Rejuvant - Revision history

Dmitry Dzhagarov at 15:07, 7 February 2024

2024-02-07T15:07:35Z

← Older revision		Revision as of 15:07, 7 February 2024
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	'''Rejuvant®''', an alpha-ketoglutarate based formulation that was found to extend lifespan and delay the onset of age-associated decline in experimental models such as nematodes, fruit flies, yeasts, and mice.<ref>Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer III, F. R., Kennedy, B. K., & Budovskaya, Y. V. (2021). Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (albany NY), 13(22), 24485. PMID: 34847066 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660611/ PMC8660611] DOI: 10.18632/aging.203736</ref><ref>Naeini, S. H., Mavaddatiyan, L., Kalkhoran, Z. R., Taherkhani, S., & Talkhabi, M. (2023). Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives. Experimental Gerontology, 175, 112154. PMID: 36934991 [https://doi.org/10.1016/j.exger.2023.112154 DOI: 10.1016/j.exger.2023.112154]</ref><ref>Shahmirzadi, A. A., Edgar, D., Liao, C. Y., Hsu, Y. M., Lucanic, M., Shahmirzadi, A. A., ... & Lithgow, G. J. (2020). Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell metabolism, 32(3), 447-456. PMID: 32877690 PMCID: PMC8508957 DOI: 10.1016/j.cmet.2020.08.004</ref>		'''Rejuvant®''', an alpha-ketoglutarate based formulation that was found to extend lifespan and delay the onset of age-associated decline in experimental models such as nematodes, fruit flies, yeasts, and mice.<ref name="Rejuv" >Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer III, F. R., Kennedy, B. K., & Budovskaya, Y. V. (2021). Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (albany NY), 13(22), 24485. PMID: 34847066 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660611/ PMC8660611] DOI: 10.18632/aging.203736</ref><ref>Naeini, S. H., Mavaddatiyan, L., Kalkhoran, Z. R., Taherkhani, S., & Talkhabi, M. (2023). Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives. Experimental Gerontology, 175, 112154. PMID: 36934991 [https://doi.org/10.1016/j.exger.2023.112154 DOI: 10.1016/j.exger.2023.112154]</ref><ref>Shahmirzadi, A. A., Edgar, D., Liao, C. Y., Hsu, Y. M., Lucanic, M., Shahmirzadi, A. A., ... & Lithgow, G. J. (2020). Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell metabolism, 32(3), 447-456. PMID: 32877690 PMCID: PMC8508957 DOI: 10.1016/j.cmet.2020.08.004</ref>
	Alpha-ketoglutarate (AKG) is involved in pleiotropic metabolic and regulatory pathways in the cell, including energy production, biosynthesis of certain amino acids, collagen biosynthesis, epigenetic regulation of gene expression, regulation of redox homeostasis, and detoxification of hazardous substances.<ref>Zdzisińska, B., Żurek, A., & Kandefer-Szerszeń, M. (2017). Alpha-ketoglutarate as a molecule with pleiotropic activity: well-known and novel possibilities of therapeutic use. Archivum immunologiae et therapiae experimentalis, 65, 21-36. PMID: 27326424 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5274648/ PMC5274648] DOI: 10.1007/s00005-016-0406-x</ref><ref>Bayliak, M. M., & Lushchak, V. I. (2021). Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent. Ageing Research Reviews, 66, 101237. PMID: 33340716 DOI: 10.1016/j.arr.2020.101237</ref>		Alpha-ketoglutarate (AKG) is involved in pleiotropic metabolic and regulatory pathways in the cell, including energy production, biosynthesis of certain amino acids, collagen biosynthesis, epigenetic regulation of gene expression, regulation of redox homeostasis, and detoxification of hazardous substances.<ref>Zdzisińska, B., Żurek, A., & Kandefer-Szerszeń, M. (2017). Alpha-ketoglutarate as a molecule with pleiotropic activity: well-known and novel possibilities of therapeutic use. Archivum immunologiae et therapiae experimentalis, 65, 21-36. PMID: 27326424 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5274648/ PMC5274648] DOI: 10.1007/s00005-016-0406-x</ref><ref>Bayliak, M. M., & Lushchak, V. I. (2021). Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent. Ageing Research Reviews, 66, 101237. PMID: 33340716 DOI: 10.1016/j.arr.2020.101237</ref>

