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- 12:34, 25 March 2024 Dmitry Dzhagarov talk contribs created page Small nucleoli as a visible cellular hallmark of longevity and metabolic health (Created page with "The nucleolus is a nuclear subcompartment where ribosomal RNA is synthesized and assembled into ribosomal subunits. It is a dynamic organelle subject to inputs from growth signalling pathways, nutrients, and stress, whose size correlates with rRNA synthesis.<ref>Boulon, S., Westman, B. J., Hutten, S., Boisvert, F. M., & Lamond, A. I. (2010). The nucleolus under stress. Molecular cell, 40(2), 216-227. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987465/ PMC2987465/] doi...")
- 23:17, 24 March 2024 User account Jesper2k talk contribs was created
- 10:19, 22 March 2024 Dmitry Dzhagarov talk contribs created page Ubiquitin Ligase WWP2 (Created page with "WWP2 (WW domain containing E3 ubiquitin-protein ligase 2) is an enzyme that contains 4 tandem WW (double-tryptophan) domains, named after the presence of two conserved tryptophans (W).<ref>Chen, W., Jiang, X., & Luo, Z. (2014). WWP2: a multifunctional ubiquitin ligase gene. Pathology & Oncology Research, 20, 799-803. [https://pubmed.ncbi.nlm.nih.gov/25216927/ PMID: 25216927] DOI: 10.1007/s12253-014-9838-y</ref><ref>You, S., Xu, J., Guo, Y., Guo, X., Zhang, Y., Zhang, N.,...")
- 17:24, 17 March 2024 Dmitry Dzhagarov talk contribs created page Squalene (Created page with "'''Squalene''' is a polyunsaturated triterpenoid compound with the formula C<sub>30</sub>H<sub>50</sub> present as biochemical precursor in sterol biosynthesis, including cholesterol and steroid hormones in various organisms.<ref>Micera, M., Botto, A., Geddo, F., Antoniotti, S., Bertea, C. M., Levi, R., ... & Querio, G. (2020). Squalene: More than a step toward sterols. Antioxidants, 9(8), 688. PMID: 32748847 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464659/ PMC7464...")
- 09:56, 17 March 2024 Dmitry Dzhagarov talk contribs created page Savior sibling technology for rejuvenation (Created page with "'''Savior sibling technology for rejuvenation''' was originally developed in 2004 by Anver Kuliev & Yury Verlinsky.<ref>Kuliev A. & Verlinsky Y. (2004). Preimplantation HLA typing and stem cell transplantation: report of International Meeting, Cyprus, 27–28 March, PMID: 15354311 [https://www.rbmojournal.com/article/S1472-6483(10)62131-1/pdf DOI: 10.1016/s1472-6483(10)62131-1]</ref><ref>Kuliev, A., Rechitsky, S., TUR‐KASPA, I. L. A. N., & Verlinsky, Y. (2005). Preimpl...")
- 20:19, 4 March 2024 Dmitry Dzhagarov talk contribs created page Age-related hearing loss (Created page with "'''Age-related hearing loss (or presbycusis)''' is the gradual loss of hearing in both ears. It's a common problem linked to aging. Presbycusis is a complex multidimensional disorder, in addition to aging, multiple factors including exposure to noise, or ototoxic agents, genetic susceptibility, metabolic diseases and lifestyle can influence the onset and severity of presbycusis. Nevertheless, among this variety of factors involved in hearing loss, aging is one of the mos...")
- 16:40, 27 February 2024 User account BuyDofollowblogcomments talk contribs was created
- 19:14, 22 February 2024 Dmitry Dzhagarov talk contribs created page TUDCA (tauroursodeoxycholic acid) (Created page with "'''TUDCA (tauroursodeoxycholic acid)''' is a taurine conjugate of ursodeoxycholic acid (UDCA) with chemical chaperone activity.<ref>Chen, Y., Liu, C. P., Xu, K. F., Mao, X. D., Lu, Y. B., Fang, L., ... & Liu, C. (2008). Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes. American journal of nephrology, 28(6), 1014-1022.</ref> TUDCA is a minor component of h...") Tag: Visual edit: Switched
- 09:07, 22 February 2024 Dmitry Dzhagarov talk contribs created page Aging-related epigenetic changes (Created page with "Epigenetics, a rapidly evolving field, refers to the study of modifications to gene expression that does not alter the DNA sequence. Epigenetic dysregulation is both a hallmark and a driver of aging and restoring epigenetic integrity can reverse aging phenotypes.<ref>Pereira, B., Correia, F. P., Alves, I. A., Costa, M., Gameiro, M., Martins, A. P., & Saraiva, J. A. (2024). Epigenetic Reprogramming as a Key to Reverse Ageing and Increase Longevity. Ageing Research Reviews...")
