Pentadecanoic Acid (C15: 0) - Revision history

Dmitry Dzhagarov: /* References */

2024-08-13T19:13:35Z

References

← Older revision		Revision as of 19:13, 13 August 2024
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	<ref>Venn-Watson SK, Butterworth CN (2022) Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems. PLoS ONE 17(5): e0268778. https://doi.org/10.1371/journal.pone.0268778</ref>		<ref>Venn-Watson SK, Butterworth CN (2022) Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems. PLoS ONE 17(5): e0268778. https://doi.org/10.1371/journal.pone.0268778</ref>

			=== See also: ===
			[https://longevity.technology/news/c150-combats-cellular-fragility-syndrome-obesity-and-aging/ Raising levels of fatty acid C15:0 through supplementation can improve metabolic health and combat cellular aging.]

	== References ==		== References ==

Dmitry Dzhagarov at 20:41, 10 November 2023

2023-11-10T20:41:08Z

← Older revision		Revision as of 20:41, 10 November 2023
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			{\| class="wikitable"
			\|+ Molar mass 242.403 g·mol<sup>−1</sup>
			\|-
			! Pentadecanoic Acid (C15: 0) C<sub>15</sub>H<sub>30</sub>O<sub>2</sub>
			\|-
			\| [[File:Pentadecanoic acid (C15-0).jpg\|250px]]
			\|-
			\| CASNo = 1002-84-2
			\|-
			\| PubChem = 13849
			\|}
	'''Pentadecanoic Acid (C15: 0)''', also known as '''pentadecylic acid''', is a fatty acid, like omega-3 and omega-6, but unlike them, pentadecanoic acid (C15: 0) has no double bonds in its main chain, making it a resilient molecule that is resistant to oxidation.<ref name="resistant" >Venn-Watson, S. K., & Butterworth, C. N. (2022). Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems. PloS one, 17(5), e0268778. PMID: 35617322 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135213/ PMC9135213] DOI: 10.1371/journal.pone.0268778</ref><ref name="Leading" >Venn-Watson, S., & Schork, N. J. (2023). Pentadecanoic Acid (C15: 0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds. Nutrients, 15(21), 4607. https://doi.org/10.3390/nu15214607</ref>		'''Pentadecanoic Acid (C15: 0)''', also known as '''pentadecylic acid''', is a fatty acid, like omega-3 and omega-6, but unlike them, pentadecanoic acid (C15: 0) has no double bonds in its main chain, making it a resilient molecule that is resistant to oxidation.<ref name="resistant" >Venn-Watson, S. K., & Butterworth, C. N. (2022). Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems. PloS one, 17(5), e0268778. PMID: 35617322 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135213/ PMC9135213] DOI: 10.1371/journal.pone.0268778</ref><ref name="Leading" >Venn-Watson, S., & Schork, N. J. (2023). Pentadecanoic Acid (C15: 0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds. Nutrients, 15(21), 4607. https://doi.org/10.3390/nu15214607</ref>
	Pentadecylic acid occurs in hydrogenated mutton fat, ruminant meat, some types of fish, milk fat from cows and some plants.<ref name="dietary" >Venn-Watson, S., Lumpkin, R., & Dennis, E. A. (2020). Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?. Scientific reports, 10(1), 8161. PMID: 32424181 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235264/ PMC7235264] DOI: 10.1038/s41598-020-64960-y</ref><ref>Jenkins, B., West, J. A., & Koulman, A. (2015). A review of odd-chain fatty acid metabolism and the role of pentadecanoic acid (C15: 0) and heptadecanoic acid (C17: 0) in health and disease. Molecules, 20(2), 2425-2444. PMID: 25647578 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272531 PMC6272531] DOI: 10.3390/molecules20022425</ref>		Pentadecylic acid occurs in hydrogenated mutton fat, ruminant meat, some types of fish, milk fat from cows and some plants.<ref name="dietary" >Venn-Watson, S., Lumpkin, R., & Dennis, E. A. (2020). Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?. Scientific reports, 10(1), 8161. PMID: 32424181 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235264/ PMC7235264] DOI: 10.1038/s41598-020-64960-y</ref><ref>Jenkins, B., West, J. A., & Koulman, A. (2015). A review of odd-chain fatty acid metabolism and the role of pentadecanoic acid (C15: 0) and heptadecanoic acid (C17: 0) in health and disease. Molecules, 20(2), 2425-2444. PMID: 25647578 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272531 PMC6272531] DOI: 10.3390/molecules20022425</ref>

