From Longevity Wiki

Geroprotectors are substances that slow down aging process and can be used as senotherapeutics for prevention of age-related diseases.[1][2][3] Geroprotectors can improve functioning of various organ systems and enhance their homeostatic capabilities.

There is a database of geroprotectors, Geroprotectors, which structures data on studies of potential geroprotectors.[4] There is also DrugAge (, a curated database of lifespan-extending drugs and compounds.[5]


  1. Moskalev, A. A. (2023). Potential Geroprotectors–From Bench to Clinic. Biochemistry (Moscow), 88(11), 1732-1738.
  2. Janssens, G. E., & Houtkooper, R. H. (2020). Identification of longevity compounds with minimized probabilities of side effects. Biogerontology, 21(6), 709-719. PMID: 32562114 PMC7541369 DOI: 10.1007/s10522-020-09887-7
  3. Liu, J. K. (2022). Antiaging agents: safe interventions to slow aging and healthy life span extension. Natural Products and Bioprospecting, 12(1), 1-36. PMID 35534591 PMC 9086005 doi:10.1007/s13659-022-00339-y
  4. Moskalev, A., Chernyagina, E., de Magalhães, J. P., Barardo, D., Thoppil, H., Shaposhnikov, M., ... & Zhavoronkov, A. (2015). Geroprotectors. org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging (Albany NY), 7(9), 616. PMID: 26342919 PMC4600621 DOI: 10.18632/aging.100799
  5. Barardo, D., Thornton, D., Thoppil, H., Walsh, M., Sharifi, S., Ferreira, S., ... & de Magalhães, J. P. (2017). The DrugAge database of aging‐related drugs. Aging cell, 16(3), 594-597. PMID: 28299908 PMC5418190 DOI: 10.1111/acel.12585