2012). Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms. ''Evidence-based complementary and alternative medicine : eCAM'', ''2012'', 639469. https://doi.org/10.1155/2012/639469.</ref><ref name=":2">Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(2), 151-162. http://doi.org/10.1089/ars.2012.4901</ref> Fisetin has many therapeutic benefits, including anti-inflammatory, cardioprotective, and neuroprotective properties. It is also an antiangiogenic, meaning it can reduce the growth of unwanted blood vessels.<ref>Mehta, P., Pawar, A., Mahadik, K., & Bothiraja C. (2018). Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. ''Biomedicine & Pharmacotherapy'', ''106'', 1282-1291. https://doi.org/10.1016/j.biopha.2018.07.079</ref>

	== Evidence of lifespan extension ==		== Evidence of lifespan extension ==
	The primary advantage of fisetin treatment is that it targets senescent cells (SCs).		The primary advantage of fisetin treatment is that it targets [[Cellular senescence\|senescent cells]] (SCs).

	SCs are cells that have accumulated DNA damage or other stressors, which leads to changes in two types of cellular proteins: chromatin, the protein that chromosomes, including RNA and DNA, are made of; and secretome, a general name for the expression profile of proteins secreted by human cells. These changes lead to apoptosis (programmed cell death) which prevents the cell from replicating.<ref name=":0" /> This mechanism is designed to prevent the cell from becoming a cancer cell.		SCs are cells that have accumulated DNA damage or other stressors, which leads to changes in two types of cellular proteins: chromatin, the protein that chromosomes, including RNA and DNA, are made of; and secretome, a general name for the expression profile of proteins secreted by human cells. These changes lead to apoptosis (programmed cell death) which prevents the cell from replicating.<ref name=":0" /> This mechanism is designed to prevent the cell from becoming a cancer cell.
Line 43:		Line 43:
	Interestingly, fisetin can also "blunt" IRI-induced apoptosis in damaged myocardial tissues.		Interestingly, fisetin can also "blunt" IRI-induced apoptosis in damaged myocardial tissues.

	=== Cancer ===		=== [[Aging and cancer\|Cancer]] ===
	Fisetin can help inhibit the growth of and expedite the death of cancerous colon cells. It does this in two ways:		Fisetin can help inhibit the growth of and expedite the death of cancerous colon cells. It does this in two ways:

Line 55:		Line 55:

	<references />		<references />
	[[Category:~~Longevity~~]]		[[Category:Main list]]
	[[Category:~~Medication]]~~		[[Category:Drugs]]
	~~[[Category:Supplement~~]]

Andrea: /* Evidence of lifespan extension */

2022-11-06T16:34:42Z

Evidence of lifespan extension

@@ Line 1: / Line 1: @@
-{{Draft-article }}[[File:Molecular structure of fisetin.png|thumb|216x216px|Molecular structure of fisetin.]]
+[[File:Molecular structure of fisetin.png|thumb|216x216px|Molecular structure of fisetin.]]
 Fisetin is a potent, plant-based polyphenol compound that has been found to reduce senescence markers (signs of cellular aging) in human and animal tissues.<ref name=":0">[https://pubmed.ncbi.nlm.nih.gov/30279143/ Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L., … Niedernhofer, L. J. (2018). Fisetin is a senotherapeutic that extends health and lifespan. ''EBioMedicine'', ''36'', 18–28. https://doi.org/10.1016/j.ebiom.2018.09.015]</ref> It can be extracted from most vegetables and fruits, such as strawberries (160 μg/g), apples (26.9 μg/g), persimmons (10.6 μg/g), lotus roots (5.8 μg/g), onions (4.8 μg/g), grapes (3.9 μg/g), kiwi (2.0 μg/g), peaches (0.6 μg/g), and cucumbers (0.1 μg/g).<ref>Kim, H. J., Kim, S. H., & Yun, J. M. (2012). Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms. ''Evidence-based complementary and alternative medicine : eCAM'', ''2012'', 639469. https://doi.org/10.1155/2012/639469.</ref><ref name=":2">Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(2), 151-162. http://doi.org/10.1089/ars.2012.4901</ref> Fisetin has many therapeutic benefits, including anti-inflammatory, cardioprotective, and neuroprotective properties. It is also an antiangiogenic, meaning it can reduce the growth of unwanted blood vessels.<ref>Mehta, P., Pawar, A., Mahadik, K., & Bothiraja C. (2018). Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. ''Biomedicine & Pharmacotherapy'', ''106'', 1282-1291. https://doi.org/10.1016/j.biopha.2018.07.079</ref>
@@ Line 53: / Line 53: @@
 Since MMP-1 promotes ECM remodelling and fisetin inhibits MMP-1 activity, fisetin thus helps to slow the progression of cancer.
 <references />

