https://en.longevitywiki.org/wiki/Proteolysis/history?feed=atom
Proteolysis - Revision history
2026-04-04T13:49:28Z
Revision history for this page on the wiki
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https://en.longevitywiki.org/index.php?title=Proteolysis&diff=2354&oldid=prev
Andrea: category change
2022-12-27T13:01:05Z
<p>category change</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:01, 27 December 2022</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Proteolysis can serve a variety of biological functions, including protein digestion, apoptosis, regulating cell cycle, cellular homeostasis and preventing accumulation of aggregated or misfolded proteins.<ref>Thomas E Creighton (1993). "Chapter 10 - Degradation". ''Proteins: Structures and Molecular Properties'' (2nd ed.). W H Freeman and Company. pp. 463–473. [[ISBN (identifier)|ISBN]] [[Special:BookSources/978-0-7167-2317-2|<bdi>978-0-7167-2317-2</bdi>]].</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Proteolysis can serve a variety of biological functions, including protein digestion, apoptosis, regulating cell cycle, cellular homeostasis and preventing accumulation of aggregated or misfolded proteins.<ref>Thomas E Creighton (1993). "Chapter 10 - Degradation". ''Proteins: Structures and Molecular Properties'' (2nd ed.). W H Freeman and Company. pp. 463–473. [[ISBN (identifier)|ISBN]] [[Special:BookSources/978-0-7167-2317-2|<bdi>978-0-7167-2317-2</bdi>]].</ref></div></td></tr>
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Andrea
https://en.longevitywiki.org/index.php?title=Proteolysis&diff=2197&oldid=prev
Andrea: glossary entry
2022-12-01T15:04:06Z
<p>glossary entry</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:04, 1 December 2022</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">{{Draft-article}}</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Proteolysis is the hydrolysis of peptide bonds, which leads to proteins breaking down into shorter peptide chains or into their amino acid constituents. Protein hydrolysis is usually catalysed by enzymes called proteostases, but can also occur due to chemicals such as certain types of venom.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Proteolysis <del style="font-weight: bold; text-decoration: none;">is the hydrolysis </del>of <del style="font-weight: bold; text-decoration: none;">peptide bonds</del>, <del style="font-weight: bold; text-decoration: none;">which leads to proteins breaking down into shorter peptide chains or into their amino acid constituents. The ubiquitin/proteasome system (UPS) regulates the rate of synthesis </del>and <del style="font-weight: bold; text-decoration: none;">degradation (turnover) </del>of misfolded <del style="font-weight: bold; text-decoration: none;">or damaged </del>proteins<del style="font-weight: bold; text-decoration: none;">, which helps maintain cellular and protein homeostasis (commonly referred to as proteostasis). Loss of proteostasis is considered to be a [[Hallmarks of aging|hallmark of aging]], and several ubiquitin-dependent protein degradation pathways have been shown to regulate lifespan</del>.<ref><del style="font-weight: bold; text-decoration: none;">López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. </del>(<del style="font-weight: bold; text-decoration: none;">2013</del>). <del style="font-weight: bold; text-decoration: none;">The hallmarks of aging</del>. ''<del style="font-weight: bold; text-decoration: none;">Cell'', ''153</del>''(<del style="font-weight: bold; text-decoration: none;">6</del>)<del style="font-weight: bold; text-decoration: none;">, 1194-1217</del>.<del style="font-weight: bold; text-decoration: none;"></ref><ref>Hoppe T. Life </del>and <del style="font-weight: bold; text-decoration: none;">destruction: ubiquitin-mediated proteolysis in aging and longevity</del>. <del style="font-weight: bold; text-decoration: none;">F1000 Biol Rep</del>. <del style="font-weight: bold; text-decoration: none;">2010 Nov 11;2:79</del>. <del style="font-weight: bold; text-decoration: none;">doi</del>: <del style="font-weight: bold; text-decoration: none;">10.3410</del>/<del style="font-weight: bold; text-decoration: none;">B2</del>-<del style="font-weight: bold; text-decoration: none;">79. PMID: 21151840; PMCID: PMC2998811</del>.</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Proteolysis <ins style="font-weight: bold; text-decoration: none;">can serve a variety </ins>of <ins style="font-weight: bold; text-decoration: none;">biological functions, including protein digestion, apoptosis, regulating cell cycle</ins>, <ins style="font-weight: bold; text-decoration: none;">cellular homeostasis </ins>and <ins style="font-weight: bold; text-decoration: none;">preventing accumulation </ins>of <ins style="font-weight: bold; text-decoration: none;">aggregated or </ins>misfolded proteins.<ref><ins style="font-weight: bold; text-decoration: none;">Thomas E Creighton </ins>(<ins style="font-weight: bold; text-decoration: none;">1993</ins>). <ins style="font-weight: bold; text-decoration: none;">"Chapter 10 - Degradation"</ins>. ''<ins style="font-weight: bold; text-decoration: none;">Proteins: Structures and Molecular Properties</ins>'' (<ins style="font-weight: bold; text-decoration: none;">2nd ed.</ins>). <ins style="font-weight: bold; text-decoration: none;">W H Freeman </ins>and <ins style="font-weight: bold; text-decoration: none;">Company</ins>. <ins style="font-weight: bold; text-decoration: none;">pp</ins>. <ins style="font-weight: bold; text-decoration: none;">463–473</ins>. <ins style="font-weight: bold; text-decoration: none;">[[ISBN (identifier)|ISBN]] [[Special</ins>:<ins style="font-weight: bold; text-decoration: none;">BookSources</ins>/<ins style="font-weight: bold; text-decoration: none;">978-0-7167-2317</ins>-<ins style="font-weight: bold; text-decoration: none;">2|<bdi>978-0-7167-2317-2</bdi>]]</ins>.</ref></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Category:Drafts]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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Andrea
https://en.longevitywiki.org/index.php?title=Proteolysis&diff=2172&oldid=prev
Andrea: intro and link to main list
2022-11-15T13:17:41Z
<p>intro and link to main list</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:17, 15 November 2022</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Proteolysis <ins style="font-weight: bold; text-decoration: none;">is the hydrolysis of peptide bonds, which leads to proteins breaking down into shorter peptide chains or into their amino acid constituents. The ubiquitin/proteasome system (UPS) regulates the rate of synthesis and degradation (turnover) of misfolded or damaged proteins, which helps maintain cellular and protein homeostasis (commonly referred to as proteostasis). Loss of proteostasis is considered to be a [[Hallmarks of aging|hallmark of aging]], and several ubiquitin-dependent protein degradation pathways have been shown to regulate lifespan.<ref>López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. ''Cell'', ''153''(6), 1194-1217.</ref><ref>Hoppe T. Life and destruction: ubiquitin-mediated proteolysis in aging and longevity. F1000 Biol Rep. 2010 Nov 11;2:79. doi: 10.3410/B2-79. PMID: 21151840; PMCID: PMC2998811.</ref></ins></div></td></tr>
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Andrea
https://en.longevitywiki.org/index.php?title=Proteolysis&diff=2165&oldid=prev
Andrea: generated entry
2022-11-12T19:20:33Z
<p>generated entry</p>
<p><b>New page</b></p><div><br />
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Proteolysis<br />
[[Category:Drafts]]</div>
Andrea