TERT activator compound (TAC) - Revision history

Dmitry Dzhagarov at 14:55, 26 July 2024

2024-07-26T14:55:07Z

← Older revision		Revision as of 14:55, 26 July 2024
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	\| '''Molecular Weight''': 331.762		\| '''Molecular Weight''': 331.762
	\|}		\|}
	'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref name="TAC">Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref><ref>[https://www.medkoo.com/products/58532 MedKoo Cat#: 556370] TERT activator compound (TAC) </ref>		'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref name="TAC">Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref><ref>Marchal, I. (2024). Counteracting tissue aging through TERT activation. Nat Biotechnol 42, 1027 https://doi.org/10.1038/s41587-024-02327-8</ref><ref>[https://www.medkoo.com/products/58532 MedKoo Cat#: 556370] TERT activator compound (TAC) </ref>

	Besides telomere extension, TERT exhibits other non-telomeric activities such as cell cycle regulation, modulation of cellular signaling and gene expression, augmentation of proliferative lifespan as well as the antioxidant defense and DNA damage responses.<ref>Marinaccio, J., Micheli, E., Udroiu, I., Di Nottia, M., Carrozzo, R., Baranzini, N., ... & Sgura, A. (2023). TERT extra-telomeric roles: antioxidant activity and mitochondrial protection. International Journal of Molecular Sciences, 24(5), 4450. PMID: 36901881 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002448/ PMC10002448] DOI: 10.3390/ijms24054450</ref> Moreover, TERT participates in the mechanisms of cell competition.<ref>Hasegawa, K., Zhao, Y., Garbuzov, A., Corces, M. R., Neuhöfer, P., Gillespie, V. M., ... & Artandi, S. E. (2024). Clonal inactivation of TERT impairs stem cell competition. Nature, 1-8. PMID: 39020172 [https://doi.org/10.1038/s41586-024-07700-w DOI: 10.1038/s41586-024-07700-w]</ref>		Besides telomere extension, TERT exhibits other non-telomeric activities such as cell cycle regulation, modulation of cellular signaling and gene expression, augmentation of proliferative lifespan as well as the antioxidant defense and DNA damage responses.<ref>Marinaccio, J., Micheli, E., Udroiu, I., Di Nottia, M., Carrozzo, R., Baranzini, N., ... & Sgura, A. (2023). TERT extra-telomeric roles: antioxidant activity and mitochondrial protection. International Journal of Molecular Sciences, 24(5), 4450. PMID: 36901881 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002448/ PMC10002448] DOI: 10.3390/ijms24054450</ref> Moreover, TERT participates in the mechanisms of cell competition.<ref>Hasegawa, K., Zhao, Y., Garbuzov, A., Corces, M. R., Neuhöfer, P., Gillespie, V. M., ... & Artandi, S. E. (2024). Clonal inactivation of TERT impairs stem cell competition. Nature, 1-8. PMID: 39020172 [https://doi.org/10.1038/s41586-024-07700-w DOI: 10.1038/s41586-024-07700-w]</ref>

