LOY-001
LOY-001 is the long-acting drug intended to extend lifespan and healthspan for large and giant breed dogs.[1][2] LOY-001, is an injection-based treatment that targets Insulin-like growth factor 1 (IGF-1), also called somatomedin C. IGF-1 binds and activates its own receptor, IGF-1R, through the cell surface expression of Receptor Tyrosine Kinase's (RTK's)[3] and further signal through multiple intracellular transduction cascades. IGF-1R is the critical role-playing inducer in modulating the metabolic effects of IGF-1 for cellular senescence, longevity and survival.[4]
This hormone seems to be size-related—it appears in higher levels in larger dogs and in lower levels in smaller dogs and obviously this explains the fact that large and giant breed dogs have average life expectancies that are only half that of the smallest breeds.[5][6][7] Research has shown that inhibiting IGF-1 in flies, worms and rodents can increase their lifespans.[8][9]
LOY-001 is some kind of antisense RNA designed for healthy dogs over the age of seven and above 40 pounds, and it would be administered every three to six months by a veterinarian.
As Dr Brennen McKenzie, director of veterinary medicine at Loyal, told: “From a biological point of view, if particular drugs that we or other companies develop are successful at extending healthspan and lifespan in dogs. Those are also going to be reasonable targets in human medicine.”[10]
References
- ↑ A San Francisco-based biotech & veterinary medicine firm Loyal (November 28, 2023) FDA Center for Veterinary Medicine agrees Loyal’s data supports reasonable expectation of effectiveness for large dog lifespan extension. Loyal. Cellular Longevity, Inc.
- ↑ Mullin E. (November 28, 2023). A Life-Extension Drug for Big Dogs Is Getting Closer to Reality. WIRED
- ↑ Laron, Z. (2001). Insulin-like growth factor 1 (IGF-1): a growth hormone. Molecular Pathology, 54(5), 311. PMC1187088
- ↑ Junnila, R. K., List, E. O., Berryman, D. E., Murrey, J. W., & Kopchick, J. J. (2013). The GH/IGF-1 axis in ageing and longevity. Nature Reviews Endocrinology, 9(6), 366-376. PMID: 23591370 PMC4074016 DOI: 10.1038/nrendo.2013.67
- ↑ Socha, S., Mironska, M., & Kolodziejczyk, D. (2022). Analysis of factors affecting the quality and length of life of dogs. Acta Scientiarum Polonorum. Zootechnica, 21(3). DOI: 10.21005/asp.2022.21.3.01
- ↑ Mazzatenta, A., Carluccio, A., Robbe, D., Di Giulio, C., & Cellerino, A. (2017). The companion dog as a unique translational model for aging. In Seminars in cell & developmental biology (Vol. 70, pp. 141-153). Academic Press. PMID: 28803893 DOI: 10.1016/j.semcdb.2017.08.024
- ↑ Brennen McKenzie (September 2022) Why do big dogs have unusually short lifespans compared to small dogs? Loyal. Cellular Longevity, Inc.
- ↑ Duran-Ortiz, S., List, E. O., Basu, R., & Kopchick, J. J. (2021). Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age. Pituitary, 24(3), 438-456. PMID: 33459974 PMC8122064 DOI: 10.1007/s11102-020-01117-0
- ↑ Hou, Y. L., Wang, Y. F., Qiao, S. O. N. G., Zhang, X. M., Jing, L. I. U., Wang, Y. Q., ... & Wang, P. C. (2022). IGF-1 Accelerates Cell Aging by Inhibiting POLD1 Expression. Biomedical and Environmental Sciences, 35(11), 981-991. PMID: 36443251 DOI: 10.3967/bes2022.127
- ↑ Pinkstone J., (October 2023). Dogs could have lifespan extended with promising new drug. The Telegraph
