Dmitry Dzhagarov at 14:20, 22 March 2024

2024-03-22T14:20:09Z

← Older revision		Revision as of 14:20, 22 March 2024
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	WWP2 (WW domain containing E3 ubiquitin-protein ligase 2) is an enzyme that contains 4 tandem WW (double-tryptophan) domains, named after the presence of two conserved tryptophans (W).<ref>Chen, W., Jiang, X., & Luo, Z. (2014). WWP2: a multifunctional ubiquitin ligase gene. Pathology & Oncology Research, 20, 799-803. [https://pubmed.ncbi.nlm.nih.gov/25216927/ PMID: 25216927] DOI: 10.1007/s12253-014-9838-y</ref><ref>You, S., Xu, J., Guo, Y., Guo, X., Zhang, Y., Zhang, N., ... & Sun, Y. (2024). E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases. Molecular Aspects of Medicine, 96, 101257. [https://pubmed.ncbi.nlm.nih.gov/38430667/ PMID: 38430667] [https://doi.org/10.1016/j.mam.2024.101257 DOI: 10.1016/j.mam.2024.101257]</ref>		WWP2 (WW domain containing E3 ubiquitin-protein ligase 2) is an enzyme that contains 4 tandem WW (double-tryptophan) domains, named after the presence of two conserved tryptophans (W). WWP2 is a member of the Nedd4 superfamily, a small group within the E3 ubiquitin ligase enzymes and is involved in post-translational modifications.<ref>Chen, W., Jiang, X., & Luo, Z. (2014). WWP2: a multifunctional ubiquitin ligase gene. Pathology & Oncology Research, 20, 799-803. [https://pubmed.ncbi.nlm.nih.gov/25216927/ PMID: 25216927] DOI: 10.1007/s12253-014-9838-y</ref><ref>You, S., Xu, J., Guo, Y., Guo, X., Zhang, Y., Zhang, N., ... & Sun, Y. (2024). E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases. Molecular Aspects of Medicine, 96, 101257. [https://pubmed.ncbi.nlm.nih.gov/38430667/ PMID: 38430667] [https://doi.org/10.1016/j.mam.2024.101257 DOI: 10.1016/j.mam.2024.101257]</ref>

			WWP2 is dysregulated in various of tumors, and it promotes carcinogenesis mainly through PTEN/Akt signaling pathway. WWP2 also participates in anti-cancer agents' sensitivity, indicating WWP2 may be a novel target for cancer treatment.<ref>Zhang, R., Zhang, J., Luo, W. et al. (2019). WWP2 Is One Promising Novel Oncogene. Pathol. Oncol. Res. 25, 443–446 PMID: 30415470 [https://doi.org/10.1007/s12253-018-0506-5 DOI: 10.1007/s12253-018-0506-5]</ref> WWP2 can cause the ubiquitin-dependent degradation of specific tumor suppressor proteins (such as Oct4<ref>Liao, B., & Jin, Y. (2010). Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner. Cell research, 20(3), 332-344.</ref> and PTEN [229]) in many cancers [230].

			The tubulointerstitial expression of WWP2 was associated with fibrotic progression in CKD patients and in murine kidney disease models. WWP2 deficiency promoted myofibroblast proliferation and halts pro-fibrotic activation, reducing the severity of kidney fibrosis in vivo. In renal myofibroblasts, WWP2 deficiency increased fatty acid oxidation and activated the pentose phosphate pathway, boosting mitochondrial respiration at the expense of glycolysis. WWP2 suppressed the transcription of PGC-1α, a metabolic mediator of fibrotic response, and pharmacological inhibition of PGC-1α partially abrogated the protective effects of WWP2 deficiency on myofibroblasts.<ref>Chen, H., You, R., Guo, J., Zhou, W., Chew, G., Devapragash, N., ... & Petretto, E. (2024). WWP2 Regulates Kidney Fibrosis and the Metabolic Reprogramming of Profibrotic Myofibroblasts. Journal of the American Society of Nephrology, 10-1681. PMID: 38502123 DOI: 10.1681/ASN.0000000000000328</ref>

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Dmitry Dzhagarov: Created page with "WWP2 (WW domain containing E3 ubiquitin-protein ligase 2) is an enzyme that contains 4 tandem WW (double-tryptophan) domains, named after the presence of two conserved tryptophans (W).Chen, W., Jiang, X., & Luo, Z. (2014). WWP2: a multifunctional ubiquitin ligase gene. Pathology & Oncology Research, 20, 799-803. [https://pubmed.ncbi.nlm.nih.gov/25216927/ PMID: 25216927] DOI: 10.1007/s12253-014-9838-yYou, S., Xu, J., Guo, Y., Guo, X., Zhang, Y., Zhang, N.,..."

2024-03-22T10:19:59Z

Created page with "WWP2 (WW domain containing E3 ubiquitin-protein ligase 2) is an enzyme that contains 4 tandem WW (double-tryptophan) domains, named after the presence of two conserved tryptophans (W).<ref>Chen, W., Jiang, X., & Luo, Z. (2014). WWP2: a multifunctional ubiquitin ligase gene. Pathology & Oncology Research, 20, 799-803. [https://pubmed.ncbi.nlm.nih.gov/25216927/ PMID: 25216927] DOI: 10.1007/s12253-014-9838-y</ref><ref>You, S., Xu, J., Guo, Y., Guo, X., Zhang, Y., Zhang, N.,..."

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WWP2 (WW domain containing E3 ubiquitin-protein ligase 2) is an enzyme that contains 4 tandem WW (double-tryptophan) domains, named after the presence of two conserved tryptophans (W).<ref>Chen, W., Jiang, X., & Luo, Z. (2014). WWP2: a multifunctional ubiquitin ligase gene. Pathology & Oncology Research, 20, 799-803. [https://pubmed.ncbi.nlm.nih.gov/25216927/ PMID: 25216927] DOI: 10.1007/s12253-014-9838-y</ref><ref>You, S., Xu, J., Guo, Y., Guo, X., Zhang, Y., Zhang, N., ... & Sun, Y. (2024). E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases. Molecular Aspects of Medicine, 96, 101257. [https://pubmed.ncbi.nlm.nih.gov/38430667/ PMID: 38430667] [https://doi.org/10.1016/j.mam.2024.101257 DOI: 10.1016/j.mam.2024.101257]</ref>

== References ==
<references />
[[Category:Main list]]
[[Category:Age-related diseases]]
[[Category:Longevity genes]]
[[Category:Stub]]

Ubiquitin Ligase WWP2 - Revision history

Dmitry Dzhagarov at 14:20, 22 March 2024