Dmitry Dzhagarov at 14:22, 26 July 2024

2024-07-26T14:22:19Z

← Older revision		Revision as of 14:22, 26 July 2024
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	In experiments on aged mice, it was shown that TAC reaches numerous tissues and organs and reduces the signs of aging in them. By acting on the body's tissues, it significantly reduced age-related inflammation in tissues by reducing cellular senescence and inflammatory cytokines, improved neuromuscular function, coordination, grip strength and speed, stimulating neurogenesis and reversing sarcopenia.<ref name="TAC" /> In this case, the drug is eliminated from the body in about three hours. This was enough to improve numerous signs of aging. Chronic administration of TAC had a noticeable effect on the brain health and cognitive performance of mice without obvious toxicity or increased cancer risk.<ref name="TAC" /><ref>[https://www.mdanderson.org/newsroom/activating-molecular-target-reverses-multiple-hallmarks-of-aging.h00-159698334.html Activating molecular target reverses multiple hallmarks of aging]. MD Anderson Cancer Center.The University of Texas.</ref><ref>Walters, H. Pharmacological TERT activation attenuates phenotypes of natural aging. Nature aging. PMID: 38977936 [https://doi.org/10.1038/s43587-024-00673-5 DOI: 10.1038/s43587-024-00673-5]</ref>		In experiments on aged mice, it was shown that TAC reaches numerous tissues and organs and reduces the signs of aging in them. By acting on the body's tissues, it significantly reduced age-related inflammation in tissues by reducing cellular senescence and inflammatory cytokines, improved neuromuscular function, coordination, grip strength and speed, stimulating neurogenesis and reversing sarcopenia.<ref name="TAC" /> In this case, the drug is eliminated from the body in about three hours. This was enough to improve numerous signs of aging. Chronic administration of TAC had a noticeable effect on the brain health and cognitive performance of mice without obvious toxicity or increased cancer risk.<ref name="TAC" /><ref>[https://www.mdanderson.org/newsroom/activating-molecular-target-reverses-multiple-hallmarks-of-aging.h00-159698334.html Activating molecular target reverses multiple hallmarks of aging]. MD Anderson Cancer Center.The University of Texas.</ref><ref>Walters, H. Pharmacological TERT activation attenuates phenotypes of natural aging. Nature aging. PMID: 38977936 [https://doi.org/10.1038/s43587-024-00673-5 DOI: 10.1038/s43587-024-00673-5]</ref>

			An enzyme called telomerase and related genes might be powerful targets for the treatment of age-related diseases such as cardiovascular, cognitive, neurodegenerative diseases, and cancer.<ref>Aydin, Y., Orta-Yilmaz, B. (2023). The Role of Telomerase Activators in Antiaging Strategies and their Clinical Potential. In: Rizvi, S.I. (eds) Emerging Anti-Aging Strategies. Springer, Singapore. https://doi.org/10.1007/978-981-19-7443-4_12 </ref>

	== References ==		== References ==

Dmitry Dzhagarov at 14:44, 20 July 2024

2024-07-20T14:44:51Z

← Older revision		Revision as of 14:44, 20 July 2024
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	'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref name="TAC">Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref><ref>[https://www.medkoo.com/products/58532 MedKoo Cat#: 556370] TERT activator compound (TAC) </ref>		'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref name="TAC">Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref><ref>[https://www.medkoo.com/products/58532 MedKoo Cat#: 556370] TERT activator compound (TAC) </ref>

	Besides telomere extension, TERT exhibits other non-telomeric activities such as cell cycle regulation, modulation of cellular signaling and gene expression, augmentation of proliferative lifespan as well as the antioxidant defense and DNA damage responses.<ref>Marinaccio, J., Micheli, E., Udroiu, I., Di Nottia, M., Carrozzo, R., Baranzini, N., ... & Sgura, A. (2023). TERT extra-telomeric roles: antioxidant activity and mitochondrial protection. International Journal of Molecular Sciences, 24(5), 4450. {{PMID\|36901881}} [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002448/ PMC10002448] DOI: 10.3390/ijms24054450</ref> Moreover, TERT participates in the mechanisms of cell competition.<ref>Hasegawa, K., Zhao, Y., Garbuzov, A., Corces, M. R., Neuhöfer, P., Gillespie, V. M., ... & Artandi, S. E. (2024). Clonal inactivation of TERT impairs stem cell competition. Nature, 1-8. PMID: 39020172 [https://doi.org/10.1038/s41586-024-07700-w DOI: 10.1038/s41586-024-07700-w]</ref>		Besides telomere extension, TERT exhibits other non-telomeric activities such as cell cycle regulation, modulation of cellular signaling and gene expression, augmentation of proliferative lifespan as well as the antioxidant defense and DNA damage responses.<ref>Marinaccio, J., Micheli, E., Udroiu, I., Di Nottia, M., Carrozzo, R., Baranzini, N., ... & Sgura, A. (2023). TERT extra-telomeric roles: antioxidant activity and mitochondrial protection. International Journal of Molecular Sciences, 24(5), 4450. PMID: 36901881 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002448/ PMC10002448] DOI: 10.3390/ijms24054450</ref> Moreover, TERT participates in the mechanisms of cell competition.<ref>Hasegawa, K., Zhao, Y., Garbuzov, A., Corces, M. R., Neuhöfer, P., Gillespie, V. M., ... & Artandi, S. E. (2024). Clonal inactivation of TERT impairs stem cell competition. Nature, 1-8. PMID: 39020172 [https://doi.org/10.1038/s41586-024-07700-w DOI: 10.1038/s41586-024-07700-w]</ref>

