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12:59, 1 September 2024 Dmitry Dzhagarov talk contribs created page Preventing muscle loss (Created page with "'''Preventing muscle loss''' Skeletal muscle atrophy is characterized by weakening, shrinking, and decreasing muscle mass and fiber cross-sectional area at the histological level. It manifests as a reduction in force production, easy fatigue and decreased exercise capability, along with a lower quality of life. '''Exercise''' is widely acknowledged as '''the most effective therapy for skeletal muscle atrophy'''; unfortunately, it is not applicable for all patients. Sev...")
19:21, 25 August 2024 Dmitry Dzhagarov talk contribs created page Granzyme B (Created page with "'''Granzymes''', a family of serine proteases with intracellular cytotoxic and/or proinflammatory functions, are increasingly recognized for their emerging roles in biological aging and disease. Widely recognized as intracellular mediators of cell death, granzymes, particularly '''granzyme B (GzmB)''' is observed in numerous age-related conditions, also accumulate in the extracellular milieu of tissues with age, contributing to chronic tissue injury, inflammation, and i...")
15:41, 18 August 2024 User account HerbertAmey366 talk contribs was created
17:39, 15 August 2024 Dmitry Dzhagarov talk contribs created page Seno-protective benefits of tropoelastin (Created page with "Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.<ref>Shek, N., Choy, A. M., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., ... & Huang, J. T. (2024). Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. npj Aging, 10(1), 15. PMID: 38413600 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10899634/ PMC10899634] DOI: 10.1038/s41514-024-00143-7</ref> "... Ultra-...")
14:02, 12 August 2024 User account MerrillKnowles0 talk contribs was created
11:45, 19 July 2024 Dmitry Dzhagarov talk contribs created page PEPITEM (Created page with "PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration) is a B cell-secreted peptide which inhibits T cell trafficking across cytokine-stimulated endothelium. This homeostatic mechanism is lost in autoimmune and chronic inflammatory diseases, leading to inappropriate T cell trafficking with pathological consequences, e.g. in type-1 diabetes and rheumatoid arthritis.<ref>Chimen, M., McGettrick, H. M., Apta, B., Kuravi, S. J., Yates, C. M., Kennedy, A., ... & Rainger, G...")
19:40, 17 July 2024 Dmitry Dzhagarov talk contribs created page PRC2-AgeIndex (Created page with "'''PRC2-AgeIndex''' is the average DNA methylation (DNAm) in Polycomb Repressive Complex 2 (PRC2) low-methylated regions (LMRs) which are highly bound by PRC2.<ref name="universal" >Moqri, M., Cipriano, A., Simpson, D.J. et al. (2024). PRC2-AgeIndex as a universal biomarker of aging and rejuvenation. Nat Commun 15, 5956 https://doi.org/10.1038/s41467-024-50098-2</ref> PRC2-AgeIndex is a universal biomarker of cellular aging in somatic cells.<ref name="universal" /> [...")
06:46, 17 July 2024 Dmitry Dzhagarov talk contribs created page Nicotinamide N-methyltransferase inhibitors (NNMTis) (Created page with "'''Nicotinamide N-methyltransferase inhibitors (NNMTis)''' treatment could surpass the muscle health benefits of resistance and endurance exercise. NNMTi treatment prevents age-associated loss of strength and actively rebuilds strength. Moreover, NNMTi treatment almost doubled the increase in muscle strength compared to exercise alone. The increases in muscle strength resulting from NNMTi treatment or exercise were additive, with the strength of the NNMTi-treated exercis...")
19:53, 16 July 2024 Dmitry Dzhagarov talk contribs created page Inflammaging protein markers (Created page with "Some inflammatory protein markers, especially '''CXCL9''' (Chemokine (C-X-C motif) ligand 9) and '''OPG''' (Osteoprotegerin), could distinguish long-living and elderly correctly which could be used to predict lifespan combined with other anti-aging markers.<ref>Jie Liu, Qifu Zhu, Dan Zhang, Qihui Yu, Xin Zheng, Shuihong Yao, and Xinhua Wang (2024) Exploring the expression profiles of serum inflammatory proteins and potential anti-aging targets in Chinese long-living peop...")