- 18:54, 16 February 2024 Dmitry Dzhagarov talk contribs created page GV1001 (Created page with "Redirect")
- 08:59, 10 February 2024 Dmitry Dzhagarov talk contribs created page KEEY - Longevity Supplement (Created page with "[https://shop.extensia.life/products/keey? '''KEEY'''] is the longevity supplement, formulated with 10 scientifically backed ingredients in every pill: *. '''Nicotinamide Mononucleotide (NMN)''': Key in enhancing lifespan and energy output. - 260 mg *. '''D-Glucosamine Hydrochloride''': Promotes skin health by boosting collagen levels, leading to reduced wrinkles and visible signs of aging. - 480 mg *. '''Spermidine 3HCl''': Linked to extending lifespan by up to 30% i...")
- 09:34, 9 February 2024 Dmitry Dzhagarov talk contribs created page Intrinsic capacity (Created page with "'''Intrinsic capacity''' is a composite of five domains that summarizes the physical and mental capacities of an individual: '''sensorial, cognition, nutrition, mobility,''' and '''psychological''' as defined by the World Health Organization.<ref>Zhou, Y., & Ma, L. (2022). Intrinsic capacity in older adults: recent advances. Aging and disease, 13(2), 353. PMID: 35371613 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947834/ PMC8947834] DOI: 10.14336/AD.2021.0818</ref><re...")
- 08:11, 7 February 2024 Dmitry Dzhagarov talk contribs created page Rejuvant (Created page with "'''Rejuvant®''', an alpha-ketoglutarate based formulation that was found to extend lifespan and delay the onset of age-associated decline in experimental models such as nematodes, fruit flies, yeasts, and mice.<ref>Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer III, F. R., Kennedy, B. K., & Budovskaya, Y. V. (2021). Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction...")
- 18:52, 3 February 2024 Dmitry Dzhagarov talk contribs created page Minoxidil (Created page with "'''Minoxidil''' is a potassium channel opener vasodilator.<ref>Nawar, T., Nolin, L., Plante, G. E., Caron, C., & Montambault, P. (1977). Long-term treatment of severe hypertension with minoxidil. Canadian Medical Association Journal, 117(10), 1178. PMID: 603847 PMC1880293</ref><ref>Campese, V. M. (1981). Minoxidil: a review of its pharmacological properties and therapeutic use. Drugs, 22, 257-278. https://doi.org/10.2165/00003495-198122040-00001</ref><ref>Gupta, A. K.,...") Tag: Visual edit: Switched
- 15:44, 22 January 2024 Dmitry Dzhagarov talk contribs created page File:Super-enhancer-associated oncogenes.jpg
- 15:44, 22 January 2024 Dmitry Dzhagarov talk contribs uploaded File:Super-enhancer-associated oncogenes.jpg
- 07:13, 13 January 2024 Dmitry Dzhagarov talk contribs created page Six major anti-aging drugs and their related signal pathways, (Created page with "Six major anti-aging drugs and their related signal pathways (with 6 circuit illustrations) according to Nannan Du et al. and Qiang Sun:<ref>Du, N., Yang, R., Jiang, S., Niu, Z., Zhou, W., Liu, C., ... & Sun, Q. (2024). Anti-Aging Drugs and the Related Signal Pathways. Biomedicines, 12(1), 127. https://doi.org/10.3390/biomedicines12010127</ref> #. '''Rapamycin''' and the Aging-Related '''mTOR''' Signal Pathway #. '''Metformin''' and the Aging-Related '''AMPK'''...")
