Dmitry Dzhagarov at 12:14, 18 July 2024

2024-07-18T12:14:18Z

← Older revision		Revision as of 12:14, 18 July 2024
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	'''Nicotinamide N-methyltransferase inhibitors (NNMTis)''' treatment could surpass the muscle health benefits of resistance and endurance exercise. NNMTi treatment prevents age-associated loss of strength and actively rebuilds strength. Moreover, NNMTi treatment almost doubled the increase in muscle strength compared to exercise alone. The increases in muscle strength resulting from NNMTi treatment or exercise were additive, with the strength of the NNMTi-treated exercise cohort being increased by ~ 60% compared to the control cohort.<ref>Dimet-Wiley, A.L., Latham, C.M., Brightwell, C.R. et al. (2024). Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Sci Rep 14, 15554 https://doi.org/10.1038/s41598-024-66034-9</ref> These studies suggest that NNMTi-based drugs, either alone or combined with exercise, will be beneficial in treating sarcopenia and a wide range of age-related myopathies.		'''Nicotinamide N-methyltransferase inhibitors (NNMTis)''' treatment could surpass the muscle health benefits of resistance and endurance exercise. NNMTi (5-amino-1-methylquinolinium iodide<ref>Neelakantan, H., Wang, H. Y., Vance, V., Hommel, J. D., McHardy, S. F., & Watowich, S. J. (2017). Structure–activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. Journal of medicinal chemistry, 60(12), 5015-5028.</ref>) treatment prevents age-associated loss of strength and actively rebuilds strength. Moreover, NNMTi treatment almost doubled the increase in muscle strength compared to exercise alone. The increases in muscle strength resulting from NNMTi treatment or exercise were additive, with the strength of the NNMTi-treated exercise cohort being increased by ~ 60% compared to the control cohort.<ref>Dimet-Wiley, A.L., Latham, C.M., Brightwell, C.R. et al. (2024). Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Sci Rep 14, 15554 https://doi.org/10.1038/s41598-024-66034-9</ref> These studies suggest that NNMTi-based drugs, either alone or combined with exercise, will be beneficial in treating sarcopenia and a wide range of age-related myopathies.

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Dmitry Dzhagarov: Created page with "'''Nicotinamide N-methyltransferase inhibitors (NNMTis)''' treatment could surpass the muscle health benefits of resistance and endurance exercise. NNMTi treatment prevents age-associated loss of strength and actively rebuilds strength. Moreover, NNMTi treatment almost doubled the increase in muscle strength compared to exercise alone. The increases in muscle strength resulting from NNMTi treatment or exercise were additive, with the strength of the NNMTi-treated exercis..."

2024-07-17T06:46:06Z

Created page with "'''Nicotinamide N-methyltransferase inhibitors (NNMTis)''' treatment could surpass the muscle health benefits of resistance and endurance exercise. NNMTi treatment prevents age-associated loss of strength and actively rebuilds strength. Moreover, NNMTi treatment almost doubled the increase in muscle strength compared to exercise alone. The increases in muscle strength resulting from NNMTi treatment or exercise were additive, with the strength of the NNMTi-treated exercis..."

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'''Nicotinamide N-methyltransferase inhibitors (NNMTis)''' treatment could surpass the muscle health benefits of resistance and endurance exercise. NNMTi treatment prevents age-associated loss of strength and actively rebuilds strength. Moreover, NNMTi treatment almost doubled the increase in muscle strength compared to exercise alone. The increases in muscle strength resulting from NNMTi treatment or exercise were additive, with the strength of the NNMTi-treated exercise cohort being increased by ~ 60% compared to the control cohort.<ref>Dimet-Wiley, A.L., Latham, C.M., Brightwell, C.R. et al. (2024). Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Sci Rep 14, 15554 https://doi.org/10.1038/s41598-024-66034-9</ref> These studies suggest that NNMTi-based drugs, either alone or combined with exercise, will be beneficial in treating sarcopenia and a wide range of age-related myopathies.

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[[Category:Drugs]]

Nicotinamide N-methyltransferase inhibitors (NNMTis) - Revision history

Dmitry Dzhagarov at 12:14, 18 July 2024