	In experiments on aged mice, it was shown that TAC reaches numerous tissues and organs and reduces the signs of aging in them. By acting on the body's tissues, it significantly reduced age-related inflammation in tissues by reducing cellular senescence and inflammatory cytokines, improved neuromuscular function, coordination, grip strength and speed, stimulating neurogenesis and reversing sarcopenia.<ref name="TAC" /> In this case, the drug is eliminated from the body in about three hours. This was enough to improve numerous signs of aging. Chronic administration of TAC had a noticeable effect on the brain health and cognitive performance of mice without obvious toxicity or increased cancer risk.<ref name="TAC" /><ref>[https://www.mdanderson.org/newsroom/activating-molecular-target-reverses-multiple-hallmarks-of-aging.h00-159698334.html Activating molecular target reverses multiple hallmarks of aging]. MD Anderson Cancer Center.The University of Texas.</ref><ref>Walters, H. Pharmacological TERT activation attenuates phenotypes of natural aging. Nature aging. PMID: 38977936 [https://doi.org/10.1038/s43587-024-00673-5 DOI: 10.1038/s43587-024-00673-5]</ref>		In experiments on aged mice, it was shown that TAC reaches numerous tissues and organs and reduces the signs of aging in them. By acting on the body's tissues, it significantly reduced age-related inflammation in tissues by reducing cellular senescence and inflammatory cytokines, improved neuromuscular function, coordination, grip strength and speed, stimulating neurogenesis and reversing sarcopenia.<ref name="TAC" /> In this case, the drug is eliminated from the body in about three hours. This was enough to improve numerous signs of aging. Chronic administration of TAC had a noticeable effect on the brain health and cognitive performance of mice without obvious toxicity or increased cancer risk.<ref name="TAC" /><ref>[https://www.mdanderson.org/newsroom/activating-molecular-target-reverses-multiple-hallmarks-of-aging.h00-159698334.html Activating molecular target reverses multiple hallmarks of aging]. MD Anderson Cancer Center.The University of Texas.</ref><ref>Walters, H. Pharmacological TERT activation attenuates phenotypes of natural aging. Nature aging. PMID: 38977936 [https://doi.org/10.1038/s43587-024-00673-5 DOI: 10.1038/s43587-024-00673-5]</ref>

Dmitry Dzhagarov at 14:41, 20 July 2024

2024-07-20T14:41:25Z

← Older revision		Revision as of 14:41, 20 July 2024
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	'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref name="TAC">Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref><ref>[https://www.medkoo.com/products/58532 MedKoo Cat#: 556370] TERT activator compound (TAC) </ref>		'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref name="TAC">Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref><ref>[https://www.medkoo.com/products/58532 MedKoo Cat#: 556370] TERT activator compound (TAC) </ref>

			Besides telomere extension, TERT exhibits other non-telomeric activities such as cell cycle regulation, modulation of cellular signaling and gene expression, augmentation of proliferative lifespan as well as the antioxidant defense and DNA damage responses.<ref>Marinaccio, J., Micheli, E., Udroiu, I., Di Nottia, M., Carrozzo, R., Baranzini, N., ... & Sgura, A. (2023). TERT extra-telomeric roles: antioxidant activity and mitochondrial protection. International Journal of Molecular Sciences, 24(5), 4450. {{PMID\|36901881}} [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002448/ PMC10002448] DOI: 10.3390/ijms24054450</ref> Moreover, TERT participates in the mechanisms of cell competition.<ref>Hasegawa, K., Zhao, Y., Garbuzov, A., Corces, M. R., Neuhöfer, P., Gillespie, V. M., ... & Artandi, S. E. (2024). Clonal inactivation of TERT impairs stem cell competition. Nature, 1-8. PMID: 39020172 [https://doi.org/10.1038/s41586-024-07700-w DOI: 10.1038/s41586-024-07700-w]</ref>