202.125.26.142 at 00:55, 22 September 2021

2021-09-22T00:55:30Z

@@ Line 52: / Line 52: @@
 ECM remodelling describes the changes that occur in cells when they undergo neoplastic transformation, i.e. when they grow more rapidly than they should, or do not die when they should. More broadly, this can manifest as tumor growth and metastasis of cancerous cells.<ref name=":2" />
-Since MMP-1 promotes ECM remodelling and fisetin inhibits MMP-1 activity, fisetin thus helps to slow the progression of cancer.<references />
+Since MMP-1 promotes ECM remodelling and fisetin inhibits MMP-1 activity, fisetin thus helps to slow the progression of cancer.
 [[Category:Longevity]]
 [[Category:Medication]]
 [[Category:Supplement]]

202.125.26.142 at 00:52, 22 September 2021

2021-09-22T00:52:51Z

← Older revision		Revision as of 00:52, 22 September 2021
Line 1:		Line 1:
	[[File:Molecular structure of fisetin.png\|thumb\|216x216px\|Molecular structure of fisetin.]]		{{Draft-article }}[[File:Molecular structure of fisetin.png\|thumb\|216x216px\|Molecular structure of fisetin.]]
	Fisetin is a potent, plant-based polyphenol compound that has been found to reduce senescence markers (signs of cellular aging) in human and animal tissues.<ref name=":0">[https://pubmed.ncbi.nlm.nih.gov/30279143/ Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L., … Niedernhofer, L. J. (2018). Fisetin is a senotherapeutic that extends health and lifespan. ''EBioMedicine'', ''36'', 18–28. https://doi.org/10.1016/j.ebiom.2018.09.015]</ref> It can be extracted from most vegetables and fruits, such as strawberries (160 μg/g), apples (26.9 μg/g), persimmons (10.6 μg/g), lotus roots (5.8 μg/g), onions (4.8 μg/g), grapes (3.9 μg/g), kiwi (2.0 μg/g), peaches (0.6 μg/g), and cucumbers (0.1 μg/g).<ref>Kim, H. J., Kim, S. H., & Yun, J. M. (2012). Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms. ''Evidence-based complementary and alternative medicine : eCAM'', ''2012'', 639469. https://doi.org/10.1155/2012/639469.</ref><ref name=":2">Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(2), 151-162. http://doi.org/10.1089/ars.2012.4901</ref> Fisetin has many therapeutic benefits, including anti-inflammatory, cardioprotective, and neuroprotective properties. It is also an antiangiogenic, meaning it can reduce the growth of unwanted blood vessels.<ref>Mehta, P., Pawar, A., Mahadik, K., & Bothiraja C. (2018). Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. ''Biomedicine & Pharmacotherapy'', ''106'', 1282-1291. https://doi.org/10.1016/j.biopha.2018.07.079</ref>		Fisetin is a potent, plant-based polyphenol compound that has been found to reduce senescence markers (signs of cellular aging) in human and animal tissues.<ref name=":0">[https://pubmed.ncbi.nlm.nih.gov/30279143/ Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L., … Niedernhofer, L. J. (2018). Fisetin is a senotherapeutic that extends health and lifespan. ''EBioMedicine'', ''36'', 18–28. https://doi.org/10.1016/j.ebiom.2018.09.015]</ref> It can be extracted from most vegetables and fruits, such as strawberries (160 μg/g), apples (26.9 μg/g), persimmons (10.6 μg/g), lotus roots (5.8 μg/g), onions (4.8 μg/g), grapes (3.9 μg/g), kiwi (2.0 μg/g), peaches (0.6 μg/g), and cucumbers (0.1 μg/g).<ref>Kim, H. J., Kim, S. H., & Yun, J. M. (2012). Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms. ''Evidence-based complementary and alternative medicine : eCAM'', ''2012'', 639469. https://doi.org/10.1155/2012/639469.</ref><ref name=":2">Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(2), 151-162. http://doi.org/10.1089/ars.2012.4901</ref> Fisetin has many therapeutic benefits, including anti-inflammatory, cardioprotective, and neuroprotective properties. It is also an antiangiogenic, meaning it can reduce the growth of unwanted blood vessels.<ref>Mehta, P., Pawar, A., Mahadik, K., & Bothiraja C. (2018). Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. ''Biomedicine & Pharmacotherapy'', ''106'', 1282-1291. https://doi.org/10.1016/j.biopha.2018.07.079</ref>

MessyMassey: /* Cancer */

2021-08-06T13:21:24Z

Cancer

← Older revision		Revision as of 13:21, 6 August 2021
Line 47:		Line 47:

