Nicotinamide N-methyltransferase inhibitors (NNMTis)
Nicotinamide N-methyltransferase inhibitors (NNMTis) treatment could surpass the muscle health benefits of resistance and endurance exercise. NNMTi (5-amino-1-methylquinolinium iodide[1]) treatment prevents age-associated loss of strength and actively rebuilds strength. Moreover, NNMTi treatment almost doubled the increase in muscle strength compared to exercise alone. The increases in muscle strength resulting from NNMTi treatment or exercise were additive, with the strength of the NNMTi-treated exercise cohort being increased by ~ 60% compared to the control cohort.[2] These studies suggest that NNMTi-based drugs, either alone or combined with exercise, will be beneficial in treating sarcopenia and a wide range of age-related myopathies.
- ↑ Neelakantan, H., Wang, H. Y., Vance, V., Hommel, J. D., McHardy, S. F., & Watowich, S. J. (2017). Structure–activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. Journal of medicinal chemistry, 60(12), 5015-5028.
- ↑ Dimet-Wiley, A.L., Latham, C.M., Brightwell, C.R. et al. (2024). Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Sci Rep 14, 15554 https://doi.org/10.1038/s41598-024-66034-9
