From Longevity Wiki
Formula C17H26O3
Molecular Weight 278.39

Isofalcarintriol ((3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol) is a polyacetylene contained in the root of carrots (Daucus carota), which was revealed as potent promoter of longevity in the nematode C. elegans even at remarkably low doses.[1] Isofalcarintriol, like most C17-polyacetylene phytochemicals,[2][3][4] can reduce risk of inflammation and cancer and thus extends lifespan and promote health in models of age-associated diseases including diabetes, tumor cell growth, and of neurodegenerative diseases.[1][5]

Supplementation of isofalcarintriol to mice on high-fat diet improves glucose metabolism and increases murine exercise endurance during treadmill training, thus representing an exercise mimetic. Interestingly, a similar trend was seen in isofalcarintriol-treated aged mice, suggesting a potential improvement of frailty.[1] Isofalcarintriol treatment provoked an initial ROS signal and a subsequent activation of nuclear factor erythroid 2-related factor 2 (Nrf2), eventually increasing oxidative stress resistance long term.[1]


  1. 1.0 1.1 1.2 1.3 Thomas, C., Erni, R., Wu, J. Y., Fischer, F., Lamers, G., Grigolon, G., ... & Ristow, M. (2023). A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging. Nature Communications, 14(1), 8142. PMID:38065964 PMC:10709416 DOI:10.1038/s41467-023-43672-7
  2. Alfurayhi, R., Huang, L., & Brandt, K. (2023). Pathways Affected by Falcarinol-Type Polyacetylenes and Implications for Their Anti-Inflammatory Function and Potential in Cancer Chemoprevention. Foods, 12(6), 1192. PMID:36981118 PMC:10048309 DOI:10.3390/foods12061192
  3. Dawid, C., Dunemann, F., Schwab, W., Nothnagel, T., & Hofmann, T. (2015). Bioactive C17-polyacetylenes in carrots (Daucus carota L.): current knowledge and future perspectives. Journal of Agricultural and Food Chemistry, 63(42), 9211-9222. PMID:26451696 DOI:10.1021/acs.jafc.5b04357
  4. Christensen, L. P., & Brandt, K. (2006). Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. Journal of pharmaceutical and biomedical analysis, 41(3), 683-693. PMID: 16520011 DOI: 10.1016/j.jpba.2006.01.057
  5. Mandrich, L., Esposito, A. V., Costa, S., & Caputo, E. (2023). Chemical Composition, Functional and Anticancer Properties of Carrot. Molecules, 28(20), 7161. PMID:37894640 PMC:10608851 DOI|10.3390/molecules28207161