LOY-001 - Revision history

Dmitry Dzhagarov at 12:42, 1 December 2023

2023-12-01T12:42:09Z

Dmitry Dzhagarov at 07:14, 1 December 2023

2023-12-01T07:14:54Z

Dmitry Dzhagarov at 04:38, 1 December 2023

2023-12-01T04:38:35Z

Dmitry Dzhagarov at 04:29, 1 December 2023

2023-12-01T04:29:07Z

Dmitry Dzhagarov: Created page with "'''LOY-001''' is the long-acting drug intended to extend lifespan and healthspan for large and giant breed dogs. A San Francisco-based biotech & veterinary medicine firm Loyal (November 28, 2023) [https://loyalfordogs.com/posts/loyal-announces-historic-fda-milestone-for-large-dog-lifespan-extension-drug FDA Center for Veterinary Medicine agrees Loyal’s data supports reasonable expectation of effectiveness for large dog lifespan extension]
2023-12-01T03:51:09Z

Created page with "'''LOY-001''' is the long-acting drug intended to extend lifespan and healthspan for large and giant breed dogs.<ref> A San Francisco-based biotech & veterinary medicine firm Loyal (November 28, 2023) [https://loyalfordogs.com/posts/loyal-announces-historic-fda-milestone-for-large-dog-lifespan-extension-drug FDA Center for Veterinary Medicine agrees Loyal’s data supports reasonable expectation of effectiveness for large dog lifespan extension]</..."

New page
'''LOY-001''' is the long-acting drug intended [[Dog Aging Project|to extend lifespan and healthspan for large and giant breed dogs]].<ref>
A San Francisco-based biotech & veterinary medicine firm Loyal (November 28, 2023) [https://loyalfordogs.com/posts/loyal-announces-historic-fda-milestone-for-large-dog-lifespan-extension-drug FDA Center for Veterinary Medicine agrees Loyal’s data supports reasonable expectation of effectiveness for large dog lifespan extension]</ref> LOY-001, is an injection-based treatment that targets Insulin-like growth factor 1 (IGF-1), also called somatomedin C. IGF-1 binds and activates its own receptor, IGF-1R, through the cell surface expression of Receptor Tyrosine Kinase's (RTK's)[20] and further signal through multiple intracellular transduction cascades. IGF-1R is the critical role-playing inducer in modulating the metabolic effects of IGF-1 for cellular senescence, longevity and survival.<ref>Junnila, R. K., List, E. O., Berryman, D. E., Murrey, J. W., & Kopchick, J. J. (2013). The GH/IGF-1 axis in ageing and longevity. Nature Reviews Endocrinology, 9(6), 366-376. PMID: 23591370 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074016/ PMC4074016] DOI: 10.1038/nrendo.2013.67</ref>

This hormone seems to be size-related—it appears in higher levels in larger dogs and in lower levels in smaller dogs and obviously this explains the fact that large and giant breed dogs have average life expectancies that are only half that of the smallest breeds.<ref>Socha, S., Mironska, M., & Kolodziejczyk, D. (2022). Analysis of factors affecting the quality and length of life of dogs. Acta Scientiarum Polonorum. Zootechnica, 21(3). DOI: 10.21005/asp.2022.21.3.01</ref><ref>Mazzatenta, A., Carluccio, A., Robbe, D., Di Giulio, C., & Cellerino, A. (2017). The companion dog as a unique translational model for aging. In Seminars in cell & developmental biology (Vol. 70, pp. 141-153). Academic Press. PMID: 28803893 [https://doi.org/10.1016/j.semcdb.2017.08.024 DOI: 10.1016/j.semcdb.2017.08.024]</ref> Research has shown that inhibiting IGF-1 in flies, worms and rodents can increase their lifespans.<ref>Duran-Ortiz, S., List, E. O., Basu, R., & Kopchick, J. J. (2021). Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age. Pituitary, 24(3), 438-456. PMID: 33459974 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122064/ PMC8122064] DOI: 10.1007/s11102-020-01117-0</ref><ref>Hou, Y. L., Wang, Y. F., Qiao, S. O. N. G., Zhang, X. M., Jing, L. I. U., Wang, Y. Q., ... & Wang, P. C. (2022). IGF-1 Accelerates Cell Aging by Inhibiting POLD1 Expression. Biomedical and Environmental Sciences, 35(11), 981-991. PMID: 36443251 [https://doi.org/10.3967/bes2022.127 DOI: 10.3967/bes2022.127]</ref>

LOY-001 is some kind of [[Long non-coding RNAs in aging and aging-associated diseases|antisense RNA]] designed for healthy dogs over the age of seven and above 40 pounds, and it would be administered every three to six months by a veterinarian.

[[Category:Lifespan interventions]]
[[Category:Drugs]]
[[Category:Longevity genes]]
[[Category:Main list]]