Preventing muscle loss - Revision history

Dmitry Dzhagarov at 18:11, 1 September 2024

2024-09-01T18:11:12Z

← Older revision		Revision as of 18:11, 1 September 2024
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	'''Preventing muscle loss'''		'''Preventing muscle loss'''
			'''Sarcopenia''' - an age-related disease characterized by loss of muscle strength, mass and performance is frequently associated with aging and plays a major role in the development of frailty syndrome.<ref>Damanti, S., Citterio, L., Zagato, L., Brioni, E., Magnaghi, C., Simonini, M., ... & Querini, P. R. (2024). Sarcopenic obesity and pre-sarcopenia contribute to frailty in community-dwelling Italian older people: data from the FRASNET study. BMC geriatrics, 24(1), 638. PMID: 39085777 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290298/ PMC11290298] DOI: 10.1186/s12877-024-05216-6</ref><ref>Heng, M. W. Y., Chan, A. W., Man, R. E., Fenwick, E. K., Chew, S. T., Tay, L., ... & Lamoureux, E. L. (2023). Individual and combined associations of sarcopenia, osteoporosis and obesity with frailty in a multi-ethnic asian older adult population. BMC geriatrics, 23(1), 802.</ref>
	Skeletal muscle atrophy is characterized by weakening, shrinking, and decreasing muscle mass and fiber cross-sectional area at the histological level. It manifests as a reduction in force production, easy fatigue and decreased exercise capability, along with a lower quality of life.		Skeletal muscle atrophy is characterized by weakening, shrinking, and decreasing muscle mass and fiber cross-sectional area at the histological level. It manifests as a reduction in force production, easy fatigue and decreased exercise capability, along with a lower quality of life.
	'''Exercise''' is widely acknowledged as '''the most effective therapy for skeletal muscle atrophy'''; unfortunately, it is not applicable for all patients. Several active substances for skeletal muscle atrophy have been discovered and evaluated in clinical trials, however, they have not been marketed to date.		'''Exercise''' with protein supplementation is widely acknowledged as '''the most effective therapy for skeletal muscle atrophy''';<ref>Yamada, M., Kimura, Y., Ishiyama, D., Nishio, N., Otobe, Y., Tanaka, T., ... & Arai, H. (2019). Synergistic effect of bodyweight resistance exercise and protein supplementation on skeletal muscle in sarcopenic or dynapenic older adults. Geriatrics & gerontology international, 19(5), 429-437. PMID: 30864254 DOI: 10.1111/ggi.13643</ref><ref>Liao, C. D., Huang, S. W., Chen, H. C., Huang, M. H., Liou, T. H., & Lin, C. L. (2024). Comparative Efficacy of Different Protein Supplements on Muscle Mass, Strength, and Physical Indices of Sarcopenia among Community-Dwelling, Hospitalized or Institutionalized Older Adults Undergoing Resistance Training: A Network Meta-Analysis of Randomized Controlled Trials. Nutrients, 16(7), 941. PMID: 38612975 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11013298/ PMC11013298] DOI: 10.3390/nu16070941</ref> unfortunately, it is not applicable for all patients. Several active substances for skeletal muscle atrophy have been discovered and evaluated in clinical trials, however, they have not been marketed to date.<ref>Najm, A., Niculescu, A. G., Grumezescu, A. M., & Beuran, M. (2024). Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advances. International Journal of Molecular Sciences, 25(8), 4300. PMID: 38673885 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11050002/ PMC11050002] DOI: 10.3390/ijms25084300</ref>
			Nutritional supplements play a pivotal role in the current management of sarcopenia. The leucine metabolite '''β-hydroxy-β-methylbutyric acid (HMB)''' supplement is one of the most extensively studied interventions for attenuating the progression of sarcopenia.

