Longevity quotient

Longevity quotient (LQ) is a simplified measure to enable normalized comparisons of various species' longevity.^[1] LQ gives an indication of how long a species’ lifespan is compared with other species of similar size, where LQ = observed longevity/expected longevity.^[2] Mean longevity quotient allows to identify of long-lived species.^[3]

The Longevity Quotient is the ratio of actual maximum species life span (MLSP) to that predicted by body mass.^[4] It evaluates the manifestation of Peto's paradox in its evolutionary interpretation as the ability to grow for a long time and, accordingly, to age for a long time in different animals.^[5]^[6]

References

↑ Palmore, E. (1969). Predicting longevity: A follow-up controlling for age. The Gerontologist, 9(4_Part_1), 247-250.
↑ Austad, S. N., & Fischer, K. E. (1991). Mammalian aging, metabolism, and ecology: evidence from the bats and marsupials. Journal of gerontology, 46(2), B47-B53. PMID: 1997563 DOI: 10.1093/geronj/46.2.b47
↑ Yu, Z., Seim, I., Yin, M., Tian, R., Sun, D., Ren, W., ... & Xu, S. (2021). Comparative analyses of aging-related genes in long-lived mammals provide insights into natural longevity. The Innovation, 2(2). PMID: 34557758 PMC8454735 DOI: 10.1016/j.xinn.2021.100108
↑ Hulbert, A. J. (2008). Explaining longevity of different animals: is membrane fatty acid composition the missing link?. Age, 30(2-3), 89-97.
↑ Roche, B., Hochberg, M. E., Caulin, A. F., Maley, C. C., Gatenby, R. A., Misse, D., & Thomas, F. (2012). Natural resistance to cancers: a Darwinian hypothesis to explain Peto’s paradox. BMC cancer, 12(1), 1-4. PMID: 22943484 PMCID: PMC3488527 DOI: 10.1186/1471-2407-12-387
↑ Perillo, M., Silla, A., Punzo, A., Caliceti, C., Kriete, A., Sell, C., & Lorenzini, A. (2023). Peto’s paradox: nature has used multiple strategies to keep cancer at bay while evolving long lifespans and large body masses. A systematic mini-review. Biomedical journal, 100654. PMID: 37604250 DOI: 10.1016/j.bj.2023.100654

[1] Palmore, E. (1969). Predicting longevity: A follow-up controlling for age. The Gerontologist, 9(4_Part_1), 247-250.

[2] Austad, S. N., & Fischer, K. E. (1991). Mammalian aging, metabolism, and ecology: evidence from the bats and marsupials. Journal of gerontology, 46(2), B47-B53. PMID: 1997563 DOI: 10.1093/geronj/46.2.b47

[3] Yu, Z., Seim, I., Yin, M., Tian, R., Sun, D., Ren, W., ... & Xu, S. (2021). Comparative analyses of aging-related genes in long-lived mammals provide insights into natural longevity. The Innovation, 2(2). PMID: 34557758 PMC8454735 DOI: 10.1016/j.xinn.2021.100108

[4] Hulbert, A. J. (2008). Explaining longevity of different animals: is membrane fatty acid composition the missing link?. Age, 30(2-3), 89-97.

[5] Roche, B., Hochberg, M. E., Caulin, A. F., Maley, C. C., Gatenby, R. A., Misse, D., & Thomas, F. (2012). Natural resistance to cancers: a Darwinian hypothesis to explain Peto’s paradox. BMC cancer, 12(1), 1-4. PMID: 22943484 PMCID: PMC3488527 DOI: 10.1186/1471-2407-12-387

[6] Perillo, M., Silla, A., Punzo, A., Caliceti, C., Kriete, A., Sell, C., & Lorenzini, A. (2023). Peto’s paradox: nature has used multiple strategies to keep cancer at bay while evolving long lifespans and large body masses. A systematic mini-review. Biomedical journal, 100654. PMID: 37604250 DOI: 10.1016/j.bj.2023.100654

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