Savior sibling technology for rejuvenation

Savior sibling technology for rejuvenation was originally developed in 2004 by Anver Kuliev & Yury Verlinsky.^[1]^[2] A savior baby or savior sibling is a child who is conceived using preimplantation genetic diagnosis (PGD) in order to provide multiple times a stem cell transplant to a sibling that needs rejuvenation through cell therapy.^[3] Stem cell transplants and exosomes are regularly isolated from donor urine.^[4]^[5]^[6]^[7]

References

↑ Kuliev A. & Verlinsky Y. (2004). Preimplantation HLA typing and stem cell transplantation: report of International Meeting, Cyprus, 27–28 March, PMID: 15354311 DOI: 10.1016/s1472-6483(10)62131-1
↑ Kuliev, A., Rechitsky, S., TUR‐KASPA, I. L. A. N., & Verlinsky, Y. (2005). Preimplantation genetics: improving access to stem cell therapy. Annals of the New York Academy of Sciences, 1054(1), 223-227. PMID: 16339669 DOI: 10.1196/annals.1345.028
↑ Tian, Y., Li, M., Yang, J. et al. (2024). Preimplantation genetic testing in the current era, a review. Arch Gynecol Obstet. PMID: 38376520 DOI: 10.1007/s00404-024-07370-z
↑ Dan, Q. Q., Chen, L., Shi, L. L., Zhou, X., Wang, T. H., & Liu, H. (2023). Urine-derived mesenchymal stem cells-derived exosomes enhances survival and proliferation of aging retinal ganglion cells. BMC Molecular and Cell Biology, 24(1), 8. PMID: 36879194 PMCID: PMC9990288 DOI: 10.1186/s12860-023-00467-4
↑ Cavaleiro, C., Afonso, G. J., Oliveira, P. J., Valero, J., Mota, S. I., & Ferreiro, E. (2023). Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions. Frontiers in Molecular Neuroscience, 16. PMID: 37965041 PMC10642248 DOI: 10.3389/fnmol.2023.1229728
↑ Yu, P., Bosholm, C. C., Zhu, H., Duan, Z., Atala, A., & Zhang, Y. (2024). Beyond waste: understanding urine’s potential in precision medicine. Trends in Biotechnology. PMID: 38369434 DOI: 10.1016/j.tibtech.2024.01.009
↑ Rao, S., He, Z., Wang, Z., Yin, H., Hu, X., Tan, Y., ... & Chen, C. (2024). Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1. Acta Pharmaceutica Sinica B, 14(3), 1166-1186. https://doi.org/10.1016/j.apsb.2023.12.009

[1] Kuliev A. & Verlinsky Y. (2004). Preimplantation HLA typing and stem cell transplantation: report of International Meeting, Cyprus, 27–28 March, PMID: 15354311 DOI: 10.1016/s1472-6483(10)62131-1

[2] Kuliev, A., Rechitsky, S., TUR‐KASPA, I. L. A. N., & Verlinsky, Y. (2005). Preimplantation genetics: improving access to stem cell therapy. Annals of the New York Academy of Sciences, 1054(1), 223-227. PMID: 16339669 DOI: 10.1196/annals.1345.028

[3] Tian, Y., Li, M., Yang, J. et al. (2024). Preimplantation genetic testing in the current era, a review. Arch Gynecol Obstet. PMID: 38376520 DOI: 10.1007/s00404-024-07370-z

[4] Dan, Q. Q., Chen, L., Shi, L. L., Zhou, X., Wang, T. H., & Liu, H. (2023). Urine-derived mesenchymal stem cells-derived exosomes enhances survival and proliferation of aging retinal ganglion cells. BMC Molecular and Cell Biology, 24(1), 8. PMID: 36879194 PMCID: PMC9990288 DOI: 10.1186/s12860-023-00467-4

[5] Cavaleiro, C., Afonso, G. J., Oliveira, P. J., Valero, J., Mota, S. I., & Ferreiro, E. (2023). Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions. Frontiers in Molecular Neuroscience, 16. PMID: 37965041 PMC10642248 DOI: 10.3389/fnmol.2023.1229728

[6] Yu, P., Bosholm, C. C., Zhu, H., Duan, Z., Atala, A., & Zhang, Y. (2024). Beyond waste: understanding urine’s potential in precision medicine. Trends in Biotechnology. PMID: 38369434 DOI: 10.1016/j.tibtech.2024.01.009

[7] Rao, S., He, Z., Wang, Z., Yin, H., Hu, X., Tan, Y., ... & Chen, C. (2024). Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1. Acta Pharmaceutica Sinica B, 14(3), 1166-1186. https://doi.org/10.1016/j.apsb.2023.12.009

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