	== Plant-derived bioactive compounds beneficial in preventing muscle loss and restoring muscle function ==		== Plant-derived bioactive compounds beneficial in preventing muscle loss and restoring muscle function ==
	# '''triptolide''' <ref>Fang, W. Y., Tseng, Y. T., Lee, T. Y., Fu, Y. C., Chang, W. H., Lo, W. W., ... & Lo, Y. C. (2021). Triptolide prevents LPS‐induced skeletal muscle atrophy via inhibiting NF‐κB/TNF‐α and regulating protein synthesis/degradation pathway. British Journal of Pharmacology, 178(15), 2998-3016. PMID: 33788266 DOI: 10.1111/bph.15472</ref>
	# '''myricanol''' <ref>Shen, S., Liao, Q., Lyu, P., Wang, J., & Lin, L. (2024). Myricanol prevents aging‐related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5. MedComm, 5(6), e566. PMID: 38868327 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167181/ PMC11167181] DOI: 10.1002/mco2.566</ref>		# '''myricanol''' <ref>Shen, S., Liao, Q., Lyu, P., Wang, J., & Lin, L. (2024). Myricanol prevents aging‐related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5. MedComm, 5(6), e566. PMID: 38868327 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167181/ PMC11167181] DOI: 10.1002/mco2.566</ref>
	# '''tomatidine''' <ref>Dyle, M. C., Ebert, S. M., Cook, D. P., Kunkel, S. D., Fox, D. K., Bongers, K. S., ... & Adams, C. M. (2014). Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy. Journal of Biological Chemistry, 289(21), 14913-14924. PMID: 24719321 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031541/ PMC4031541] DOI: 10.1074/jbc.M114.556241</ref>		# '''tomatidine''' <ref>Dyle, M. C., Ebert, S. M., Cook, D. P., Kunkel, S. D., Fox, D. K., Bongers, K. S., ... & Adams, C. M. (2014). Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy. Journal of Biological Chemistry, 289(21), 14913-14924. PMID: 24719321 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031541/ PMC4031541] DOI: 10.1074/jbc.M114.556241</ref>
	# '''carnosol''' <ref>Lu, S., Li, Y., Shen, Q., Zhang, W., Gu, X., Ma, M., ... & Zhang, X. (2021). Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia. Journal of cachexia, sarcopenia and muscle, 12(3), 779-795. </ref> exhibited anticachexia effects mainly by inhibiting TNF-α/NF-κB pathway and decreasing muscle and adipose tissue loss. Carnosol might also ameliorate cancer cachexia-associated myotube atrophy by targeting P5CS (Delta-1-pyrroline-5-carboxylate synthase) and its downstream pathways.<ref>Fang, Q. Y., Wang, Y. P., Zhang, R. Q., Fan, M., Feng, L. X., Guo, X. D., ... & Liu, X. (2024). Carnosol ameliorated cancer cachexia-associated myotube atrophy by targeting P5CS and its downstream pathways. Frontiers in Pharmacology, 14, 1291194. PMID: 38249348 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10799341/ PMC10799341] DOI: 10.3389/fphar.2023.1291194</ref>		# '''carnosol''' <ref>Lu, S., Li, Y., Shen, Q., Zhang, W., Gu, X., Ma, M., ... & Zhang, X. (2021). Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia. Journal of cachexia, sarcopenia and muscle, 12(3), 779-795. </ref> exhibited anticachexia effects mainly by inhibiting TNF-α/NF-κB pathway and decreasing muscle and adipose tissue loss. Carnosol might also ameliorate cancer cachexia-associated myotube atrophy by targeting P5CS (Delta-1-pyrroline-5-carboxylate synthase) and its downstream pathways.<ref>Fang, Q. Y., Wang, Y. P., Zhang, R. Q., Fan, M., Feng, L. X., Guo, X. D., ... & Liu, X. (2024). Carnosol ameliorated cancer cachexia-associated myotube atrophy by targeting P5CS and its downstream pathways. Frontiers in Pharmacology, 14, 1291194. PMID: 38249348 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10799341/ PMC10799341] DOI: 10.3389/fphar.2023.1291194</ref>
	# '''handelin''' <ref>Zhang, H. J., Wang, B. H., Wang, X., Huang, C. P., Xu, S. M., Wang, J. L., ... & Xiang, Y. (2024). Handelin alleviates cachexia‐and aging‐induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation. Journal of Cachexia, Sarcopenia and Muscle, 15(1), 173-188. PMID: 38009816 PMC10834327 DOI: 10.1002/jcsm.13381</ref>		# '''handelin''' <ref>Zhang, H. J., Wang, B. H., Wang, X., Huang, C. P., Xu, S. M., Wang, J. L., ... & Xiang, Y. (2024). Handelin alleviates cachexia‐and aging‐induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation. Journal of Cachexia, Sarcopenia and Muscle, 15(1), 173-188. PMID: 38009816 PMC10834327 DOI: 10.1002/jcsm.13381</ref>

Dmitry Dzhagarov: /* Plant-derived bioactive compounds beneficial in preventing muscle loss and restoring muscle function */

