Isofalcarintriol - Revision history

Dmitry Dzhagarov at 11:47, 5 January 2024

2024-01-05T11:47:21Z

← Older revision		Revision as of 11:47, 5 January 2024
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	\| Molecular Weight 278.39		\| Molecular Weight 278.39
	\|}		\|}
	'''Isofalcarintriol''' ((3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol) is a polyacetylene contained in the root of carrots (Daucus carota), which was revealed as potent promoter of longevity in the nematode ''C. elegans'' even at remarkably low doses.<ref name="carrots" >Thomas, C., Erni, R., Wu, J. Y., Fischer, F., Lamers, G., Grigolon, G., ... & Ristow, M. (2023). A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging. Nature Communications, 14(1), 8142. PMID:38065964 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10709416/ PMC:10709416] DOI\|10.1038/s41467-023-43672-7</ref>		'''Isofalcarintriol''' ((3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol) is a polyacetylene contained in the root of carrots (Daucus carota), which was revealed as potent promoter of longevity in the nematode ''C. elegans'' even at remarkably low doses.<ref name="carrots" >Thomas, C., Erni, R., Wu, J. Y., Fischer, F., Lamers, G., Grigolon, G., ... & Ristow, M. (2023). A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging. Nature Communications, 14(1), 8142. PMID:38065964 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10709416/ PMC:10709416] DOI:10.1038/s41467-023-43672-7</ref>
	Isofalcarintriol, like most C17-polyacetylene phytochemicals,<ref>Alfurayhi, R., Huang, L., & Brandt, K. (2023). Pathways Affected by Falcarinol-Type Polyacetylenes and Implications for Their Anti-Inflammatory Function and Potential in Cancer Chemoprevention. Foods, 12(6), 1192. {{PMID\|36981118~~}} {{~~PMC\|10048309~~}} {{~~DOI\|10.3390/foods12061192}}</ref><ref>Dawid, C., Dunemann, F., Schwab, W., Nothnagel, T., & Hofmann, T. (2015). Bioactive C17-polyacetylenes in carrots (Daucus carota L.): current knowledge and future perspectives. Journal of Agricultural and Food Chemistry, 63(42), 9211-9222. {{PMID\|26451696~~}} {{~~DOI\|10.1021/acs.jafc.5b04357}}</ref><ref>Christensen, L. P., & Brandt, K. (2006). Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. Journal of pharmaceutical and biomedical analysis, 41(3), 683-693. PMID: 16520011 DOI: 10.1016/j.jpba.2006.01.057</ref> can reduce risk of inflammation and cancer and thus ~~[[Life extension\|~~extends lifespan]] and promote health in models of age-associated diseases including diabetes, tumor cell growth, and of neurodegenerative diseases.<ref name="carrots" /><ref>Mandrich, L., Esposito, A. V., Costa, S., & Caputo, E. (2023). Chemical Composition, Functional and Anticancer Properties of Carrot. Molecules, 28(20), 7161. {{PMID\|37894640~~}} {{~~PMC\|10608851~~}} {{~~DOI\|10.3390/molecules28207161}}</ref>		Isofalcarintriol, like most C17-polyacetylene phytochemicals,<ref>Alfurayhi, R., Huang, L., & Brandt, K. (2023). Pathways Affected by Falcarinol-Type Polyacetylenes and Implications for Their Anti-Inflammatory Function and Potential in Cancer Chemoprevention. Foods, 12(6), 1192. PMID:36981118 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048309 PMC:10048309] DOI:10.3390/foods12061192</ref><ref>Dawid, C., Dunemann, F., Schwab, W., Nothnagel, T., & Hofmann, T. (2015). Bioactive C17-polyacetylenes in carrots (Daucus carota L.): current knowledge and future perspectives. Journal of Agricultural and Food Chemistry, 63(42), 9211-9222. PMID:26451696 DOI:10.1021/acs.jafc.5b04357</ref><ref>Christensen, L. P., & Brandt, K. (2006). Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. Journal of pharmaceutical and biomedical analysis, 41(3), 683-693. PMID: 16520011 DOI: 10.1016/j.jpba.2006.01.057</ref> can reduce risk of inflammation and cancer and thus extends lifespan and promote health in models of age-associated diseases including diabetes, tumor cell growth, and of neurodegenerative diseases.<ref name="carrots" /><ref>Mandrich, L., Esposito, A. V., Costa, S., & Caputo, E. (2023). Chemical Composition, Functional and Anticancer Properties of Carrot. Molecules, 28(20), 7161. PMID:37894640 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608851 PMC:10608851]
			DOI\|10.3390/molecules28207161</ref>