- 11:42, 12 January 2024 Dmitry Dzhagarov talk contribs created page Body mass index (BMI) (Created page with "'''Body mass index (BMI)''' is defined as the body mass divided by the square of the body height, and is expressed in units of kg/m<sup>2</sup>, resulting from mass in kilograms (kg) and height in metres (m). The BMI is expressed in kg/m2, resulting from mass in kilograms and height in metres. If pounds and inches are used, a conversion factor of 703 (kg/m2)/(lb/in2) is applied. BMI = mass<sub>kg</sub>/height<sub>m<sup>2</sup></sub> = 703 x mass<sub>lb</sub>/...")
- 08:00, 11 January 2024 Dmitry Dzhagarov talk contribs created page G-quadruplex (G4)-driven epigenomic aging (Created page with " <ref>Sen D, Gilbert W (1988). Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis. Nature. 334 (6180): 364–6. Bibcode:1988Natur.334..364S. doi:10.1038/334364a0. PMID 3393228</ref> <ref>Routh ED, Creacy SD, Beerbower PE, Akman SA, Vaughn JP, Smaldino PJ (2017). A G-quadruplex DNA-affinity Approach for Purification of Enzymaticacvly Active G4 Resolvase1. Journal of Visualized Experiments. 121 (121). doi:10.3791/5...")
- 06:43, 5 January 2024 Dmitry Dzhagarov talk contribs created page Isofalcarintriol (Created page with "{| class="wikitable" |- ! Isofalcarintriol |- | thumb |- | Formula C<sub>17</sub>H<sub>26</sub>O<sub>3</sub> |- | Molecular Weight 278.39 |} '''Isofalcarintriol''' ((3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol) is a polyacetylene contained in the root of carrots (Daucus carota), which was revealed as potent promoter of longevity in the nematode ''C. elegans'' even at remarkably low doses.<ref name="carrots" >Thomas, C., Erni,...")
- 06:27, 5 January 2024 Dmitry Dzhagarov talk contribs created page File:Isofalcarintriol.jpg
- 06:27, 5 January 2024 Dmitry Dzhagarov talk contribs uploaded File:Isofalcarintriol.jpg
- 09:56, 27 December 2023 Dmitry Dzhagarov talk contribs created page Taurine (Created page with "'''Taurine''', or 2-aminoethane sulfonic acid, is a conditionally essential amino acid. It can be obtained either exogenously through dietary sources or endogenously through biosynthesis from methionine and cysteine precursors, both essential sulfurcontaining alpha-amino acids. Taurine is known to be an inhibitory neurotransmitter and neuromodulator. In humans, small clinical trials of taurine supplementation in adults have suggested benefits in metabolic and inflammator...")
- 19:52, 26 December 2023 Dmitry Dzhagarov talk contribs created page File:CHIP (clonal hematopoiesis of indeterminate potential).jpg
- 19:52, 26 December 2023 Dmitry Dzhagarov talk contribs uploaded File:CHIP (clonal hematopoiesis of indeterminate potential).jpg
- 18:04, 26 December 2023 Dmitry Dzhagarov talk contribs created page CHIP phenomenon as a risk factor for atherosclerosis (Created page with "'''CHIP (clonal hematopoiesis of indeterminate potential)''' is an age-related disorder characterized by the acquisition of somatic mutations in hematopoietic stem cells that confer on these cells a selective advantage. As a consequence, instead of the normal polyclonal generation of blood cells, mutation-containing clones expand over time and make up an increasing percentage of the stem cells and their progeny and may include granulocytes, lymphocytes, and monocytes. CH...")
- 19:59, 17 December 2023 Dmitry Dzhagarov talk contribs created page HALD (Created page with "'''HALD''' is a text mining-based '''human aging and longevity dataset''' of the biomedical knowledge graph from all published literature related to human aging and longevity in PubMed. HALD integrated multiple state-of-the-art natural language processing (NLP) techniques to improve the accuracy and coverage of the knowledge graph for precision gerontology and geroscience analyses.<ref>Wu, Z., Feng, C., Hu, Y., Zhou, Y., Li, S., Zhang, S., ... & Chen, M. (2023). HALD, a...")
