Hormesis - Revision history

Andrea at 18:33, 26 January 2023

2023-01-26T18:33:14Z

← Older revision		Revision as of 18:33, 26 January 2023
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	Hormesis (from the Greek word "normao", meaning "to excite") is a biological phenomenon in which a beneficial effect (such as increased lifespan, stress tolerance, or growth) results from exposure to low doses of a potentially harmful substance or condition (such as heat, radiation, or toxins).<ref>Mattson MP. Hormesis defined. Ageing Res Rev. 2008 Jan;7(1):1-7. doi: 10.1016/j.arr.2007.08.007. Epub 2007 Dec 5. PMID: 18162444; PMCID: PMC2248601.</ref> Hormesis is characterized by a dose-response relationship, in which a low dose of a stressor produces a positive effect, while a high dose produces a negative effect. Hormesis is studied in different areas of biology, such as in the response of cells to environmental stressors or toxins.		Hormesis (from the Greek word "normao", meaning "to excite") is a biological phenomenon in which a beneficial effect (such as increased lifespan, stress tolerance, or growth) results from exposure to low doses of a potentially harmful substance or condition (such as heat, radiation, or toxins).<ref>Mattson MP. Hormesis defined. Ageing Res Rev. 2008 Jan;7(1):1-7. doi: 10.1016/j.arr.2007.08.007. Epub 2007 Dec 5. PMID: 18162444; PMCID: PMC2248601.</ref> Hormesis is characterized by a dose-response relationship, in which a low dose of a stressor produces a positive effect, while a high dose produces a negative effect. Hormesis is studied in different areas of biology, such as in the response of cells to environmental stressors or toxins.

	Some researchers have proposed that hormesis may play a role in the aging process. Certain types of cellular stress, such as [[Calorie restriction\|caloric restriction]] and exposure to mild toxins, have been shown to extend lifespan in a variety of animal models.<ref>Kouda, K. and Iki, M. (2010) “Beneficial effects of mild stress (hormetic effects): Dietary restriction and health,” ''Journal of PHYSIOLOGICAL ANTHROPOLOGY'', 29(4), pp. 127–132. Available at: <nowiki>https://doi.org/10.2114/jpa2.29.127</nowiki>. </ref><ref>Masoro EJ. Role of hormesis in life extension by caloric restriction. Dose Response. 2006 Aug 19;5(2):163-73. doi: 10.2203/dose-response.06-005.Masoro. PMID: 18648602; PMCID: PMC2477693.</ref> Mild [[Calorie restriction\|dietary restriction]] without malnutrition has demonstrated able to prevent the onset or to decrease the severity of several age-related diseases, such as [[Aging and cancer\|cancer]], [[Aging and neurodegeneration\|neurodegeneration]] or cardiovascular diseases.<ref>Flanagan, E. W., Most, J., Mey, J. T., & Redman, L. M. (2020). Calorie Restriction and Aging in Humans. ''Annual Review of Nutrition'', ''40'', 105-133.</ref> [[Heat-shock response\|Heat]]- or cold-shock responses are also considered to be hormesis mechanisms.<ref>Mane NR, Gajare KA, Deshmukh AA. Mild heat stress induces hormetic effects in protecting the primary culture of mouse prefrontal cerebrocortical neurons from neuropathological alterations. IBRO Rep. 2018 Nov 14;5:110-115. doi: 10.1016/j.ibror.2018.11.002. PMID: 30519667; PMCID: PMC6260229.</ref><ref>Rattan SI. Hormetic modulation of aging and longevity by mild heat stress. Dose Response. 2006 May 22;3(4):533-46. doi: 10.2203/dose-response.003.04.008. PMID: 18648625; PMCID: PMC2477195.</ref>		Some researchers have proposed that hormesis may play a role in the aging process. Certain types of cellular stress, such as [[Calorie restriction\|caloric restriction]] and exposure to mild toxins, have been shown to extend lifespan in a variety of animal models.<ref>Kouda, K. and Iki, M. (2010) “Beneficial effects of mild stress (hormetic effects): Dietary restriction and health,” ''Journal of PHYSIOLOGICAL ANTHROPOLOGY'', 29(4), pp. 127–132. Available at: <nowiki>https://doi.org/10.2114/jpa2.29.127</nowiki>. </ref><ref>Masoro EJ. Role of hormesis in life extension by caloric restriction. Dose Response. 2006 Aug 19;5(2):163-73. doi: 10.2203/dose-response.06-005.Masoro. PMID: 18648602; PMCID: PMC2477693.</ref> Mild [[Calorie restriction\|dietary restriction]] without malnutrition has demonstrated able to prevent the onset or to decrease the severity of several age-related diseases, such as [[Aging and cancer\|cancer]], [[Aging and neurodegeneration\|neurodegeneration]] or cardiovascular diseases.<ref>Flanagan, E. W., Most, J., Mey, J. T., & Redman, L. M. (2020). Calorie Restriction and Aging in Humans. ''Annual Review of Nutrition'', ''40'', 105-133.</ref> [[Heat-shock response\|Heat-shock]] or cold-shock responses are also considered to be hormesis mechanisms.<ref>Mane NR, Gajare KA, Deshmukh AA. Mild heat stress induces hormetic effects in protecting the primary culture of mouse prefrontal cerebrocortical neurons from neuropathological alterations. IBRO Rep. 2018 Nov 14;5:110-115. doi: 10.1016/j.ibror.2018.11.002. PMID: 30519667; PMCID: PMC6260229.</ref><ref>Rattan SI. Hormetic modulation of aging and longevity by mild heat stress. Dose Response. 2006 May 22;3(4):533-46. doi: 10.2203/dose-response.003.04.008. PMID: 18648625; PMCID: PMC2477195.</ref>