	Supplementation of isofalcarintriol to mice on high-fat diet improves glucose metabolism and		Supplementation of isofalcarintriol to mice on high-fat diet improves glucose metabolism and

Dmitry Dzhagarov at 11:39, 5 January 2024

2024-01-05T11:39:14Z

← Older revision		Revision as of 11:39, 5 January 2024
Line 11:		Line 11:
	\|}		\|}
	'''Isofalcarintriol''' ((3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol) is a polyacetylene contained in the root of carrots (Daucus carota), which was revealed as potent promoter of longevity in the nematode ''C. elegans'' even at remarkably low doses.<ref name="carrots" >Thomas, C., Erni, R., Wu, J. Y., Fischer, F., Lamers, G., Grigolon, G., ... & Ristow, M. (2023). A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging. Nature Communications, 14(1), 8142. PMID:38065964 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10709416/ PMC:10709416] DOI\|10.1038/s41467-023-43672-7</ref>		'''Isofalcarintriol''' ((3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol) is a polyacetylene contained in the root of carrots (Daucus carota), which was revealed as potent promoter of longevity in the nematode ''C. elegans'' even at remarkably low doses.<ref name="carrots" >Thomas, C., Erni, R., Wu, J. Y., Fischer, F., Lamers, G., Grigolon, G., ... & Ristow, M. (2023). A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging. Nature Communications, 14(1), 8142. PMID:38065964 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10709416/ PMC:10709416] DOI\|10.1038/s41467-023-43672-7</ref>
	Isofalcarintriol Life extension\|extends lifespan and ~~promotes~~ health in models of age-associated		Isofalcarintriol, like most C17-polyacetylene phytochemicals,<ref>Alfurayhi, R., Huang, L., & Brandt, K. (2023). Pathways Affected by Falcarinol-Type Polyacetylenes and Implications for Their Anti-Inflammatory Function and Potential in Cancer Chemoprevention. Foods, 12(6), 1192. {{PMID\|36981118}} {{PMC\|10048309}} {{DOI\|10.3390/foods12061192}}</ref><ref>Dawid, C., Dunemann, F., Schwab, W., Nothnagel, T., & Hofmann, T. (2015). Bioactive C17-polyacetylenes in carrots (Daucus carota L.): current knowledge and future perspectives. Journal of Agricultural and Food Chemistry, 63(42), 9211-9222. {{PMID\|26451696}} {{DOI\|10.1021/acs.jafc.5b04357}}</ref><ref>Christensen, L. P., & Brandt, K. (2006). Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. Journal of pharmaceutical and biomedical analysis, 41(3), 683-693. PMID: 16520011 DOI: 10.1016/j.jpba.2006.01.057</ref> can reduce risk of inflammation and cancer and thus [[Life extension\|extends lifespan]] and promote health in models of age-associated diseases including diabetes, tumor cell growth, and of neurodegenerative diseases.<ref name="carrots" /><ref>Mandrich, L., Esposito, A. V., Costa, S., & Caputo, E. (2023). Chemical Composition, Functional and Anticancer Properties of Carrot. Molecules, 28(20), 7161. {{PMID\|37894640}} {{PMC\|10608851}} {{DOI\|10.3390/molecules28207161}}</ref>
	diseases including diabetes, tumor cell growth, and of neurodegenerative diseases.<ref name="carrots" />

	Supplementation of isofalcarintriol to mice on high-fat diet improves glucose metabolism and		Supplementation of isofalcarintriol to mice on high-fat diet improves glucose metabolism and

Dmitry Dzhagarov at 06:49, 5 January 2024

2024-01-05T06:49:27Z

← Older revision		Revision as of 06:49, 5 January 2024
Line 10:		Line 10:
	\| Molecular Weight 278.39		\| Molecular Weight 278.39
	\|}		\|}
	'''Isofalcarintriol''' ((3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol) is a polyacetylene contained in the root of carrots (Daucus carota), which was revealed as potent promoter of longevity in the nematode ''C. elegans'' even at remarkably low doses.<ref name="carrots" >Thomas, C., Erni, R., Wu, J. Y., Fischer, F., Lamers, G., Grigolon, G., ... & Ristow, M. (2023). A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging. Nature Communications, 14(1), 8142. PMID:38065964 [ PMC\|10709416~~}} {{~~DOI\|10.1038/s41467-023-43672-7}}</ref>		'''Isofalcarintriol''' ((3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol) is a polyacetylene contained in the root of carrots (Daucus carota), which was revealed as potent promoter of longevity in the nematode ''C. elegans'' even at remarkably low doses.<ref name="carrots" >Thomas, C., Erni, R., Wu, J. Y., Fischer, F., Lamers, G., Grigolon, G., ... & Ristow, M. (2023). A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging. Nature Communications, 14(1), 8142. PMID:38065964 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10709416/ PMC:10709416] DOI\|10.1038/s41467-023-43672-7</ref>
	Isofalcarintriol [[Life extension\|extends lifespan]] and promotes health in models of age-associated		Isofalcarintriol Life extension\|extends lifespan and promotes health in models of age-associated
	diseases including diabetes, tumor cell growth, and of neurodegenerative diseases.<ref name="carrots" />		diseases including diabetes, tumor cell growth, and of neurodegenerative diseases.<ref name="carrots" />