20:36, 10 July 2024 Dmitry Dzhagarov talk contribs created page GDF5 (Growth differentiation factor 5) (Created page with "'''GDF5 (Growth differentiation factor 5)''' leads to a “rejuvenating” transcriptomic signature in aged mice, as 42% of the transcripts dysregulated by ageing reverted to youthful expression levels and (17,8% of absolute maximal force increase) upon treating chronically (for 4 months) aged mice using recombinant GDF5 protein (rGDF5) in systemic administration.<ref>Massiré, T., Chiara, N., Amélie, V., Christel, G., Marius, H., Lucile, S., ... & Sestina, F. (2024). G...")
08:10, 27 June 2024 Dmitry Dzhagarov talk contribs created page TERT activator compound (TAC) (Created page with "'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of TERT in both human and mouse somatic tissues.<ref>Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref> Category:Drugs Category:Stub")
02:36, 26 June 2024 User account SilkeStidham talk contribs was created
14:30, 25 June 2024 User account JanLamington7 talk contribs was created
18:30, 21 June 2024 User account MaddisonJimenez talk contribs was created
16:18, 19 June 2024 Dmitry Dzhagarov talk contribs created page MTOR (Created page with "'''mTOR''' (The mammalian target of rapamycin) is a protein kinase that plays an important role in regulating metabolism, cell growth and survival, immunity, and aging in response to different stimuli such as hormones, growth factors, nutrients, and stress signals.<ref>Review by Marafie SK, Al-Mulla F, Abubaker J. (2024). mTOR: Its Critical Role in Metabolic Diseases, Cancer, and the Aging Process. International Journal of Molecular Sciences. 25(11), 6141. https://do...")
02:21, 19 June 2024 User account Isabell65G talk contribs was created
16:09, 16 June 2024 User account EveSomers8263 talk contribs was created
04:46, 11 June 2024 User account DakotaMorshead talk contribs was created
20:57, 10 June 2024 Dmitry Dzhagarov talk contribs created page Calcium channel blockers (CCBs) (Created page with "'''Calcium channel blockers (CCBs)''' use was associated with a 70% lower risk for frailty (95%CI = 0.09 to 0.77).<ref>Chuang, S. Y., Pan, W. H., Chang, H. Y., Wu, C. I., Chen, C. Y., & Hsu, C. C. (2016). Protective effect of calcium channel blockers against frailty in older adults with hypertension. Journal of the American Geriatrics Society, 64(6), 1356-1358.</ref> The point estimates for calcium channel blockers (CCBs) indicated a decrease in seven DNAmAges (a decre...")
15:33, 6 June 2024 Dmitry Dzhagarov talk contribs created page Anti-aging strategies (Created page with "Li, Y., Tian, X., Luo, J. et al. [https://link.springer.com/article/10.1186/s12964-024-01663-1#citeas Molecular mechanisms of aging and anti-aging strategies]. Cell Commun Signal 22, 285 (2024). https://doi.org/10.1186/s12964-024-01663-1 Category:Lifespan interventions")
19:07, 31 May 2024 Dmitry Dzhagarov talk contribs created page Questionnaire-based biological age clock (Created page with "The biological age test is powered by ENABL Age, an algorithm and epigenetic clock built by longevity experts. The algorithm combines machine learning models with explainable artificial intelligence (XAI) methods to produce accurate biological age outputs and predict age-related outcomes based on lifestyle and health behaviours. Users can access the Novos Life test by completing a lifestyle survey upon signing up for the app. The app also provides an actionable longevit...")
16:03, 29 May 2024 Dmitry Dzhagarov talk contribs created page ExplaiNAble BioLogical Age (ENABL Age) (Created page with "'''ExplaiNAble BioLogical Age (ENABL Age)''' <ref>Qiu, W., Chen, H., Kaeberlein, M., & Lee, S. I. (2023). ExplaiNAble BioLogical Age (ENABL Age): an artificial intelligence framework for interpretable biological age. The Lancet Healthy Longevity, 4(12), e711-e723. PMID: 37944549 [https://doi.org/10.1016/S2666-7568(23)00189-7 DOI: 10.1016/S2666-7568(23)00189-7]</ref> Category:Longevity concepts Category:Tools to study aging")
17:52, 25 May 2024 User account DannY5493835 talk contribs was created
18:50, 23 May 2024 Dmitry Dzhagarov talk contribs created page Aging odor (加齢臭) (Created page with "'''Aging odor (加齢臭)''' in the elderly are often associated with the aging body itself. The main causative agent of this “aging odor” is sweat and sebum, with the point of origin is believed to be the sebum glands and hair glands, based on the odor’s characteristics.")
