Pigment epithelium-derived factor (PEDF) - Revision history

Dmitry Dzhagarov at 20:09, 6 May 2024

2024-05-06T20:09:56Z

← Older revision		Revision as of 20:09, 6 May 2024
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	'''Pigment epithelium-derived factor (PEDF)''' is a 50 kDa secreted glycoprotein that belongs to the non-inhibitory group of the serine protease inhibitor (SERPIN) superfamily.<ref>Filleur, S., Nelius, T. I. O. V. S., De Riese, W., & Kennedy, R. C. (2009). Characterization of PEDF: a multi‐functional serpin family protein. Journal of cellular biochemistry, 106(5), 769-775. https://doi.org/10.1002/jcb.22072</ref> PEDF plays an important role in mediating cellular protection during exposure to oxidative stress and inflammation by preventing stress-induced angiogenesis and apoptosis.<ref>Brook, N., Brook, E., Dharmarajan, A., Chan, A., & Dass, C. R. (2019). The role of pigment epithelium-derived factor in protecting against cellular stress. Free Radical Research, 53(11–12), 1166–1180. https://doi.org/10.1080/10715762.2019.1697809</ref>		'''Pigment epithelium-derived factor (PEDF)''' is a 50 kDa secreted glycoprotein that belongs to the non-inhibitory group of the serine protease inhibitor (SERPIN) superfamily.<ref>Filleur, S., Nelius, T. I. O. V. S., De Riese, W., & Kennedy, R. C. (2009). Characterization of PEDF: a multi‐functional serpin family protein. Journal of cellular biochemistry, 106(5), 769-775. https://doi.org/10.1002/jcb.22072</ref> PEDF plays an important role in mediating cellular protection during exposure to oxidative stress and inflammation by preventing stress-induced angiogenesis and apoptosis.<ref>Brook, N., Brook, E., Dharmarajan, A., Chan, A., & Dass, C. R. (2019). The role of pigment epithelium-derived factor in protecting against cellular stress. Free Radical Research, 53(11–12), 1166–1180. https://doi.org/10.1080/10715762.2019.1697809</ref>
	PEDF is the most potent anti-angiogenic agent currently known, twice as potent as angiostatin.<ref>Li, R., Weng, X., Hu, X., Wang, J., & Zheng, L. (2024). Pigment epithelium‑derived factor inhibits proliferation, invasion and angiogenesis, and induces ferroptosis of extravillous trophoblasts by targeting Wnt‑β‑catenin/VEGF signaling in placenta accreta spectrum. Molecular Medicine Reports, 29(5), 1-10. PMID: 38488028 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10975022/ PMC10975022] DOI: 10.3892/mmr.2024.13199</ref>		PEDF is the most potent anti-angiogenic agent currently known, twice as potent as angiostatin.<ref>Li, R., Weng, X., Hu, X., Wang, J., & Zheng, L. (2024). Pigment epithelium‑derived factor inhibits proliferation, invasion and angiogenesis, and induces ferroptosis of extravillous trophoblasts by targeting Wnt‑β‑catenin/VEGF signaling in placenta accreta spectrum. Molecular Medicine Reports, 29(5), 1-10. PMID: 38488028 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10975022/ PMC10975022] DOI: 10.3892/mmr.2024.13199</ref>

			<ref>Wang X., Tazearslan C., Kim S., et al., (2024). In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood. bioRxiv.592258; doi: https://doi.org/10.1101/2024.05.02.592258</ref>

