Proteostasis

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Proteostasis refers to the rate or turnover of synthesis and degradation (proteolysis) of misfolded and damaged proteins. Proteostasis helps maintain cellular and protein homeostasis and is regulated by the ubiquitin/proteasome system (UPS).

Loss of proteostasis is considered to be a hallmark of aging, and several ubiquitin-dependent protein degradation pathways have been shown to regulate lifespan.