12:33, 7 May 2024 Dmitry Dzhagarov talk contribs created page Ovaltine (Created page with "'''Ovaltine''' — a milk flavoring and nutrition supplement. Ovaltine (also known by its original name Ovomaltine (from ovum, Latin for "egg", and malt, which were originally its key ingredients)) is a brand of milk flavoring product made with '''malt extract''', '''eggs''', '''cocoa''' and '''whey'''. The 110 years old, supercentenarian Vincent Dransfield credits drinking Ovaltine every day after breakfast for his longevity.<ref>PAWLOWSKI A.(2024). Man, 110, who still...")
10:12, 7 May 2024 Dmitry Dzhagarov talk contribs created page Healthy Aging Metabolic (HAM) Index (Created page with "'''Healthy Aging Metabolic (HAM) Index''' See: <ref>Hamsanathan, S., Anthonymuthu, T., Prosser, D., Lokshin, A., Greenspan, S. L., Resnick, N. M., ... & Gurkar, A. U. (2024). A molecular index for biological age identified from the metabolome and senescence‐associated secretome in humans. Aging Cell, 23(4), e14104. https://doi.org/10.1111/acel.14104</ref> Category:Aging pathways and hallmarks Category:Stub Category:Tools to study aging Category:Main...")
18:59, 6 May 2024 Dmitry Dzhagarov talk contribs created page Pigment epithelium-derived factor (PEDF) (Created page with "'''Pigment epithelium-derived factor (PEDF)''' is a 50 kDa secreted glycoprotein that belongs to the non-inhibitory group of the serine protease inhibitor (SERPIN) superfamily.<ref>Filleur, S., Nelius, T. I. O. V. S., De Riese, W., & Kennedy, R. C. (2009). Characterization of PEDF: a multi‐functional serpin family protein. Journal of cellular biochemistry, 106(5), 769-775. https://doi.org/10.1002/jcb.22072</ref> PEDF plays an important role in mediating cellular protec...")
19:36, 7 April 2024 Dmitry Dzhagarov talk contribs created page Secretome treatment (Created page with "Back in 1980, it was demonstrated that when cells are cultured, they release various proteins into the culture medium, which can affect the phenotype of other cells that enter this environment.<ref>Todaro, G. J., Fryling, C., & De Larco, J. E. (1980). Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors. Proceedings of the National Academy of Sciences, 77(9), 5258-5262. PMID: 6254071 PMC35003...")
18:26, 1 April 2024 Dmitry Dzhagarov talk contribs created page Six major anti-aging drugs and their related signal pathways (Redirected page to Six major anti-aging drugs and their related signal pathways,) Tags: New redirect Visual edit: Switched
12:34, 25 March 2024 Dmitry Dzhagarov talk contribs created page Small nucleoli as a visible cellular hallmark of longevity and metabolic health (Created page with "The nucleolus is a nuclear subcompartment where ribosomal RNA is synthesized and assembled into ribosomal subunits. It is a dynamic organelle subject to inputs from growth signalling pathways, nutrients, and stress, whose size correlates with rRNA synthesis.<ref>Boulon, S., Westman, B. J., Hutten, S., Boisvert, F. M., & Lamond, A. I. (2010). The nucleolus under stress. Molecular cell, 40(2), 216-227. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987465/ PMC2987465/] doi...")
23:17, 24 March 2024 User account Jesper2k talk contribs was created
10:19, 22 March 2024 Dmitry Dzhagarov talk contribs created page Ubiquitin Ligase WWP2 (Created page with "WWP2 (WW domain containing E3 ubiquitin-protein ligase 2) is an enzyme that contains 4 tandem WW (double-tryptophan) domains, named after the presence of two conserved tryptophans (W).<ref>Chen, W., Jiang, X., & Luo, Z. (2014). WWP2: a multifunctional ubiquitin ligase gene. Pathology & Oncology Research, 20, 799-803. [https://pubmed.ncbi.nlm.nih.gov/25216927/ PMID: 25216927] DOI: 10.1007/s12253-014-9838-y</ref><ref>You, S., Xu, J., Guo, Y., Guo, X., Zhang, Y., Zhang, N.,...")
