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10:34, 21 September 2024 ‎Role of JNK in aging (hist | edit) ‎[1,811 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''JNK (c-Jun N-terminal kinase)''' is a crucial signaling pathway that plays a significant role in normal physiological processes. The JNK signaling pathway exhibits a dual nature during the aging process. For instance, when JNK is activated in the brain, it leads to a prolonged lifespan, whereas moderate activation of JNK in midgut intestinal stem cells (ISCs) and enteroblasts significantly shortens lifespan.<ref>Gan, T., Fan, L., Zhao, L., Misra, M., Liu, M., Zhang, M...")
18:57, 13 September 2024 ‎OSER1 gene (hist | edit) ‎[930 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''OSER1 (Oxidative stress-responsive serine-rich protein 1)''' is an evolutionarily conserved '''FOXO-regulated protein''' that improves resistance to oxidative stress, maintains mitochondrial functional integrity, and increases lifespan in multiple species. OSER1 overexpression extends lifespan in silkworms, nematodes, and flies, while its depletion correspondingly shortens lifespan. Human proteomic analysis suggests that OSER1 plays roles in o...")
12:59, 1 September 2024 ‎Preventing muscle loss (hist | edit) ‎[5,152 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''Preventing muscle loss''' Skeletal muscle atrophy is characterized by weakening, shrinking, and decreasing muscle mass and fiber cross-sectional area at the histological level. It manifests as a reduction in force production, easy fatigue and decreased exercise capability, along with a lower quality of life. '''Exercise''' is widely acknowledged as '''the most effective therapy for skeletal muscle atrophy'''; unfortunately, it is not applicable for all patients. Sev...")
19:21, 25 August 2024 ‎Granzyme B (hist | edit) ‎[1,413 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''Granzymes''', a family of serine proteases with intracellular cytotoxic and/or proinflammatory functions, are increasingly recognized for their emerging roles in biological aging and disease. Widely recognized as intracellular mediators of cell death, granzymes, particularly '''granzyme B (GzmB)''' is observed in numerous age-related conditions, also accumulate in the extracellular milieu of tissues with age, contributing to chronic tissue injury, inflammation, and i...")
17:39, 15 August 2024 ‎Seno-protective benefits of tropoelastin (hist | edit) ‎[2,170 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.<ref>Shek, N., Choy, A. M., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., ... & Huang, J. T. (2024). Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. npj Aging, 10(1), 15. PMID: 38413600 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10899634/ PMC10899634] DOI: 10.1038/s41514-024-00143-7</ref> "... Ultra-...")
11:45, 19 July 2024 ‎PEPITEM (hist | edit) ‎[2,873 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration) is a B cell-secreted peptide which inhibits T cell trafficking across cytokine-stimulated endothelium. This homeostatic mechanism is lost in autoimmune and chronic inflammatory diseases, leading to inappropriate T cell trafficking with pathological consequences, e.g. in type-1 diabetes and rheumatoid arthritis.<ref>Chimen, M., McGettrick, H. M., Apta, B., Kuravi, S. J., Yates, C. M., Kennedy, A., ... & Rainger, G...")
19:40, 17 July 2024 ‎PRC2-AgeIndex (hist | edit) ‎[571 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''PRC2-AgeIndex''' is the average DNA methylation (DNAm) in Polycomb Repressive Complex 2 (PRC2) low-methylated regions (LMRs) which are highly bound by PRC2.<ref name="universal" >Moqri, M., Cipriano, A., Simpson, D.J. et al. (2024). PRC2-AgeIndex as a universal biomarker of aging and rejuvenation. Nat Commun 15, 5956 https://doi.org/10.1038/s41467-024-50098-2</ref> PRC2-AgeIndex is a universal biomarker of cellular aging in somatic cells.<ref name="universal" /> [...")
06:46, 17 July 2024 ‎Nicotinamide N-methyltransferase inhibitors (NNMTis) (hist | edit) ‎[1,317 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''Nicotinamide N-methyltransferase inhibitors (NNMTis)''' treatment could surpass the muscle health benefits of resistance and endurance exercise. NNMTi treatment prevents age-associated loss of strength and actively rebuilds strength. Moreover, NNMTi treatment almost doubled the increase in muscle strength compared to exercise alone. The increases in muscle strength resulting from NNMTi treatment or exercise were additive, with the strength of the NNMTi-treated exercis...")
19:53, 16 July 2024 ‎Inflammaging protein markers (hist | edit) ‎[2,965 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "Some inflammatory protein markers, especially '''CXCL9''' (Chemokine (C-X-C motif) ligand 9) and '''OPG''' (Osteoprotegerin), could distinguish long-living and elderly correctly which could be used to predict lifespan combined with other anti-aging markers.<ref>Jie Liu, Qifu Zhu, Dan Zhang, Qihui Yu, Xin Zheng, Shuihong Yao, and Xinhua Wang (2024) Exploring the expression profiles of serum inflammatory proteins and potential anti-aging targets in Chinese long-living peop...")
20:36, 10 July 2024 ‎GDF5 (Growth differentiation factor 5) (hist | edit) ‎[647 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''GDF5 (Growth differentiation factor 5)''' leads to a “rejuvenating” transcriptomic signature in aged mice, as 42% of the transcripts dysregulated by ageing reverted to youthful expression levels and (17,8% of absolute maximal force increase) upon treating chronically (for 4 months) aged mice using recombinant GDF5 protein (rGDF5) in systemic administration.<ref>Massiré, T., Chiara, N., Amélie, V., Christel, G., Marius, H., Lucile, S., ... & Sestina, F. (2024). G...")
08:10, 27 June 2024 ‎TERT activator compound (TAC) (hist | edit) ‎[3,889 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''TERT activator compound (TAC)''' - a novel small-molecule telomerase activator that induces the physiological expression of TERT in both human and mouse somatic tissues.<ref>Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048</ref> Category:Drugs Category:Stub")
16:18, 19 June 2024 ‎MTOR (hist | edit) ‎[602 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''mTOR''' (The mammalian target of rapamycin) is a protein kinase that plays an important role in regulating metabolism, cell growth and survival, immunity, and aging in response to different stimuli such as hormones, growth factors, nutrients, and stress signals.<ref>Review by Marafie SK, Al-Mulla F, Abubaker J. (2024). mTOR: Its Critical Role in Metabolic Diseases, Cancer, and the Aging Process. International Journal of Molecular Sciences. 25(11), 6141. https://do...")