2024-09-01T13:01:58Z

Plant-derived bioactive compounds beneficial in preventing muscle loss and restoring muscle function

← Older revision		Revision as of 13:01, 1 September 2024
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	== Plant-derived bioactive compounds beneficial in preventing muscle loss and restoring muscle function ==		== Plant-derived bioactive compounds beneficial in preventing muscle loss and restoring muscle function ==
	# triptolide <ref>Fang, W. Y., Tseng, Y. T., Lee, T. Y., Fu, Y. C., Chang, W. H., Lo, W. W., ... & Lo, Y. C. (2021). Triptolide prevents LPS‐induced skeletal muscle atrophy via inhibiting NF‐κB/TNF‐α and regulating protein synthesis/degradation pathway. British Journal of Pharmacology, 178(15), 2998-3016. PMID: 33788266 DOI: 10.1111/bph.15472</ref>		# '''triptolide''' <ref>Fang, W. Y., Tseng, Y. T., Lee, T. Y., Fu, Y. C., Chang, W. H., Lo, W. W., ... & Lo, Y. C. (2021). Triptolide prevents LPS‐induced skeletal muscle atrophy via inhibiting NF‐κB/TNF‐α and regulating protein synthesis/degradation pathway. British Journal of Pharmacology, 178(15), 2998-3016. PMID: 33788266 DOI: 10.1111/bph.15472</ref>
	# myricanol <ref>Shen, S., Liao, Q., Lyu, P., Wang, J., & Lin, L. (2024). Myricanol prevents aging‐related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5. MedComm, 5(6), e566. PMID: 38868327 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167181/ PMC11167181] DOI: 10.1002/mco2.566</ref>		# '''myricanol''' <ref>Shen, S., Liao, Q., Lyu, P., Wang, J., & Lin, L. (2024). Myricanol prevents aging‐related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5. MedComm, 5(6), e566. PMID: 38868327 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167181/ PMC11167181] DOI: 10.1002/mco2.566</ref>
	# tomatidine <ref>Dyle, M. C., Ebert, S. M., Cook, D. P., Kunkel, S. D., Fox, D. K., Bongers, K. S., ... & Adams, C. M. (2014). Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy. Journal of Biological Chemistry, 289(21), 14913-14924. PMID: 24719321 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031541/ PMC4031541] DOI: 10.1074/jbc.M114.556241</ref>		# '''tomatidine''' <ref>Dyle, M. C., Ebert, S. M., Cook, D. P., Kunkel, S. D., Fox, D. K., Bongers, K. S., ... & Adams, C. M. (2014). Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy. Journal of Biological Chemistry, 289(21), 14913-14924. PMID: 24719321 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031541/ PMC4031541] DOI: 10.1074/jbc.M114.556241</ref>
	# carnosol <ref>Lu, S., Li, Y., Shen, Q., Zhang, W., Gu, X., Ma, M., ... & Zhang, X. (2021). Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia. Journal of cachexia, sarcopenia and muscle, 12(3), 779-795. </ref> exhibited anticachexia effects mainly by inhibiting TNF-α/NF-κB pathway and decreasing muscle and adipose tissue loss. Carnosol might also ameliorate cancer cachexia-associated myotube atrophy by targeting P5CS (Delta-1-pyrroline-5-carboxylate synthase) and its downstream pathways.<ref>Fang, Q. Y., Wang, Y. P., Zhang, R. Q., Fan, M., Feng, L. X., Guo, X. D., ... & Liu, X. (2024). Carnosol ameliorated cancer cachexia-associated myotube atrophy by targeting P5CS and its downstream pathways. Frontiers in Pharmacology, 14, 1291194. PMID: 38249348 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10799341/ PMC10799341] DOI: 10.3389/fphar.2023.1291194</ref>		# '''carnosol''' <ref>Lu, S., Li, Y., Shen, Q., Zhang, W., Gu, X., Ma, M., ... & Zhang, X. (2021). Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia. Journal of cachexia, sarcopenia and muscle, 12(3), 779-795. </ref> exhibited anticachexia effects mainly by inhibiting TNF-α/NF-κB pathway and decreasing muscle and adipose tissue loss. Carnosol might also ameliorate cancer cachexia-associated myotube atrophy by targeting P5CS (Delta-1-pyrroline-5-carboxylate synthase) and its downstream pathways.<ref>Fang, Q. Y., Wang, Y. P., Zhang, R. Q., Fan, M., Feng, L. X., Guo, X. D., ... & Liu, X. (2024). Carnosol ameliorated cancer cachexia-associated myotube atrophy by targeting P5CS and its downstream pathways. Frontiers in Pharmacology, 14, 1291194. PMID: 38249348 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10799341/ PMC10799341] DOI: 10.3389/fphar.2023.1291194</ref>
	# handelin <ref>Zhang, H. J., Wang, B. H., Wang, X., Huang, C. P., Xu, S. M., Wang, J. L., ... & Xiang, Y. (2024). Handelin alleviates cachexia‐and aging‐induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation. Journal of Cachexia, Sarcopenia and Muscle, 15(1), 173-188. PMID: 38009816 PMC10834327 DOI: 10.1002/jcsm.13381</ref>		# '''handelin''' <ref>Zhang, H. J., Wang, B. H., Wang, X., Huang, C. P., Xu, S. M., Wang, J. L., ... & Xiang, Y. (2024). Handelin alleviates cachexia‐and aging‐induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation. Journal of Cachexia, Sarcopenia and Muscle, 15(1), 173-188. PMID: 38009816 PMC10834327 DOI: 10.1002/jcsm.13381</ref>