	# Inhibiting anti-apoptotic B-cell lymphoma 2 (BCL-2) cells. B-cell lymphoma 2 proteins prevent cell death (apoptosis) in both healthy and cancerous cells. By targeting BCL-2, fisetin can help ensure that malignant cells undergo normal programmed cell death.		# Inhibiting anti-apoptotic B-cell lymphoma 2 (BCL-2) cells. B-cell lymphoma 2 proteins prevent cell death (apoptosis) in both healthy and cancerous cells. By targeting BCL-2, fisetin can help ensure that malignant cells undergo normal programmed cell death.
	# Induce pro-apoptotic Caspase-9 and Caspase-3 gene expression in cancerous colon cells. Caspase-9 and Caspase-3 are proteins expressed by the CASP9 and CASP3 genes respectively; both proteins induce apoptosis (cell death) by destroying critical cell infrastructures.<ref>Fan, Q., Wang, X., Chinnathambi, A., Alharbi, S. A., & Wang, Q. (2020). Fisetin suppresses 1, 2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats via enhancing the apoptotic signaling pathway. ''Journal of King Saud University-Science'', ''32''(3), 1959-1964.</ref>		# Induce pro-apoptotic Caspase-9 and Caspase-3 gene expression in cancerous colon cells. Caspase-9 and Caspase-3 are proteins expressed by the CASP9 and CASP3 genes respectively; both proteins induce apoptosis (cell death) by destroying critical cell infrastructures.<ref>Fan, Q., Wang, X., Chinnathambi, A., Alharbi, S. A., & Wang, Q. (2020). Fisetin suppresses 1, 2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats via enhancing the apoptotic signaling pathway. ''Journal of King Saud University-Science'', ''32''(3), 1959-1964.</ref>

	Fisetin has also been found to be an effective inhibitor of matrix metalloproteinase (MMP)-1 activity. MMP-1 aids in extracellular matrix (ECM) remodelling and degradation which can occur during neoplastic transformation like uncontrolled cell growth or failed apoptosis. More broadly, this can manifest as tumor growth and metastasis of cancerous cells.<ref name=":2" /> Since MMP-1 promotes ECM remodelling and fisetin inhibits MMP-1 activity, fisetin thus helps to slow the progression of cancer.		Fisetin has also been found to be an effective inhibitor of matrix metalloproteinase (MMP)-1 activity. MMP-1 aids in extracellular matrix (ECM) remodelling and degradation which can occur during neoplastic transformation like uncontrolled cell growth or failed apoptosis. More broadly, this can manifest as tumor growth and metastasis of cancerous cells.<ref name=":2" /> Since MMP-1 promotes ECM remodelling and fisetin inhibits MMP-1 activity, fisetin thus helps to slow the progression of cancer.