- 07:01, 14 December 2023 Dmitry Dzhagarov talk contribs created page File:The two primary molecular regulators of lifespan.jpg
- 07:01, 14 December 2023 Dmitry Dzhagarov talk contribs uploaded File:The two primary molecular regulators of lifespan.jpg
- 16:43, 13 December 2023 Dmitry Dzhagarov talk contribs created page VoyAGEr: free web interface for the analysis of age-related gene expression alterations in human tissues (Redirected page to Human Ageing Genomic Resources#VoyAGEr: free web interface for the analysis of age-related gene expression alterations in human tissues) Tag: New redirect
- 07:42, 10 December 2023 Dmitry Dzhagarov talk contribs created page PAI-1 gene (Created page with "'''PAI-1 (Plasminogen activator inhibitor-1)''', also known as endothelial plasminogen activator inhibitor ('''serpin E1''') is a protein that in humans is encoded by the SERPINE1 gene. PAI-1 is a key component of the SASP and a direct mediator of cellular senescence.<ref>Eren, M., Boe, A. E., Murphy, S. B., Place, A. T., Nagpal, V., Morales-Nebreda, L., ... & Vaughan, D. E. (2014). PAI-1–regulated extracellular proteolysis governs senescence and survival in Klotho mi...")
- 01:09, 9 December 2023 Dmitry Dzhagarov talk contribs created page Biolearn, an open-source library for biomarkers of aging (Redirected page to Human Ageing Genomic Resources#Biolearn, an open-source library for biomarkers of aging) Tag: New redirect
- 01:01, 9 December 2023 Dmitry Dzhagarov talk contribs created page DrugAge (Redirected page to Human Ageing Genomic Resources#DrugAge) Tag: New redirect
- 00:54, 9 December 2023 Dmitry Dzhagarov talk contribs created page HALL: a comprehensive database for human aging and longevity studies (Redirected page to Human Ageing Genomic Resources#HALL: a comprehensive database for human aging and longevity studies) Tag: New redirect
- 09:52, 8 December 2023 Dmitry Dzhagarov talk contribs created page Geroprotectors (Created page with "'''Geroprotectors''' are substances that slow down aging process and can be used as senotherapeutics for prevention of age-related diseases.<ref>Moskalev, A. A. (2023). Potential Geroprotectors–From Bench to Clinic. Biochemistry (Moscow), 88(11), 1732-1738. https://doi.org/10.1134/S0006297923110056</ref><ref>Janssens, G. E., & Houtkooper, R. H. (2020). Identification of longevity compounds with minimized probabilities of side effects. Biogerontology, 21(6), 709-719. PM...")
- 08:52, 7 December 2023 Dmitry Dzhagarov talk contribs created page Category:Database (Created page with "'''Database'''") Tag: Visual edit: Switched
- 19:30, 2 December 2023 Dmitry Dzhagarov talk contribs created page Human Ageing Genomic Resources (Created page with "'''The Human Ageing Genomic Resources (HAGR)''' is a collection of databases and tools designed to help researchers study the genetics of human ageing using modern approaches such as functional genomics, network analyses, systems biology and evolutionary analyses.<ref>[https://genomics.senescence.info Human Ageing Genomic Resources]</ref> == GenAge == A major resource in HAGR is GenAge,<ref>[https://genomics.senescence.info/genes/index.html GenAge Database of Ageing-Rel...")
- 03:51, 1 December 2023 Dmitry Dzhagarov talk contribs created page LOY-001 (Created page with "'''LOY-001''' is the long-acting drug intended to extend lifespan and healthspan for large and giant breed dogs.<ref> A San Francisco-based biotech & veterinary medicine firm Loyal (November 28, 2023) [https://loyalfordogs.com/posts/loyal-announces-historic-fda-milestone-for-large-dog-lifespan-extension-drug FDA Center for Veterinary Medicine agrees Loyal’s data supports reasonable expectation of effectiveness for large dog lifespan extension]</...")