Dmitry Dzhagarov at 19:30, 10 November 2023

2023-11-10T19:30:58Z

← Older revision		Revision as of 19:30, 10 November 2023
Line 1:		Line 1:
	'''Pentadecanoic Acid (C15: 0)''', also known as '''pentadecylic acid''', is a fatty acid, like omega-3 and omega-6, but unlike them, pentadecanoic acid (C15: 0) has no double bonds in its main chain, making it a resilient molecule that is resistant to oxidation.<ref name="resistant" >Venn-Watson, S. K., & Butterworth, C. N. (2022). Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems. PloS one, 17(5), e0268778. PMID: 35617322 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135213/ PMC9135213] DOI: 10.1371/journal.pone.0268778</ref><ref name="Leading" >Venn-Watson, S., & Schork, N. J. (2023). Pentadecanoic Acid (C15: 0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds. Nutrients, 15(21), 4607. https://doi.org/10.3390/nu15214607</ref>		'''Pentadecanoic Acid (C15: 0)''', also known as '''pentadecylic acid''', is a fatty acid, like omega-3 and omega-6, but unlike them, pentadecanoic acid (C15: 0) has no double bonds in its main chain, making it a resilient molecule that is resistant to oxidation.<ref name="resistant" >Venn-Watson, S. K., & Butterworth, C. N. (2022). Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems. PloS one, 17(5), e0268778. PMID: 35617322 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135213/ PMC9135213] DOI: 10.1371/journal.pone.0268778</ref><ref name="Leading" >Venn-Watson, S., & Schork, N. J. (2023). Pentadecanoic Acid (C15: 0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds. Nutrients, 15(21), 4607. https://doi.org/10.3390/nu15214607</ref>
	Pentadecylic acid occurs in hydrogenated mutton fat, ruminant meat, some types of fish, milk fat from cows and some plants.<ref name="dietary" >Venn-Watson, S., Lumpkin, R., & Dennis, E. A. (2020). Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?. Scientific reports, 10(1), 8161. PMID: 32424181 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235264/ PMC7235264] DOI: 10.1038/s41598-020-64960-y</ref>		Pentadecylic acid occurs in hydrogenated mutton fat, ruminant meat, some types of fish, milk fat from cows and some plants.<ref name="dietary" >Venn-Watson, S., Lumpkin, R., & Dennis, E. A. (2020). Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?. Scientific reports, 10(1), 8161. PMID: 32424181 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235264/ PMC7235264] DOI: 10.1038/s41598-020-64960-y</ref><ref>Jenkins, B., West, J. A., & Koulman, A. (2015). A review of odd-chain fatty acid metabolism and the role of pentadecanoic acid (C15: 0) and heptadecanoic acid (C17: 0) in health and disease. Molecules, 20(2), 2425-2444. PMID: 25647578 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272531 PMC6272531] DOI: 10.3390/molecules20022425</ref>

	In 2005, Hulbert<ref name="Hulbert" >Hulbert, A. J. , Pamplona, R. , Buffenstein, R. , & Buttemer, W. A. (2007). Life and death: Metabolic rate, membrane composition, and life span of animals. Physiological Reviews, 87, 1175–1213. PMID: 17928583 DOI: 10.1152/physrev.00047.2006</ref> proposed the membrane pacemaker theory of aging. This theory emphasizes that the fatty acid composition of membranes is a critical factor in lipid peroxidation and consequently in the rate of aging and determination of lifespan. Indeed, it has been suggested that the specific acyl composition of membranes works as a timer to determinate longevity in different species. Long-lived animals have a low degree of fatty acid unsaturation in cell membranes due to decreases in PUFAs and higher levels of less unsaturated fatty acids,<ref name="Hulbert" /> changes that make them more resistant to lipid peroxidation in vivo.<ref>Pamplona, R., & Barja, G. (2007). Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevity. Ageing research reviews, 6(3), 189-210. PMID: 17702671 DOI: 10.1016/j.arr.2007.06.002</ref><ref>Martín, M. G., & Dotti, C. G. (2022). Plasma membrane and brain dysfunction of the old: Do we age from our membranes?. Frontiers in cell and developmental biology, 10, 1031007. PMID: 36274849 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582647 PMC9582647] DOI: 10.3389/fcell.2022.1031007</ref>		In 2005, Hulbert<ref name="Hulbert" >Hulbert, A. J. , Pamplona, R. , Buffenstein, R. , & Buttemer, W. A. (2007). Life and death: Metabolic rate, membrane composition, and life span of animals. Physiological Reviews, 87, 1175–1213. PMID: 17928583 DOI: 10.1152/physrev.00047.2006</ref> proposed the membrane pacemaker theory of aging. This theory emphasizes that the fatty acid composition of membranes is a critical factor in lipid peroxidation and consequently in the rate of aging and determination of lifespan. Indeed, it has been suggested that the specific acyl composition of membranes works as a timer to determinate longevity in different species. Long-lived animals have a low degree of fatty acid unsaturation in cell membranes due to decreases in PUFAs and higher levels of less unsaturated fatty acids,<ref name="Hulbert" /> changes that make them more resistant to lipid peroxidation in vivo.<ref>Pamplona, R., & Barja, G. (2007). Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevity. Ageing research reviews, 6(3), 189-210. PMID: 17702671 DOI: 10.1016/j.arr.2007.06.002</ref><ref>Martín, M. G., & Dotti, C. G. (2022). Plasma membrane and brain dysfunction of the old: Do we age from our membranes?. Frontiers in cell and developmental biology, 10, 1031007. PMID: 36274849 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582647 PMC9582647] DOI: 10.3389/fcell.2022.1031007</ref>