MessyMassey: /* Evidence of lifespan extension */

2021-08-06T13:20:29Z

Evidence of lifespan extension

← Older revision		Revision as of 13:20, 6 August 2021
Line 1:		Line 1:
	[[File:Molecular structure of fisetin.png\|thumb\|216x216px\|Molecular structure of fisetin.]]		[[File:Molecular structure of fisetin.png\|thumb\|216x216px\|Molecular structure of fisetin.]]
	Fisetin is a potent, plant-based polyphenol compound that has been found to reduce senescence markers (signs of cellular aging) in human and animal tissues.<ref name=":0">[https://pubmed.ncbi.nlm.nih.gov/30279143/ Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L., … Niedernhofer, L. J. (2018). Fisetin is a senotherapeutic that extends health and lifespan. ''EBioMedicine'', ''36'', 18–28. https://doi.org/10.1016/j.ebiom.2018.09.015]</ref> It can be extracted from most vegetables and fruits, such as strawberries (160 μg/g), apples (26.9 μg/g), persimmons (10.6 μg/g), lotus roots (5.8 μg/g), onions (4.8 μg/g), grapes (3.9 μg/g), kiwi (2.0 μg/g), peaches (0.6 μg/g), and cucumbers (0.1 μg/g).<ref>Kim, H. J., Kim, S. H., & Yun, J. M. (2012). Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms. ''Evidence-based complementary and alternative medicine : eCAM'', ''2012'', 639469. https://doi.org/10.1155/2012/639469.</ref><ref name=":2" /> Fisetin has many therapeutic benefits, including anti-inflammatory, cardioprotective, and neuroprotective properties. It is also an antiangiogenic, meaning it can reduce the growth of unwanted blood vessels.<ref>Mehta, P., Pawar, A., Mahadik, K., & Bothiraja C. (2018). Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. ''Biomedicine & Pharmacotherapy'', ''106'', 1282-1291. https://doi.org/10.1016/j.biopha.2018.07.079</ref>		Fisetin is a potent, plant-based polyphenol compound that has been found to reduce senescence markers (signs of cellular aging) in human and animal tissues.<ref name=":0">[https://pubmed.ncbi.nlm.nih.gov/30279143/ Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L., … Niedernhofer, L. J. (2018). Fisetin is a senotherapeutic that extends health and lifespan. ''EBioMedicine'', ''36'', 18–28. https://doi.org/10.1016/j.ebiom.2018.09.015]</ref> It can be extracted from most vegetables and fruits, such as strawberries (160 μg/g), apples (26.9 μg/g), persimmons (10.6 μg/g), lotus roots (5.8 μg/g), onions (4.8 μg/g), grapes (3.9 μg/g), kiwi (2.0 μg/g), peaches (0.6 μg/g), and cucumbers (0.1 μg/g).<ref>Kim, H. J., Kim, S. H., & Yun, J. M. (2012). Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms. ''Evidence-based complementary and alternative medicine : eCAM'', ''2012'', 639469. https://doi.org/10.1155/2012/639469.</ref><ref name=":2">Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(2), 151-162. http://doi.org/10.1089/ars.2012.4901</ref> Fisetin has many therapeutic benefits, including anti-inflammatory, cardioprotective, and neuroprotective properties. It is also an antiangiogenic, meaning it can reduce the growth of unwanted blood vessels.<ref>Mehta, P., Pawar, A., Mahadik, K., & Bothiraja C. (2018). Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. ''Biomedicine & Pharmacotherapy'', ''106'', 1282-1291. https://doi.org/10.1016/j.biopha.2018.07.079</ref>

	== Evidence of lifespan extension ==		== Evidence of lifespan extension ==
Line 44:		Line 44:

	=== Cancer ===		=== Cancer ===
	Fisetin ~~has been found to~~ inhibit anti-apoptotic ~~Bcl~~-2 cells and ~~induce~~ pro-apoptotic Caspase-9 and Caspase-3 expression in cancerous colon cells.<ref>Fan, Q., Wang, X., Chinnathambi, A., Alharbi, S. A., & Wang, Q. (2020). Fisetin suppresses 1, 2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats via enhancing the apoptotic signaling pathway. ''Journal of King Saud University-Science'', ''32''(3), 1959-1964.</ref> ~~In other words, fisetin both inhibits the growth of and promotes the death of cancerous colon cells.~~ Fisetin has also been found to be an effective inhibitor of matrix metalloproteinase (MMP)-1 activity~~, an important enzyme~~ in remodelling and degradation of ~~the extracellular matrix which plays a major role in cancer progression~~. <ref name=":2">~~Khan~~, N., ~~Syed, D~~. N., ~~Ahmad, N~~., ~~& Mukhtar, H~~. ~~(2013). Fisetin~~: ~~a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(~~2), ~~151-162~~. ~~http://doi.org/10.1089/ars.2012.4901</ref>~~ <references />		Fisetin can help inhibit the growth of and expedite the death of cancerous colon cells. It does this in two ways:

			# Inhibiting anti-apoptotic B-cell lymphoma 2 (BCL-2) cells. B-cell lymphoma 2 proteins prevent cell death (apoptosis) in both healthy and cancerous cells. By targeting BCL-2, fisetin can help ensure that malignant cells undergo normal programmed cell death.
			# Induce pro-apoptotic Caspase-9 and Caspase-3 gene expression in cancerous colon cells. Caspase-9 and Caspase-3 are proteins expressed by the CASP9 and CASP3 genes respectively; both proteins induce apoptosis (cell death) by destroying critical cell infrastructures.<ref>Fan, Q., Wang, X., Chinnathambi, A., Alharbi, S. A., & Wang, Q. (2020). Fisetin suppresses 1, 2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats via enhancing the apoptotic signaling pathway. ''Journal of King Saud University-Science'', ''32''(3), 1959-1964.</ref>

			Fisetin has also been found to be an effective inhibitor of matrix metalloproteinase (MMP)-1 activity. MMP-1 aids in extracellular matrix (ECM) remodelling and degradation which can occur during neoplastic transformation like uncontrolled cell growth or failed apoptosis. More broadly, this can manifest as tumor growth and metastasis of cancerous cells.<ref name=":2" /> Since MMP-1 promotes ECM remodelling and fisetin inhibits MMP-1 activity, fisetin thus helps to slow the progression of cancer.

