GDF5 (Growth differentiation factor 5)
From Longevity Wiki
GDF5 (Growth differentiation factor 5) leads to a “rejuvenating” transcriptomic signature in aged mice, as 42% of the transcripts dysregulated by ageing reverted to youthful expression levels and (17,8% of absolute maximal force increase) upon treating chronically (for 4 months) aged mice using recombinant GDF5 protein (rGDF5) in systemic administration.[1]
- ↑ Massiré, T., Chiara, N., Amélie, V., Christel, G., Marius, H., Lucile, S., ... & Sestina, F. (2024). GDF5 as a rejuvenating treatment for age-related neuromuscular failure. Brain, awae107. https://doi.org/10.1093/brain/awae107