17:24, 17 March 2024 Dmitry Dzhagarov talk contribs created page Squalene (Created page with "'''Squalene''' is a polyunsaturated triterpenoid compound with the formula C30H50 present as biochemical precursor in sterol biosynthesis, including cholesterol and steroid hormones in various organisms.<ref>Micera, M., Botto, A., Geddo, F., Antoniotti, S., Bertea, C. M., Levi, R., ... & Querio, G. (2020). Squalene: More than a step toward sterols. Antioxidants, 9(8), 688. PMID: 32748847 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464659/ PMC7464...")
09:56, 17 March 2024 Dmitry Dzhagarov talk contribs created page Savior sibling technology for rejuvenation (Created page with "'''Savior sibling technology for rejuvenation''' was originally developed in 2004 by Anver Kuliev & Yury Verlinsky.<ref>Kuliev A. & Verlinsky Y. (2004). Preimplantation HLA typing and stem cell transplantation: report of International Meeting, Cyprus, 27–28 March, PMID: 15354311 [https://www.rbmojournal.com/article/S1472-6483(10)62131-1/pdf DOI: 10.1016/s1472-6483(10)62131-1]</ref><ref>Kuliev, A., Rechitsky, S., TUR‐KASPA, I. L. A. N., & Verlinsky, Y. (2005). Preimpl...")
20:19, 4 March 2024 Dmitry Dzhagarov talk contribs created page Age-related hearing loss (Created page with "'''Age-related hearing loss (or presbycusis)''' is the gradual loss of hearing in both ears. It's a common problem linked to aging. Presbycusis is a complex multidimensional disorder, in addition to aging, multiple factors including exposure to noise, or ototoxic agents, genetic susceptibility, metabolic diseases and lifestyle can influence the onset and severity of presbycusis. Nevertheless, among this variety of factors involved in hearing loss, aging is one of the mos...")
16:40, 27 February 2024 User account BuyDofollowblogcomments talk contribs was created
19:14, 22 February 2024 Dmitry Dzhagarov talk contribs created page TUDCA (tauroursodeoxycholic acid) (Created page with "'''TUDCA (tauroursodeoxycholic acid)''' is a taurine conjugate of ursodeoxycholic acid (UDCA) with chemical chaperone activity.<ref>Chen, Y., Liu, C. P., Xu, K. F., Mao, X. D., Lu, Y. B., Fang, L., ... & Liu, C. (2008). Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes. American journal of nephrology, 28(6), 1014-1022.</ref> TUDCA is a minor component of h...") Tag: Visual edit: Switched
09:07, 22 February 2024 Dmitry Dzhagarov talk contribs created page Aging-related epigenetic changes (Created page with "Epigenetics, a rapidly evolving field, refers to the study of modifications to gene expression that does not alter the DNA sequence. Epigenetic dysregulation is both a hallmark and a driver of aging and restoring epigenetic integrity can reverse aging phenotypes.<ref>Pereira, B., Correia, F. P., Alves, I. A., Costa, M., Gameiro, M., Martins, A. P., & Saraiva, J. A. (2024). Epigenetic Reprogramming as a Key to Reverse Ageing and Increase Longevity. Ageing Research Reviews...")
18:54, 16 February 2024 Dmitry Dzhagarov talk contribs created page GV1001 (Created page with "Redirect")
08:59, 10 February 2024 Dmitry Dzhagarov talk contribs created page KEEY - Longevity Supplement (Created page with "[https://shop.extensia.life/products/keey? '''KEEY'''] is the longevity supplement, formulated with 10 scientifically backed ingredients in every pill: *. '''Nicotinamide Mononucleotide (NMN)''': Key in enhancing lifespan and energy output. - 260 mg *. '''D-Glucosamine Hydrochloride''': Promotes skin health by boosting collagen levels, leading to reduced wrinkles and visible signs of aging. - 480 mg *. '''Spermidine 3HCl''': Linked to extending lifespan by up to 30% i...")
