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Proteostasis refers to the rate or turnover of synthesis and degradation (proteolysis) of misfolded and damaged proteins. Proteostasis helps maintain cellular and protein homeostasis and is regulated by the ubiquitin/proteasome system (UPS).[1]

Loss of proteostasis is considered to be a hallmark of aging,[2] and several ubiquitin-dependent protein degradation pathways have been shown to regulate lifespan.

  1. Hoppe T. Life and destruction: ubiquitin-mediated proteolysis in aging and longevity. F1000 Biol Rep. 2010 Nov 11;2:79. doi: 10.3410/B2-79. PMID: 21151840; PMCID: PMC2998811.
  2. López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.