Rejuvant
Rejuvant®, an alpha-ketoglutarate based formulation that was found to extend lifespan and delay the onset of age-associated decline in experimental models such as nematodes, fruit flies, yeasts, and mice.[1][2][3] Alpha-ketoglutarate (AKG) is involved in pleiotropic metabolic and regulatory pathways in the cell, including energy production, biosynthesis of certain amino acids, collagen biosynthesis, epigenetic regulation of gene expression, regulation of redox homeostasis, and detoxification of hazardous substances.[4][5]
The formulation of the Rejuvant® supplement is itself different for males and females. More specifically, in addition to CaAKG (Calcium Alpha-Ketoglutarate Monohydrate (LifeAKG™) 1000 mg + 190 mg Calcium), vitamin A (as retinyl palmitate 900 mcg) and vitamin D (25 mcg) are added to the men’s or women’s commercial formulation, respectively.[1]
References
- ↑ 1.0 1.1 Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer III, F. R., Kennedy, B. K., & Budovskaya, Y. V. (2021). Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (albany NY), 13(22), 24485. PMID: 34847066 PMC8660611 DOI: 10.18632/aging.203736
- ↑ Naeini, S. H., Mavaddatiyan, L., Kalkhoran, Z. R., Taherkhani, S., & Talkhabi, M. (2023). Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives. Experimental Gerontology, 175, 112154. PMID: 36934991 DOI: 10.1016/j.exger.2023.112154
- ↑ Shahmirzadi, A. A., Edgar, D., Liao, C. Y., Hsu, Y. M., Lucanic, M., Shahmirzadi, A. A., ... & Lithgow, G. J. (2020). Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell metabolism, 32(3), 447-456. PMID: 32877690 PMCID: PMC8508957 DOI: 10.1016/j.cmet.2020.08.004
- ↑ Zdzisińska, B., Żurek, A., & Kandefer-Szerszeń, M. (2017). Alpha-ketoglutarate as a molecule with pleiotropic activity: well-known and novel possibilities of therapeutic use. Archivum immunologiae et therapiae experimentalis, 65, 21-36. PMID: 27326424 PMC5274648 DOI: 10.1007/s00005-016-0406-x
- ↑ Bayliak, M. M., & Lushchak, V. I. (2021). Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent. Ageing Research Reviews, 66, 101237. PMID: 33340716 DOI: 10.1016/j.arr.2020.101237