- 17:32, 29 November 2023 Dmitry Dzhagarov talk contribs created page File:Age reprogramming.jpg
- 17:32, 29 November 2023 Dmitry Dzhagarov talk contribs uploaded File:Age reprogramming.jpg
- 08:58, 25 November 2023 Dmitry Dzhagarov talk contribs created page SLIT2 (Created page with "'''SLIT2''' (Slit Guidance Ligand 2) is a protein coding gene that encode large secreted protein functioning as ligand for '''Roundabout (Robo)''' receptors.<ref>Blockus, H., & Chédotal, A. (2016). Slit-robo signaling. Development, 143(17), 3037-3044. PMID: 27578174 DOI: 10.1242/dev.132829</ref><ref>Wu, M. F., Liao, C. Y., Wang, L. Y., & Chang, J. T. (2017). The role of Slit-Robo signaling in the regulation of tissue barriers. Tissue Barriers, 5(2), e1331155. PMID: 285...")
- 11:25, 15 November 2023 Dmitry Dzhagarov talk contribs created page File:Mitophagy Inducing Coumarin (MIC).jpg
- 11:25, 15 November 2023 Dmitry Dzhagarov talk contribs uploaded File:Mitophagy Inducing Coumarin (MIC).jpg
- 10:55, 15 November 2023 Dmitry Dzhagarov talk contribs created page Mitophagy Inducing Coumarin (MIC) (Created page with "'''Mitophagy Inducing Coumarin (MIC)''' is a benzocoumarin-based compound present in a high level in many edible plants and vegetables, which is capable of displaying a significant dose-dependent increase in TFEB (Transcription factor EB is a master gene for lysosomal biogenesis) promoter activity. MIC induces mitophagy and suppresses mitochondrial dysfunction, a major hallmark of aging, in both C. elegans and mammalian cell culture models.<ref>Chamoli, M., Rane, A., Fou...")
- 12:50, 14 November 2023 Dmitry Dzhagarov talk contribs created page Lepodisiran (Created page with "'''Lepodisiran''' is a small interfering RNA (siRNA) that disables messenger RNA involved in producing apolipoprotein(a), a component essential for the assembly of lipoprotein(a) (Lp(a)) particles that is synthesized in the liver. The drug is a Dicer substrate short interfering RNA with a tetraloop structure attached to the sugar N-Acetylgalactosamine (GalNAc), which allows it to be carried into liver cells possessing GalNAc receptors. <ref name="Short" >Nissen SE, Linne...")
- 08:38, 13 November 2023 Dmitry Dzhagarov talk contribs created page Dietary supplement against atherosclerosis (Created page with "A scientifically proven dietary supplement that will allow people with initial forms of atherosclerosis to prolong their lives: 1. ß-cyclodextrin (a cheap prophylactic agent that reduces blood cholesterol levels); 2. acarbose (a prophylactic agent that reduces blood glucose levels); 3. homogenate of 2-3 week old red cabbage sprouts (contains sulforaphane, tocopherols and flavones); 4. celery homogenate (contains apigenin - protects NAD+, quercetin - senolytic); resverat...")
- 20:19, 10 November 2023 Dmitry Dzhagarov talk contribs created page File:Pentadecanoic acid (C15-0).jpg
- 20:19, 10 November 2023 Dmitry Dzhagarov talk contribs uploaded File:Pentadecanoic acid (C15-0).jpg
- 19:11, 10 November 2023 Dmitry Dzhagarov talk contribs created page Pentadecanoic Acid (C15: 0) (Created page with "'''Pentadecanoic Acid (C15: 0)''', also known as '''pentadecylic acid''', is a fatty acid, like omega-3 and omega-6, but unlike them, pentadecanoic acid (C15: 0) has no double bonds in its main chain, making it a resilient molecule that is resistant to oxidation.<ref name="resistant" >Venn-Watson, S. K., & Butterworth, C. N. (2022). Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid a...")
- 20:06, 7 November 2023 Dmitry Dzhagarov talk contribs created page Why does green tea seem to improve longevity? (Created page with "'''Green tea''' comes from the plant ''Camellia sinensis'', and is made from unfermented leaves. Freshly harvested tea leaves are immediately steamed to prevent fermentation and destroy enzymes.<ref>Ali, R. B., & Almokhtar, M. N. (2023). Camellia Sinensis (Green Tea) Health Benefits. Journal of Medical Sciences, 18(2), 1-7. https://doi.org/10.51984/joms.v18i2.2784</ref> This helps to preserve the natural polyphenols in green tea, which contribute to many health-promoting...")