Mitophagy Inducing Coumarin (MIC) - Revision history

Dmitry Dzhagarov at 11:37, 15 November 2023

2023-11-15T11:37:13Z

← Older revision		Revision as of 11:37, 15 November 2023
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	'''Mitophagy Inducing Coumarin (MIC)''' is a benzocoumarin-based compound present in a high level in many edible plants and vegetables, which is capable of displaying a significant dose-dependent increase in TFEB (Transcription factor EB is a master gene for lysosomal biogenesis) promoter activity. MIC induces mitophagy and suppresses mitochondrial dysfunction, a major hallmark of aging, in both C. elegans and mammalian cell culture models.<ref>Chamoli, M., Rane, A., Foulger, A. et al. A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan. Nat Aging (2023). https://doi.org/10.1038/s43587-023-00524-9</ref> Mechanistically, MIC acts by inhibiting ligand-induced activation of the nuclear hormone receptor DAF-12/FXR (Farnesoid X Receptor upstream regulator of HLH-30/TFEB), which, in turn, induces mitophagy and extends lifespan. A clinically relevant, structurally related mitophagy inducer, urolithin A, was found to also engage DAF-12/FXR signaling in a similar manner. However, unlike urolithin A, which is produced from ingested ellagitannins by gut bacteria whose levels decrease with age, MIC is a naturally-occurring constituent of many plants including numerous vegetables and essential oils<ref>Chamoli, M., Rane, A., Chinta, S., Shahmirzadi, A., Kumsta, C., Nambiar, D., ... & Andersen, J. (2022). A drug-like molecule engages a nuclear hormone receptor to regulate mitophagy and promote mitochondrial mediated lifespan extension. : https://doi.org/10.21203/rs.3.rs-1840028/v1</ref>		'''Mitophagy Inducing Coumarin (MIC)''' is a benzocoumarin-based compound present in a high level in many edible plants and vegetables, which is capable of displaying a significant dose-dependent increase in TFEB (Transcription factor EB is a master gene for lysosomal biogenesis) promoter activity. MIC induces [[Autophagy#Mitophagy\|mitophagy]] and suppresses [[mitochondrial dysfunction]], a major [[Hallmarks of aging\|hallmark of aging]], in both ''C. elegans'' and mammalian cell culture models.<ref>Chamoli, M., Rane, A., Foulger, A. et al. A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan. Nat Aging (2023). https://doi.org/10.1038/s43587-023-00524-9</ref> Mechanistically, MIC acts by inhibiting ligand-induced activation of the nuclear hormone receptor DAF-12/FXR (Farnesoid X Receptor upstream regulator of HLH-30/TFEB), which, in turn, induces mitophagy and extends lifespan. A clinically relevant, structurally related mitophagy inducer, urolithin A, was found to also engage DAF-12/FXR signaling in a similar manner. However, unlike urolithin A, which is produced from ingested ellagitannins by gut bacteria whose levels decrease with age, MIC is a naturally-occurring constituent of many plants including numerous vegetables and essential oils<ref>Chamoli, M., Rane, A., Chinta, S., Shahmirzadi, A., Kumsta, C., Nambiar, D., ... & Andersen, J. (2022). A drug-like molecule engages a nuclear hormone receptor to regulate mitophagy and promote mitochondrial mediated lifespan extension. : https://doi.org/10.21203/rs.3.rs-1840028/v1</ref>

	[[Category:Glossary]]		[[Category:Glossary]]