	In experiments on aged mice, it was shown that TAC reaches numerous tissues and organs and reduces the signs of aging in them. By acting on the body's tissues, it significantly reduced age-related inflammation in tissues by reducing cellular senescence and inflammatory cytokines, improved neuromuscular function, coordination, grip strength and speed, stimulating neurogenesis and reversing sarcopenia.<ref name="TAC" /> In this case, the drug is eliminated from the body in about three hours. This was enough to improve numerous signs of aging. Chronic administration of TAC had a noticeable effect on the brain health and cognitive performance of mice without obvious toxicity or increased cancer risk.<ref name="TAC" /><ref>[https://www.mdanderson.org/newsroom/activating-molecular-target-reverses-multiple-hallmarks-of-aging.h00-159698334.html Activating molecular target reverses multiple hallmarks of aging]. MD Anderson Cancer Center.The University of Texas.</ref><ref>Walters, H. Pharmacological TERT activation attenuates phenotypes of natural aging. Nature aging. PMID: 38977936 [https://doi.org/10.1038/s43587-024-00673-5 DOI: 10.1038/s43587-024-00673-5]</ref>		In experiments on aged mice, it was shown that TAC reaches numerous tissues and organs and reduces the signs of aging in them. By acting on the body's tissues, it significantly reduced age-related inflammation in tissues by reducing cellular senescence and inflammatory cytokines, improved neuromuscular function, coordination, grip strength and speed, stimulating neurogenesis and reversing sarcopenia.<ref name="TAC" /> In this case, the drug is eliminated from the body in about three hours. This was enough to improve numerous signs of aging. Chronic administration of TAC had a noticeable effect on the brain health and cognitive performance of mice without obvious toxicity or increased cancer risk.<ref name="TAC" /><ref>[https://www.mdanderson.org/newsroom/activating-molecular-target-reverses-multiple-hallmarks-of-aging.h00-159698334.html Activating molecular target reverses multiple hallmarks of aging]. MD Anderson Cancer Center.The University of Texas.</ref><ref>Walters, H. Pharmacological TERT activation attenuates phenotypes of natural aging. Nature aging. PMID: 38977936 [https://doi.org/10.1038/s43587-024-00673-5 DOI: 10.1038/s43587-024-00673-5]</ref>

			== References ==
			<references />

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Dmitry Dzhagarov at 14:08, 20 July 2024

2024-07-20T14:08:06Z

← Older revision		Revision as of 14:08, 20 July 2024
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	'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref name="TAC">Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref><ref>[https://www.medkoo.com/products/58532 MedKoo Cat#: 556370] TERT activator compound (TAC) </ref>		'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref name="TAC">Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref><ref>[https://www.medkoo.com/products/58532 MedKoo Cat#: 556370] TERT activator compound (TAC) </ref>
	In experiments on aged mice, it was shown that TAC reaches numerous tissues and organs and reduces the signs of aging in them. By acting on the body's tissues, it significantly reduced age-related inflammation in tissues by reducing cellular senescence and inflammatory cytokines, improved neuromuscular function, coordination, grip strength and speed, stimulating neurogenesis and reversing sarcopenia.<ref name="TAC" /> In this case, the drug is eliminated from the body in about three hours. This was enough to improve numerous signs of aging. Chronic administration of TAC had a noticeable effect on the brain health and cognitive performance of mice without obvious toxicity or increased cancer risk.<ref name="TAC" /><ref>[https://www.mdanderson.org/newsroom/activating-molecular-target-reverses-multiple-hallmarks-of-aging.h00-159698334.html Activating molecular target reverses multiple hallmarks of aging]. MD Anderson Cancer Center.The University of Texas.</ref>		In experiments on aged mice, it was shown that TAC reaches numerous tissues and organs and reduces the signs of aging in them. By acting on the body's tissues, it significantly reduced age-related inflammation in tissues by reducing cellular senescence and inflammatory cytokines, improved neuromuscular function, coordination, grip strength and speed, stimulating neurogenesis and reversing sarcopenia.<ref name="TAC" /> In this case, the drug is eliminated from the body in about three hours. This was enough to improve numerous signs of aging. Chronic administration of TAC had a noticeable effect on the brain health and cognitive performance of mice without obvious toxicity or increased cancer risk.<ref name="TAC" /><ref>[https://www.mdanderson.org/newsroom/activating-molecular-target-reverses-multiple-hallmarks-of-aging.h00-159698334.html Activating molecular target reverses multiple hallmarks of aging]. MD Anderson Cancer Center.The University of Texas.</ref><ref>Walters, H. Pharmacological TERT activation attenuates phenotypes of natural aging. Nature aging. PMID: 38977936 [https://doi.org/10.1038/s43587-024-00673-5 DOI: 10.1038/s43587-024-00673-5]</ref>