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2024-09-01T12:59:25Z

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'''Preventing muscle loss'''

Skeletal muscle atrophy is characterized by weakening, shrinking, and decreasing muscle mass and fiber cross-sectional area at the histological level. It manifests as a reduction in force production, easy fatigue and decreased exercise capability, along with a lower quality of life.
'''Exercise''' is widely acknowledged as '''the most effective therapy for skeletal muscle atrophy'''; unfortunately, it is not applicable for all patients. Several active substances for skeletal muscle atrophy have been discovered and evaluated in clinical trials, however, they have not been marketed to date.

== Plant-derived bioactive compounds beneficial in preventing muscle loss and restoring muscle function ==
# triptolide <ref>Fang, W. Y., Tseng, Y. T., Lee, T. Y., Fu, Y. C., Chang, W. H., Lo, W. W., ... & Lo, Y. C. (2021). Triptolide prevents LPS‐induced skeletal muscle atrophy via inhibiting NF‐κB/TNF‐α and regulating protein synthesis/degradation pathway. British Journal of Pharmacology, 178(15), 2998-3016. PMID: 33788266 DOI: 10.1111/bph.15472</ref>
# myricanol <ref>Shen, S., Liao, Q., Lyu, P., Wang, J., & Lin, L. (2024). Myricanol prevents aging‐related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5. MedComm, 5(6), e566. PMID: 38868327 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167181/ PMC11167181] DOI: 10.1002/mco2.566</ref>
# tomatidine <ref>Dyle, M. C., Ebert, S. M., Cook, D. P., Kunkel, S. D., Fox, D. K., Bongers, K. S., ... & Adams, C. M. (2014). Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy. Journal of Biological Chemistry, 289(21), 14913-14924. PMID: 24719321 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031541/ PMC4031541] DOI: 10.1074/jbc.M114.556241</ref>
# carnosol <ref>Lu, S., Li, Y., Shen, Q., Zhang, W., Gu, X., Ma, M., ... & Zhang, X. (2021). Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia. Journal of cachexia, sarcopenia and muscle, 12(3), 779-795. </ref> exhibited anticachexia effects mainly by inhibiting TNF-α/NF-κB pathway and decreasing muscle and adipose tissue loss. Carnosol might also ameliorate cancer cachexia-associated myotube atrophy by targeting P5CS (Delta-1-pyrroline-5-carboxylate synthase) and its downstream pathways.<ref>Fang, Q. Y., Wang, Y. P., Zhang, R. Q., Fan, M., Feng, L. X., Guo, X. D., ... & Liu, X. (2024). Carnosol ameliorated cancer cachexia-associated myotube atrophy by targeting P5CS and its downstream pathways. Frontiers in Pharmacology, 14, 1291194. PMID: 38249348 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10799341/ PMC10799341] DOI: 10.3389/fphar.2023.1291194</ref>
# handelin <ref>Zhang, H. J., Wang, B. H., Wang, X., Huang, C. P., Xu, S. M., Wang, J. L., ... & Xiang, Y. (2024). Handelin alleviates cachexia‐and aging‐induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation. Journal of Cachexia, Sarcopenia and Muscle, 15(1), 173-188. PMID: 38009816 PMC10834327 DOI: 10.1002/jcsm.13381</ref>