Dmitry Dzhagarov: Created page with "'''JNK (c-Jun N-terminal kinase)''' is a crucial signaling pathway that plays a significant role in normal physiological processes. The JNK signaling pathway exhibits a dual nature during the aging process. For instance, when JNK is activated in the brain, it leads to a prolonged lifespan, whereas moderate activation of JNK in midgut intestinal stem cells (ISCs) and enteroblasts significantly shortens lifespan.Gan, T., Fan, L., Zhao, L., Misra, M., Liu, M., Zhang, M..."

2024-09-21T10:34:56Z

Created page with "'''JNK (c-Jun N-terminal kinase)''' is a crucial signaling pathway that plays a significant role in normal physiological processes. The JNK signaling pathway exhibits a dual nature during the aging process. For instance, when JNK is activated in the brain, it leads to a prolonged lifespan, whereas moderate activation of JNK in midgut intestinal stem cells (ISCs) and enteroblasts significantly shortens lifespan.<ref>Gan, T., Fan, L., Zhao, L., Misra, M., Liu, M., Zhang, M..."

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'''JNK (c-Jun N-terminal kinase)''' is a crucial signaling pathway that plays a significant role in normal physiological processes. The JNK signaling pathway exhibits a dual nature during the aging process. For instance, when JNK is activated in the brain, it leads to a prolonged lifespan, whereas moderate activation of JNK in midgut intestinal stem cells (ISCs) and enteroblasts significantly shortens lifespan.<ref>Gan, T., Fan, L., Zhao, L., Misra, M., Liu, M., Zhang, M., & Su, Y. (2021). JNK signaling in Drosophila aging and longevity. International Journal of Molecular Sciences, 22(17), 9649. PMID: 34502551 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431792 PMC8431792] DOI: 10.3390/ijms22179649</ref>
JNK demonstrates the ability to diminish telomerase reverse transcriptase activity, elevate β-galactosidase activity, and induce telomere shortening, thereby contributing to immune system aging. <ref name="JNK" >Li, Y., You, L., Nepovimova, E., Adam, V., Heger, Z., Jomova, K., ... & Kuca, K. (2024). c-Jun N-terminal kinase signaling in aging. Frontiers in Aging Neuroscience, 16, 1453710. PMID: 39267721 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11390425/ PMC11390425] [https://doi.org/10.3389/fnagi.2024.1453710 DOI: 10.3389/fnagi.2024.1453710]</ref>

Studies in mice suggest that mammalian JNK exerts widespread and context-dependent effects in models of aging and diseases.<ref name="JNK" />

== JNK inhibitors ==
JNK inhibitors hold the potential to delay aging and treat age-associated conditions. Notable examples of JNK inhibitors include '''SP600125, CC-930, CC-401, CC-90001, and CEP-1347'''.<ref name="JNK" />

== References ==
<references />

[[Category:Longevity genes]]
[[Category:Main list]]
[[Category:Aging pathways and hallmarks]]
[[Category:Drafts]]
[[Category:Stub]]

Role of JNK in aging - Revision history