	== References ==		== References ==

Dmitry Dzhagarov at 20:00, 6 May 2024

2024-05-06T20:00:16Z

← Older revision		Revision as of 20:00, 6 May 2024
Line 1:		Line 1:
	'''Pigment epithelium-derived factor (PEDF)''' is a 50 kDa secreted glycoprotein that belongs to the non-inhibitory group of the serine protease inhibitor (SERPIN) superfamily.<ref>Filleur, S., Nelius, T. I. O. V. S., De Riese, W., & Kennedy, R. C. (2009). Characterization of PEDF: a multi‐functional serpin family protein. Journal of cellular biochemistry, 106(5), 769-775. https://doi.org/10.1002/jcb.22072</ref> PEDF plays an important role in mediating cellular protection during exposure to oxidative stress and inflammation by preventing stress-induced angiogenesis and apoptosis.<ref>Brook, N., Brook, E., Dharmarajan, A., Chan, A., & Dass, C. R. (2019). The role of pigment epithelium-derived factor in protecting against cellular stress. Free Radical Research, 53(11–12), 1166–1180. https://doi.org/10.1080/10715762.2019.1697809</ref>		'''Pigment epithelium-derived factor (PEDF)''' is a 50 kDa secreted glycoprotein that belongs to the non-inhibitory group of the serine protease inhibitor (SERPIN) superfamily.<ref>Filleur, S., Nelius, T. I. O. V. S., De Riese, W., & Kennedy, R. C. (2009). Characterization of PEDF: a multi‐functional serpin family protein. Journal of cellular biochemistry, 106(5), 769-775. https://doi.org/10.1002/jcb.22072</ref> PEDF plays an important role in mediating cellular protection during exposure to oxidative stress and inflammation by preventing stress-induced angiogenesis and apoptosis.<ref>Brook, N., Brook, E., Dharmarajan, A., Chan, A., & Dass, C. R. (2019). The role of pigment epithelium-derived factor in protecting against cellular stress. Free Radical Research, 53(11–12), 1166–1180. https://doi.org/10.1080/10715762.2019.1697809</ref>
			PEDF is the most potent anti-angiogenic agent currently known, twice as potent as angiostatin.<ref>Li, R., Weng, X., Hu, X., Wang, J., & Zheng, L. (2024). Pigment epithelium‑derived factor inhibits proliferation, invasion and angiogenesis, and induces ferroptosis of extravillous trophoblasts by targeting Wnt‑β‑catenin/VEGF signaling in placenta accreta spectrum. Molecular Medicine Reports, 29(5), 1-10. PMID: 38488028 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10975022/ PMC10975022] DOI: 10.3892/mmr.2024.13199</ref>

	== References ==		== References ==

Dmitry Dzhagarov: Created page with "'''Pigment epithelium-derived factor (PEDF)''' is a 50 kDa secreted glycoprotein that belongs to the non-inhibitory group of the serine protease inhibitor (SERPIN) superfamily.Filleur, S., Nelius, T. I. O. V. S., De Riese, W., & Kennedy, R. C. (2009). Characterization of PEDF: a multi‐functional serpin family protein. Journal of cellular biochemistry, 106(5), 769-775. https://doi.org/10.1002/jcb.22072 PEDF plays an important role in mediating cellular protec..."

2024-05-06T18:59:32Z

Created page with "'''Pigment epithelium-derived factor (PEDF)''' is a 50 kDa secreted glycoprotein that belongs to the non-inhibitory group of the serine protease inhibitor (SERPIN) superfamily.<ref>Filleur, S., Nelius, T. I. O. V. S., De Riese, W., & Kennedy, R. C. (2009). Characterization of PEDF: a multi‐functional serpin family protein. Journal of cellular biochemistry, 106(5), 769-775. https://doi.org/10.1002/jcb.22072</ref> PEDF plays an important role in mediating cellular protec..."

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'''Pigment epithelium-derived factor (PEDF)''' is a 50 kDa secreted glycoprotein that belongs to the non-inhibitory group of the serine protease inhibitor (SERPIN) superfamily.<ref>Filleur, S., Nelius, T. I. O. V. S., De Riese, W., & Kennedy, R. C. (2009). Characterization of PEDF: a multi‐functional serpin family protein. Journal of cellular biochemistry, 106(5), 769-775. https://doi.org/10.1002/jcb.22072</ref> PEDF plays an important role in mediating cellular protection during exposure to oxidative stress and inflammation by preventing stress-induced angiogenesis and apoptosis.<ref>Brook, N., Brook, E., Dharmarajan, A., Chan, A., & Dass, C. R. (2019). The role of pigment epithelium-derived factor in protecting against cellular stress. Free Radical Research, 53(11–12), 1166–1180. https://doi.org/10.1080/10715762.2019.1697809</ref>

== References ==
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