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← Older revision		Revision as of 18:32, 26 January 2023
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	Hormesis (from the Greek word "normao", meaning "to excite") is a biological phenomenon in which a beneficial effect (such as increased lifespan, stress tolerance, or growth) results from exposure to low doses of a potentially harmful substance or condition (such as heat, radiation, or toxins).<ref>Mattson MP. Hormesis defined. Ageing Res Rev. 2008 Jan;7(1):1-7. doi: 10.1016/j.arr.2007.08.007. Epub 2007 Dec 5. PMID: 18162444; PMCID: PMC2248601.</ref> Hormesis is characterized by a dose-response relationship, in which a low dose of a stressor produces a positive effect, while a high dose produces a negative effect. Hormesis is studied in different areas of biology, such as in the response of cells to environmental stressors or toxins.		Hormesis (from the Greek word "normao", meaning "to excite") is a biological phenomenon in which a beneficial effect (such as increased lifespan, stress tolerance, or growth) results from exposure to low doses of a potentially harmful substance or condition (such as heat, radiation, or toxins).<ref>Mattson MP. Hormesis defined. Ageing Res Rev. 2008 Jan;7(1):1-7. doi: 10.1016/j.arr.2007.08.007. Epub 2007 Dec 5. PMID: 18162444; PMCID: PMC2248601.</ref> Hormesis is characterized by a dose-response relationship, in which a low dose of a stressor produces a positive effect, while a high dose produces a negative effect. Hormesis is studied in different areas of biology, such as in the response of cells to environmental stressors or toxins.

	Some researchers have proposed that hormesis may play a role in the aging process. Certain types of cellular stress, such as [[Calorie restriction\|caloric restriction]] and exposure to mild toxins, have been shown to extend lifespan in a variety of animal models.<ref>Kouda, K. and Iki, M. (2010) “Beneficial effects of mild stress (hormetic effects): Dietary restriction and health,” ''Journal of PHYSIOLOGICAL ANTHROPOLOGY'', 29(4), pp. 127–132. Available at: <nowiki>https://doi.org/10.2114/jpa2.29.127</nowiki>. </ref><ref>Masoro EJ. Role of hormesis in life extension by caloric restriction. Dose Response. 2006 Aug 19;5(2):163-73. doi: 10.2203/dose-response.06-005.Masoro. PMID: 18648602; PMCID: PMC2477693.</ref> Mild [[Calorie restriction\|dietary restriction]] without malnutrition has demonstrated able to prevent the onset or to decrease the severity of several age-related diseases, such as [[Aging and cancer\|cancer]], [[Aging and neurodegeneration\|neurodegeneration]] or cardiovascular diseases.<ref>Flanagan, E. W., Most, J., Mey, J. T., & Redman, L. M. (2020). Calorie Restriction and Aging in Humans. ''Annual Review of Nutrition'', ''40'', 105-133.</ref> Heat- or cold-shock responses are also considered to be hormesis mechanisms.<ref>Mane NR, Gajare KA, Deshmukh AA. Mild heat stress induces hormetic effects in protecting the primary culture of mouse prefrontal cerebrocortical neurons from neuropathological alterations. IBRO Rep. 2018 Nov 14;5:110-115. doi: 10.1016/j.ibror.2018.11.002. PMID: 30519667; PMCID: PMC6260229.</ref><ref>Rattan SI. Hormetic modulation of aging and longevity by mild heat stress. Dose Response. 2006 May 22;3(4):533-46. doi: 10.2203/dose-response.003.04.008. PMID: 18648625; PMCID: PMC2477195.</ref>		Some researchers have proposed that hormesis may play a role in the aging process. Certain types of cellular stress, such as [[Calorie restriction\|caloric restriction]] and exposure to mild toxins, have been shown to extend lifespan in a variety of animal models.<ref>Kouda, K. and Iki, M. (2010) “Beneficial effects of mild stress (hormetic effects): Dietary restriction and health,” ''Journal of PHYSIOLOGICAL ANTHROPOLOGY'', 29(4), pp. 127–132. Available at: <nowiki>https://doi.org/10.2114/jpa2.29.127</nowiki>. </ref><ref>Masoro EJ. Role of hormesis in life extension by caloric restriction. Dose Response. 2006 Aug 19;5(2):163-73. doi: 10.2203/dose-response.06-005.Masoro. PMID: 18648602; PMCID: PMC2477693.</ref> Mild [[Calorie restriction\|dietary restriction]] without malnutrition has demonstrated able to prevent the onset or to decrease the severity of several age-related diseases, such as [[Aging and cancer\|cancer]], [[Aging and neurodegeneration\|neurodegeneration]] or cardiovascular diseases.<ref>Flanagan, E. W., Most, J., Mey, J. T., & Redman, L. M. (2020). Calorie Restriction and Aging in Humans. ''Annual Review of Nutrition'', ''40'', 105-133.</ref> [[Heat-shock response\|Heat]]- or cold-shock responses are also considered to be hormesis mechanisms.<ref>Mane NR, Gajare KA, Deshmukh AA. Mild heat stress induces hormetic effects in protecting the primary culture of mouse prefrontal cerebrocortical neurons from neuropathological alterations. IBRO Rep. 2018 Nov 14;5:110-115. doi: 10.1016/j.ibror.2018.11.002. PMID: 30519667; PMCID: PMC6260229.</ref><ref>Rattan SI. Hormetic modulation of aging and longevity by mild heat stress. Dose Response. 2006 May 22;3(4):533-46. doi: 10.2203/dose-response.003.04.008. PMID: 18648625; PMCID: PMC2477195.</ref>