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Dmitry Dzhagarov at 13:54, 20 July 2024

2024-07-20T13:54:16Z

← Older revision		Revision as of 13:54, 20 July 2024
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	\| '''Molecular Weight''': 331.762		\| '''Molecular Weight''': 331.762
	\|}		\|}
	'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref>Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref><ref>[https://www.medkoo.com/products/58532 MedKoo Cat#: 556370] TERT activator compound (TAC) </ref>		'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref name="TAC">Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref><ref>[https://www.medkoo.com/products/58532 MedKoo Cat#: 556370] TERT activator compound (TAC) </ref>
			In experiments on aged mice, it was shown that TAC reaches numerous tissues and organs and reduces the signs of aging in them. By acting on the body's tissues, it significantly reduced age-related inflammation in tissues by reducing cellular senescence and inflammatory cytokines, improved neuromuscular function, coordination, grip strength and speed, stimulating neurogenesis and reversing sarcopenia.<ref name="TAC" /> In this case, the drug is eliminated from the body in about three hours. This was enough to improve numerous signs of aging. Chronic administration of TAC had a noticeable effect on the brain health and cognitive performance of mice without obvious toxicity or increased cancer risk.<ref name="TAC" /><ref>[https://www.mdanderson.org/newsroom/activating-molecular-target-reverses-multiple-hallmarks-of-aging.h00-159698334.html Activating molecular target reverses multiple hallmarks of aging]. MD Anderson Cancer Center.The University of Texas.</ref>

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Dmitry Dzhagarov at 17:13, 27 June 2024

2024-06-27T17:13:55Z

← Older revision		Revision as of 17:13, 27 June 2024
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	{\| class="wikitable"		{\| class="wikitable"
	\|+ MedKoo Cat#: 556370		\|+ [https://www.medkoo.com/products/58532 MedKoo Cat#: 556370]
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	! TERT activator compound (TAC)		! TERT activator compound (TAC)
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	\| '''Molecular Weight''': 331.762		\| '''Molecular Weight''': 331.762
	\|}		\|}
	'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref>Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref>		'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref>Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref><ref>[https://www.medkoo.com/products/58532 MedKoo Cat#: 556370] TERT activator compound (TAC) </ref>

	[[Category:Drugs]]		[[Category:Drugs]]
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Dmitry Dzhagarov at 16:41, 27 June 2024

2024-06-27T16:41:01Z

← Older revision		Revision as of 16:41, 27 June 2024
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			{\| class="wikitable"
			\|+ MedKoo Cat#: 556370
			\|-
			! TERT activator compound (TAC)
			\|-
			\| '''Synonym''': TAC-activator; TAC; TERT activator compound
			\|-
			\| '''CAS#''': 666699-46-3
			\|-
			\| '''IUPAC/Chemical Name''': Benzenesulfonamide, N-(3-chloro-4-fluorophenyl)-4-fluoro-3,5-dimethyl
			\|-
			\| '''Chemical Formula''': C<sub>14</sub>H<sub>12</sub>ClF<sub>2</sub>NO<sub>2</sub>S
			\|-
			\| '''Exact Mass''': 331.02
			\|-
			\| '''Molecular Weight''': 331.762
			\|}
	'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref>Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref>		'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref>Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref>

Dmitry Dzhagarov at 08:25, 27 June 2024

2024-06-27T08:25:27Z

← Older revision		Revision as of 08:25, 27 June 2024
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Dmitry Dzhagarov at 08:13, 27 June 2024

2024-06-27T08:13:00Z

← Older revision		Revision as of 08:13, 27 June 2024
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	'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of TERT in both human and mouse somatic tissues.<ref>Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref>		'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.<ref>Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref>

	[[Category:Drugs]]		[[Category:Drugs]]
	[[Category:Stub]]		[[Category:Stub]]