			ECM remodelling describes the changes that occur in cells when they undergo neoplastic transformation, i.e. when they grow more rapidly than they should, or do not die when they should. More broadly, this can manifest as tumor growth and metastasis of cancerous cells.<ref name=":2" />

			Since MMP-1 promotes ECM remodelling and fisetin inhibits MMP-1 activity, fisetin thus helps to slow the progression of cancer.<references />
	[[Category:Longevity]]		[[Category:Longevity]]
	[[Category:Medication]]		[[Category:Medication]]
	[[Category:Supplement]]		[[Category:Supplement]]

MessyMassey: /* Evidence of lifespan extension */

2021-07-05T18:03:51Z

Evidence of lifespan extension

← Older revision		Revision as of 18:03, 5 July 2021
Line 46:		Line 46:
	Fisetin has been found to inhibit anti-apoptotic Bcl-2 cells and induce pro-apoptotic Caspase-9 and Caspase-3 expression in cancerous colon cells.<ref>Fan, Q., Wang, X., Chinnathambi, A., Alharbi, S. A., & Wang, Q. (2020). Fisetin suppresses 1, 2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats via enhancing the apoptotic signaling pathway. ''Journal of King Saud University-Science'', ''32''(3), 1959-1964.</ref> In other words, fisetin both inhibits the growth of and promotes the death of cancerous colon cells. Fisetin has also been found to be an effective inhibitor of matrix metalloproteinase (MMP)-1 activity, an important enzyme in remodelling and degradation of the extracellular matrix which plays a major role in cancer progression. <ref name=":2">Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(2), 151-162. http://doi.org/10.1089/ars.2012.4901</ref> <references />		Fisetin has been found to inhibit anti-apoptotic Bcl-2 cells and induce pro-apoptotic Caspase-9 and Caspase-3 expression in cancerous colon cells.<ref>Fan, Q., Wang, X., Chinnathambi, A., Alharbi, S. A., & Wang, Q. (2020). Fisetin suppresses 1, 2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats via enhancing the apoptotic signaling pathway. ''Journal of King Saud University-Science'', ''32''(3), 1959-1964.</ref> In other words, fisetin both inhibits the growth of and promotes the death of cancerous colon cells. Fisetin has also been found to be an effective inhibitor of matrix metalloproteinase (MMP)-1 activity, an important enzyme in remodelling and degradation of the extracellular matrix which plays a major role in cancer progression. <ref name=":2">Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(2), 151-162. http://doi.org/10.1089/ars.2012.4901</ref> <references />
	[[Category:Longevity]]		[[Category:Longevity]]
			[[Category:Medication]]
			[[Category:Supplement]]

Bogdan at 15:11, 5 July 2021

2021-07-05T15:11:59Z

← Older revision		Revision as of 15:11, 5 July 2021
Line 45:		Line 45:
	=== Cancer ===		=== Cancer ===
	Fisetin has been found to inhibit anti-apoptotic Bcl-2 cells and induce pro-apoptotic Caspase-9 and Caspase-3 expression in cancerous colon cells.<ref>Fan, Q., Wang, X., Chinnathambi, A., Alharbi, S. A., & Wang, Q. (2020). Fisetin suppresses 1, 2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats via enhancing the apoptotic signaling pathway. ''Journal of King Saud University-Science'', ''32''(3), 1959-1964.</ref> In other words, fisetin both inhibits the growth of and promotes the death of cancerous colon cells. Fisetin has also been found to be an effective inhibitor of matrix metalloproteinase (MMP)-1 activity, an important enzyme in remodelling and degradation of the extracellular matrix which plays a major role in cancer progression. <ref name=":2">Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(2), 151-162. http://doi.org/10.1089/ars.2012.4901</ref> <references />		Fisetin has been found to inhibit anti-apoptotic Bcl-2 cells and induce pro-apoptotic Caspase-9 and Caspase-3 expression in cancerous colon cells.<ref>Fan, Q., Wang, X., Chinnathambi, A., Alharbi, S. A., & Wang, Q. (2020). Fisetin suppresses 1, 2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats via enhancing the apoptotic signaling pathway. ''Journal of King Saud University-Science'', ''32''(3), 1959-1964.</ref> In other words, fisetin both inhibits the growth of and promotes the death of cancerous colon cells. Fisetin has also been found to be an effective inhibitor of matrix metalloproteinase (MMP)-1 activity, an important enzyme in remodelling and degradation of the extracellular matrix which plays a major role in cancer progression. <ref name=":2">Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant fro health promotion. ''Antioxidants & Redox signaling'', ''19''(2), 151-162. http://doi.org/10.1089/ars.2012.4901</ref> <references />
			[[Category:Longevity]]