OSER1 gene
From Longevity Wiki
OSER1 (Oxidative stress-responsive serine-rich protein 1) is an evolutionarily conserved FOXO-regulated protein that improves resistance to oxidative stress, maintains mitochondrial functional integrity, and increases lifespan in multiple species. OSER1 overexpression extends lifespan in silkworms, nematodes, and flies, while its depletion correspondingly shortens lifespan. Human proteomic analysis suggests that OSER1 plays roles in oxidative stress response, cellular senescence, and reproduction. Human studies demonstrate that polymorphic variants in OSER1 are associated with human longevity.[1]
- ↑ Song, J., Li, Z., Zhou, L. et al. FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species. Nat Commun 15, 7144 (2024). https://doi.org/10.1038/s41467-024-51542-z