	[[Category:Main list]]		[[Category:Main list]]
	[[Category:Longevity concepts]]		[[Category:Longevity concepts]]

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2023-01-26T18:32:06Z

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Hormesis (from the Greek word "normao", meaning "to excite") is a biological phenomenon in which a beneficial effect (such as increased lifespan, stress tolerance, or growth) results from exposure to low doses of a potentially harmful substance or condition (such as heat, radiation, or toxins).<ref>Mattson MP. Hormesis defined. Ageing Res Rev. 2008 Jan;7(1):1-7. doi: 10.1016/j.arr.2007.08.007. Epub 2007 Dec 5. PMID: 18162444; PMCID: PMC2248601.</ref> Hormesis is characterized by a dose-response relationship, in which a low dose of a stressor produces a positive effect, while a high dose produces a negative effect. Hormesis is studied in different areas of biology, such as in the response of cells to environmental stressors or toxins.

Some researchers have proposed that hormesis may play a role in the aging process. Certain types of cellular stress, such as [[Calorie restriction|caloric restriction]] and exposure to mild toxins, have been shown to extend lifespan in a variety of animal models.<ref>Kouda, K. and Iki, M. (2010) “Beneficial effects of mild stress (hormetic effects): Dietary restriction and health,” ''Journal of PHYSIOLOGICAL ANTHROPOLOGY'', 29(4), pp. 127–132. Available at: <nowiki>https://doi.org/10.2114/jpa2.29.127</nowiki>. </ref><ref>Masoro EJ. Role of hormesis in life extension by caloric restriction. Dose Response. 2006 Aug 19;5(2):163-73. doi: 10.2203/dose-response.06-005.Masoro. PMID: 18648602; PMCID: PMC2477693.</ref> Mild [[Calorie restriction|dietary restriction]] without malnutrition has demonstrated able to prevent the onset or to decrease the severity of several age-related diseases, such as [[Aging and cancer|cancer]], [[Aging and neurodegeneration|neurodegeneration]] or cardiovascular diseases.<ref>Flanagan, E. W., Most, J., Mey, J. T., & Redman, L. M. (2020). Calorie Restriction and Aging in Humans. ''Annual Review of Nutrition'', ''40'', 105-133.</ref> Heat- or cold-shock responses are also considered to be hormesis mechanisms.<ref>Mane NR, Gajare KA, Deshmukh AA. Mild heat stress induces hormetic effects in protecting the primary culture of mouse prefrontal cerebrocortical neurons from neuropathological alterations. IBRO Rep. 2018 Nov 14;5:110-115. doi: 10.1016/j.ibror.2018.11.002. PMID: 30519667; PMCID: PMC6260229.</ref><ref>Rattan SI. Hormetic modulation of aging and longevity by mild heat stress. Dose Response. 2006 May 22;3(4):533-46. doi: 10.2203/dose-response.003.04.008. PMID: 18648625; PMCID: PMC2477195.</ref>

[[Category:Main list]]
[[Category:Longevity concepts]]