			<ref>Venn-Watson SK, Butterworth CN (2022) Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems. PLoS ONE 17(5): e0268778. https://doi.org/10.1371/journal.pone.0268778</ref>

	== References ==		== References ==

Dmitry Dzhagarov: Created page with "'''Pentadecanoic Acid (C15: 0)''', also known as '''pentadecylic acid''', is a fatty acid, like omega-3 and omega-6, but unlike them, pentadecanoic acid (C15: 0) has no double bonds in its main chain, making it a resilient molecule that is resistant to oxidation.Venn-Watson, S. K., & Butterworth, C. N. (2022). Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid a..."

2023-11-10T19:11:51Z

Created page with "'''Pentadecanoic Acid (C15: 0)''', also known as '''pentadecylic acid''', is a fatty acid, like omega-3 and omega-6, but unlike them, pentadecanoic acid (C15: 0) has no double bonds in its main chain, making it a resilient molecule that is resistant to oxidation.<ref name="resistant" >Venn-Watson, S. K., & Butterworth, C. N. (2022). Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid a..."

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'''Pentadecanoic Acid (C15: 0)''', also known as '''pentadecylic acid''', is a fatty acid, like omega-3 and omega-6, but unlike them, pentadecanoic acid (C15: 0) has no double bonds in its main chain, making it a resilient molecule that is resistant to oxidation.<ref name="resistant" >Venn-Watson, S. K., & Butterworth, C. N. (2022). Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems. PloS one, 17(5), e0268778. PMID: 35617322 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135213/ PMC9135213] DOI: 10.1371/journal.pone.0268778</ref><ref name="Leading" >Venn-Watson, S., & Schork, N. J. (2023). Pentadecanoic Acid (C15: 0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds. Nutrients, 15(21), 4607. https://doi.org/10.3390/nu15214607</ref>
Pentadecylic acid occurs in hydrogenated mutton fat, ruminant meat, some types of fish, milk fat from cows and some plants.<ref name="dietary" >Venn-Watson, S., Lumpkin, R., & Dennis, E. A. (2020). Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?. Scientific reports, 10(1), 8161. PMID: 32424181 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235264/ PMC7235264] DOI: 10.1038/s41598-020-64960-y</ref>

In 2005, Hulbert<ref name="Hulbert" >Hulbert, A. J. , Pamplona, R. , Buffenstein, R. , & Buttemer, W. A. (2007). Life and death: Metabolic rate, membrane composition, and life span of animals. Physiological Reviews, 87, 1175–1213. PMID: 17928583 DOI: 10.1152/physrev.00047.2006</ref> proposed the membrane pacemaker theory of aging. This theory emphasizes that the fatty acid composition of membranes is a critical factor in lipid peroxidation and consequently in the rate of aging and determination of lifespan. Indeed, it has been suggested that the specific acyl composition of membranes works as a timer to determinate longevity in different species. Long-lived animals have a low degree of fatty acid unsaturation in cell membranes due to decreases in PUFAs and higher levels of less unsaturated fatty acids,<ref name="Hulbert" /> changes that make them more resistant to lipid peroxidation in vivo.<ref>Pamplona, R., & Barja, G. (2007). Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevity. Ageing research reviews, 6(3), 189-210. PMID: 17702671 DOI: 10.1016/j.arr.2007.06.002</ref><ref>Martín, M. G., & Dotti, C. G. (2022). Plasma membrane and brain dysfunction of the old: Do we age from our membranes?. Frontiers in cell and developmental biology, 10, 1031007. PMID: 36274849 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582647 PMC9582647] DOI: 10.3389/fcell.2022.1031007</ref>

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