From Longevity Wiki
This article is currently a draft.
Material may not yet be complete, information may presently be omitted, and certain parts of the content may be subject to radical, rapid alteration. More information pertaining to this may be available on the talk page.
Proteostasis refers to the rate or turnover of synthesis and degradation (proteolysis) of misfolded and damaged proteins. Proteostasis helps maintain cellular and protein homeostasis and is regulated by the ubiquitin/proteasome system (UPS).
Loss of proteostasis is considered to be a hallmark of aging, and several ubiquitin-dependent protein degradation pathways have been shown to regulate lifespan.
- ↑ Hoppe T. Life and destruction: ubiquitin-mediated proteolysis in aging and longevity. F1000 Biol Rep. 2010 Nov 11;2:79. doi: 10.3410/B2-79. PMID: 21151840; PMCID: PMC2998811.
- ↑ López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.