Granzyme B

Granzymes, a family of serine proteases with intracellular cytotoxic and/or proinflammatory functions, are increasingly recognized for their emerging roles in biological aging and disease. Widely recognized as intracellular mediators of cell death, granzymes, particularly granzyme B (GzmB) is observed in numerous age-related conditions, also accumulate in the extracellular milieu of tissues with age, contributing to chronic tissue injury, inflammation, and impaired healing. Genetic deletion and/or pharmacological inhibition of granzyme B reduces premature aging and/or disease phenotypes in animal models.^[1]

VTI-1002, a small molecule, specific inhibitor against GzmB

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↑ Richardson, K. C., Jung, K., Matsubara, J. A., Choy, J. C., & Granville, D. J. (2024). Granzyme B in aging and age-related pathologies. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2024.07.010
↑ Shen, Y., Zeglinski, M. R., Turner, C. T., Raithatha, S. A., Wu, Z., Russo, V., ... & Granville, D. J. (2018). Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing. Experimental & molecular medicine, 50(5), 1-11. PMID: 29849046 PMC5976625 DOI: 10.1038/s12276-018-0095-0

[1] Richardson, K. C., Jung, K., Matsubara, J. A., Choy, J. C., & Granville, D. J. (2024). Granzyme B in aging and age-related pathologies. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2024.07.010

[2] Shen, Y., Zeglinski, M. R., Turner, C. T., Raithatha, S. A., Wu, Z., Russo, V., ... & Granville, D. J. (2018). Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing. Experimental & molecular medicine, 50(5), 1-11. PMID: 29849046 PMC5976625 DOI: 10.1038/s12276-018-0095-0

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