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In 2022, scientists from Tufts University showed for the first time that regeneration of the hindlimb of a frog after amputation was possible. This was done in the adult African clawed frog (Xenopus laevis) after amputation, something that is not known to happen in nature. They demonstrated 18 months of regrowth of the limb with only 24-hour exposure to a combination of drugs delivered by a wearable bioreactor. The regenerated limb included skin, bone, vasculature and nerves.
- Murugan, N. J., Vigran, H. J., Miller, K. A., Golding, A. Pham, Q. L., Sperry, M. M., Rasmussen-Ivey, C., Kane, A. W., Kaplan, D. L., & Levin, M. (2022). Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis. Science Advances, 8(4), https://doi.org/10.1126/sciadv.abj2164