			The formulation of the Rejuvant® supplement is itself different for males and females. More specifically, in addition to CaAKG (Calcium Alpha-Ketoglutarate Monohydrate (LifeAKG™) 1000 mg + 190 mg Calcium), vitamin A (as retinyl palmitate 900 mcg) and vitamin D (25 mcg) are added to the [https://www.amazon.com/Rejuvant-LifeTabs-Male-Formula/dp/B09M986WZT men’s] or [https://www.amazon.com/Rejuvant-LifeTabs-Female-Formula/dp/B09M99BR8R women’s] commercial formulation, respectively.<ref name="Rejuv" />

	== References ==		== References ==

Dmitry Dzhagarov: /* References */

2024-02-07T08:17:23Z

References

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Dmitry Dzhagarov: Created page with "'''Rejuvant®''', an alpha-ketoglutarate based formulation that was found to extend lifespan and delay the onset of age-associated decline in experimental models such as nematodes, fruit flies, yeasts, and mice.Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer III, F. R., Kennedy, B. K., & Budovskaya, Y. V. (2021). Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction..."

2024-02-07T08:11:35Z

Created page with "'''Rejuvant®''', an alpha-ketoglutarate based formulation that was found to extend lifespan and delay the onset of age-associated decline in experimental models such as nematodes, fruit flies, yeasts, and mice.<ref>Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer III, F. R., Kennedy, B. K., & Budovskaya, Y. V. (2021). Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction..."

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'''Rejuvant®''', an alpha-ketoglutarate based formulation that was found to extend lifespan and delay the onset of age-associated decline in experimental models such as nematodes, fruit flies, yeasts, and mice.<ref>Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer III, F. R., Kennedy, B. K., & Budovskaya, Y. V. (2021). Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (albany NY), 13(22), 24485. PMID: 34847066 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660611/ PMC8660611] DOI: 10.18632/aging.203736</ref><ref>Naeini, S. H., Mavaddatiyan, L., Kalkhoran, Z. R., Taherkhani, S., & Talkhabi, M. (2023). Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives. Experimental Gerontology, 175, 112154. PMID: 36934991 [https://doi.org/10.1016/j.exger.2023.112154 DOI: 10.1016/j.exger.2023.112154]</ref><ref>Shahmirzadi, A. A., Edgar, D., Liao, C. Y., Hsu, Y. M., Lucanic, M., Shahmirzadi, A. A., ... & Lithgow, G. J. (2020). Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell metabolism, 32(3), 447-456. PMID: 32877690 PMCID: PMC8508957 DOI: 10.1016/j.cmet.2020.08.004</ref>
Alpha-ketoglutarate (AKG) is involved in pleiotropic metabolic and regulatory pathways in the cell, including energy production, biosynthesis of certain amino acids, collagen biosynthesis, epigenetic regulation of gene expression, regulation of redox homeostasis, and detoxification of hazardous substances.<ref>Zdzisińska, B., Żurek, A., & Kandefer-Szerszeń, M. (2017). Alpha-ketoglutarate as a molecule with pleiotropic activity: well-known and novel possibilities of therapeutic use. Archivum immunologiae et therapiae experimentalis, 65, 21-36. PMID: 27326424 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5274648/ PMC5274648] DOI: 10.1007/s00005-016-0406-x</ref><ref>Bayliak, M. M., & Lushchak, V. I. (2021). Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent. Ageing Research Reviews, 66, 101237. PMID: 33340716 DOI: 10.1016/j.arr.2020.101237</ref>

== References ==
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