09:34, 9 February 2024 Dmitry Dzhagarov talk contribs created page Intrinsic capacity (Created page with "'''Intrinsic capacity''' is a composite of five domains that summarizes the physical and mental capacities of an individual: '''sensorial, cognition, nutrition, mobility,''' and '''psychological''' as defined by the World Health Organization.<ref>Zhou, Y., & Ma, L. (2022). Intrinsic capacity in older adults: recent advances. Aging and disease, 13(2), 353. PMID: 35371613 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947834/ PMC8947834] DOI: 10.14336/AD.2021.0818</ref><re...")
08:11, 7 February 2024 Dmitry Dzhagarov talk contribs created page Rejuvant (Created page with "'''Rejuvant®''', an alpha-ketoglutarate based formulation that was found to extend lifespan and delay the onset of age-associated decline in experimental models such as nematodes, fruit flies, yeasts, and mice.<ref>Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer III, F. R., Kennedy, B. K., & Budovskaya, Y. V. (2021). Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction...")
18:52, 3 February 2024 Dmitry Dzhagarov talk contribs created page Minoxidil (Created page with "'''Minoxidil''' is a potassium channel opener vasodilator.<ref>Nawar, T., Nolin, L., Plante, G. E., Caron, C., & Montambault, P. (1977). Long-term treatment of severe hypertension with minoxidil. Canadian Medical Association Journal, 117(10), 1178. PMID: 603847 PMC1880293</ref><ref>Campese, V. M. (1981). Minoxidil: a review of its pharmacological properties and therapeutic use. Drugs, 22, 257-278. https://doi.org/10.2165/00003495-198122040-00001</ref><ref>Gupta, A. K.,...") Tag: Visual edit: Switched
15:44, 22 January 2024 Dmitry Dzhagarov talk contribs created page File:Super-enhancer-associated oncogenes.jpg
15:44, 22 January 2024 Dmitry Dzhagarov talk contribs uploaded File:Super-enhancer-associated oncogenes.jpg
07:13, 13 January 2024 Dmitry Dzhagarov talk contribs created page Six major anti-aging drugs and their related signal pathways, (Created page with "Six major anti-aging drugs and their related signal pathways (with 6 circuit illustrations) according to Nannan Du et al. and Qiang Sun:<ref>Du, N., Yang, R., Jiang, S., Niu, Z., Zhou, W., Liu, C., ... & Sun, Q. (2024). Anti-Aging Drugs and the Related Signal Pathways. Biomedicines, 12(1), 127. https://doi.org/10.3390/biomedicines12010127</ref> #. '''Rapamycin''' and the Aging-Related '''mTOR''' Signal Pathway #. '''Metformin''' and the Aging-Related '''AMPK'''...")
11:42, 12 January 2024 Dmitry Dzhagarov talk contribs created page Body mass index (BMI) (Created page with "'''Body mass index (BMI)''' is defined as the body mass divided by the square of the body height, and is expressed in units of kg/m2, resulting from mass in kilograms (kg) and height in metres (m). The BMI is expressed in kg/m2, resulting from mass in kilograms and height in metres. If pounds and inches are used, a conversion factor of 703 (kg/m2)/(lb/in2) is applied. BMI = masskg/heightm2 = 703 x masslb/...")
08:00, 11 January 2024 Dmitry Dzhagarov talk contribs created page G-quadruplex (G4)-driven epigenomic aging (Created page with " <ref>Sen D, Gilbert W (1988). Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis. Nature. 334 (6180): 364–6. Bibcode:1988Natur.334..364S. doi:10.1038/334364a0. PMID 3393228</ref> <ref>Routh ED, Creacy SD, Beerbower PE, Akman SA, Vaughn JP, Smaldino PJ (2017). A G-quadruplex DNA-affinity Approach for Purification of Enzymaticacvly Active G4 Resolvase1. Journal of Visualized Experiments. 121 (121). doi:10.3791/5...")
06:43, 5 January 2024 Dmitry Dzhagarov talk contribs created page Isofalcarintriol (Created page with "{| class="wikitable" |- ! Isofalcarintriol |- | thumb |- | Formula C17H26O3 |- | Molecular Weight 278.39 |} '''Isofalcarintriol''' ((3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol) is a polyacetylene contained in the root of carrots (Daucus carota), which was revealed as potent promoter of longevity in the nematode ''C. elegans'' even at remarkably low doses.<ref name="carrots" >Thomas, C., Erni,...")
06:27, 5 January 2024 Dmitry Dzhagarov talk contribs created page File:Isofalcarintriol.jpg