Dmitry Dzhagarov at 11:31, 15 November 2023

2023-11-15T11:31:21Z

← Older revision		Revision as of 11:31, 15 November 2023
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	'''Mitophagy Inducing Coumarin (MIC)''' is a benzocoumarin-based compound present in a high level in many edible plants and vegetables, which is capable of displaying a significant dose-dependent increase in TFEB (Transcription factor EB is a master gene for lysosomal biogenesis) promoter activity. MIC induces mitophagy and suppresses mitochondrial dysfunction, a major hallmark of aging, in both C. elegans and mammalian cell culture models.<ref>Chamoli, M., Rane, A., Foulger, A. et al. A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan. Nat Aging (2023). https://doi.org/10.1038/s43587-023-00524-9</ref> Mechanistically, MIC acts by inhibiting ligand-induced activation of the nuclear hormone receptor DAF-12/FXR (Farnesoid X Receptor upstream regulator of HLH-30/TFEB), which, in turn, induces mitophagy and extends lifespan. A clinically relevant, structurally related mitophagy inducer, urolithin A, was found to also engage DAF-12/FXR signaling in a similar manner.<ref>Chamoli, M., Rane, A., Chinta, S., Shahmirzadi, A., Kumsta, C., Nambiar, D., ... & Andersen, J. (2022). A drug-like molecule engages a nuclear hormone receptor to regulate mitophagy and promote mitochondrial mediated lifespan extension. : https://doi.org/10.21203/rs.3.rs-1840028/v1</ref>		{\| class="wikitable"
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			'''Mitophagy Inducing Coumarin (MIC)''' is a benzocoumarin-based compound present in a high level in many edible plants and vegetables, which is capable of displaying a significant dose-dependent increase in TFEB (Transcription factor EB is a master gene for lysosomal biogenesis) promoter activity. MIC induces mitophagy and suppresses mitochondrial dysfunction, a major hallmark of aging, in both C. elegans and mammalian cell culture models.<ref>Chamoli, M., Rane, A., Foulger, A. et al. A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan. Nat Aging (2023). https://doi.org/10.1038/s43587-023-00524-9</ref> Mechanistically, MIC acts by inhibiting ligand-induced activation of the nuclear hormone receptor DAF-12/FXR (Farnesoid X Receptor upstream regulator of HLH-30/TFEB), which, in turn, induces mitophagy and extends lifespan. A clinically relevant, structurally related mitophagy inducer, urolithin A, was found to also engage DAF-12/FXR signaling in a similar manner. However, unlike urolithin A, which is produced from ingested ellagitannins by gut bacteria whose levels decrease with age, MIC is a naturally-occurring constituent of many plants including numerous vegetables and essential oils<ref>Chamoli, M., Rane, A., Chinta, S., Shahmirzadi, A., Kumsta, C., Nambiar, D., ... & Andersen, J. (2022). A drug-like molecule engages a nuclear hormone receptor to regulate mitophagy and promote mitochondrial mediated lifespan extension. : https://doi.org/10.21203/rs.3.rs-1840028/v1</ref>

	[[Category:Glossary]]		[[Category:Glossary]]

Dmitry Dzhagarov: Created page with "'''Mitophagy Inducing Coumarin (MIC)''' is a benzocoumarin-based compound present in a high level in many edible plants and vegetables, which is capable of displaying a significant dose-dependent increase in TFEB (Transcription factor EB is a master gene for lysosomal biogenesis) promoter activity. MIC induces mitophagy and suppresses mitochondrial dysfunction, a major hallmark of aging, in both C. elegans and mammalian cell culture models.Chamoli, M., Rane, A., Fou..."

2023-11-15T10:55:26Z

Created page with "'''Mitophagy Inducing Coumarin (MIC)''' is a benzocoumarin-based compound present in a high level in many edible plants and vegetables, which is capable of displaying a significant dose-dependent increase in TFEB (Transcription factor EB is a master gene for lysosomal biogenesis) promoter activity. MIC induces mitophagy and suppresses mitochondrial dysfunction, a major hallmark of aging, in both C. elegans and mammalian cell culture models.<ref>Chamoli, M., Rane, A., Fou..."

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'''Mitophagy Inducing Coumarin (MIC)''' is a benzocoumarin-based compound present in a high level in many edible plants and vegetables, which is capable of displaying a significant dose-dependent increase in TFEB (Transcription factor EB is a master gene for lysosomal biogenesis) promoter activity. MIC induces mitophagy and suppresses mitochondrial dysfunction, a major hallmark of aging, in both C. elegans and mammalian cell culture models.<ref>Chamoli, M., Rane, A., Foulger, A. et al. A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan. Nat Aging (2023). https://doi.org/10.1038/s43587-023-00524-9</ref> Mechanistically, MIC acts by inhibiting ligand-induced activation of the nuclear hormone receptor DAF-12/FXR (Farnesoid X Receptor upstream regulator of HLH-30/TFEB), which, in turn, induces mitophagy and extends lifespan. A clinically relevant, structurally related mitophagy inducer, urolithin A, was found to also engage DAF-12/FXR signaling in a similar manner.<ref>Chamoli, M., Rane, A., Chinta, S., Shahmirzadi, A., Kumsta, C., Nambiar, D., ... & Andersen, J. (2022). A drug-like molecule engages a nuclear hormone receptor to regulate mitophagy and promote mitochondrial mediated lifespan extension. : https://doi.org/10.21203/rs.3.rs-1840028/v1</ref>

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[[Category:Lifespan interventions]]
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