	Supplementation of isofalcarintriol to mice on high-fat diet improves [[glucose~~]] [[~~metabolism]] and		Supplementation of isofalcarintriol to mice on high-fat diet improves glucose metabolism and
	increases murine exercise [[endurance]] during treadmill training, thus representing an		increases murine exercise endurance during treadmill training, thus representing an
	[[exercise mimetic]]. Interestingly, a similar trend was seen in isofalcarintriol-treated ~~[[Ageing\|~~aged]] mice, suggesting a potential improvement of [[frailty ~~syndrome~~]].<ref name="carrots" /> Isofalcarintriol treatment provoked an initial ROS signal and a subsequent activation of ~~[[NFE2L2\|~~nuclear factor erythroid 2-related factor 2 (Nrf2)]], eventually increasing [[oxidative stress]] resistance long term.<ref name="carrots" />		exercise mimetic. Interestingly, a similar trend was seen in isofalcarintriol-treated aged mice, suggesting a potential improvement of [[frailty]].<ref name="carrots" /> Isofalcarintriol treatment provoked an initial ROS signal and a subsequent activation of nuclear factor erythroid 2-related factor 2 (Nrf2), eventually increasing oxidative stress resistance long term.<ref name="carrots" />
	== References ==		== References ==
	<references />		<references />

Dmitry Dzhagarov: Created page with "{| class="wikitable" |- ! Isofalcarintriol |- | thumb |- | Formula C₁₇H₂₆O₃ |- | Molecular Weight 278.39 |} '''Isofalcarintriol''' ((3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol) is a polyacetylene contained in the root of carrots (Daucus carota), which was revealed as potent promoter of longevity in the nematode ''C. elegans'' even at remarkably low doses.Thomas, C., Erni,..."

2024-01-05T06:43:59Z

Created page with "{| class="wikitable" |- ! Isofalcarintriol |- | thumb |- | Formula C17H26O3 |- | Molecular Weight 278.39 |} '''Isofalcarintriol''' ((3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol) is a polyacetylene contained in the root of carrots (Daucus carota), which was revealed as potent promoter of longevity in the nematode ''C. elegans'' even at remarkably low doses.<ref name="carrots" >Thomas, C., Erni,..."

New page

{| class="wikitable"
|-
! Isofalcarintriol
|-
|
[[File:Isofalcarintriol.jpg|thumb]]
|-
| Formula C17H26O3
|-
| Molecular Weight 278.39
|}
'''Isofalcarintriol''' ((3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol) is a polyacetylene contained in the root of carrots (Daucus carota), which was revealed as potent promoter of longevity in the nematode ''C. elegans'' even at remarkably low doses.<ref name="carrots" >Thomas, C., Erni, R., Wu, J. Y., Fischer, F., Lamers, G., Grigolon, G., ... & Ristow, M. (2023). A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging. Nature Communications, 14(1), 8142. PMID:38065964 [ PMC|10709416}} {{DOI|10.1038/s41467-023-43672-7}}</ref>
Isofalcarintriol [[Life extension|extends lifespan]] and promotes health in models of age-associated
diseases including diabetes, tumor cell growth, and of neurodegenerative diseases.<ref name="carrots" />

Supplementation of isofalcarintriol to mice on high-fat diet improves [[glucose]] [[metabolism]] and
increases murine exercise [[endurance]] during treadmill training, thus representing an
[[exercise mimetic]]. Interestingly, a similar trend was seen in isofalcarintriol-treated [[Ageing|aged]] mice, suggesting a potential improvement of [[frailty syndrome]].<ref name="carrots" /> Isofalcarintriol treatment provoked an initial ROS signal and a subsequent activation of [[NFE2L2|nuclear factor erythroid 2-related factor 2 (Nrf2)]], eventually increasing [[oxidative stress]] resistance long term.<ref name="carrots" />
== References ==
<references />

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