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  • 19:36, 7 April 2024 ‎Secretome treatment (hist | edit) ‎[3,132 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "Back in 1980, it was demonstrated that when cells are cultured, they release various proteins into the culture medium, which can affect the phenotype of other cells that enter this environment.<ref>Todaro, G. J., Fryling, C., & De Larco, J. E. (1980). Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors. Proceedings of the National Academy of Sciences, 77(9), 5258-5262. PMID: 6254071 PMC35003...")
  • 12:34, 25 March 2024 ‎Small nucleoli as a visible cellular hallmark of longevity and metabolic health (hist | edit) ‎[11,518 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "The nucleolus is a nuclear subcompartment where ribosomal RNA is synthesized and assembled into ribosomal subunits. It is a dynamic organelle subject to inputs from growth signalling pathways, nutrients, and stress, whose size correlates with rRNA synthesis.<ref>Boulon, S., Westman, B. J., Hutten, S., Boisvert, F. M., & Lamond, A. I. (2010). The nucleolus under stress. Molecular cell, 40(2), 216-227. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987465/ PMC2987465/] doi...")
  • 10:19, 22 March 2024 ‎Ubiquitin Ligase WWP2 (hist | edit) ‎[2,787 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "WWP2 (WW domain containing E3 ubiquitin-protein ligase 2) is an enzyme that contains 4 tandem WW (double-tryptophan) domains, named after the presence of two conserved tryptophans (W).<ref>Chen, W., Jiang, X., & Luo, Z. (2014). WWP2: a multifunctional ubiquitin ligase gene. Pathology & Oncology Research, 20, 799-803. [https://pubmed.ncbi.nlm.nih.gov/25216927/ PMID: 25216927] DOI: 10.1007/s12253-014-9838-y</ref><ref>You, S., Xu, J., Guo, Y., Guo, X., Zhang, Y., Zhang, N.,...")
  • 17:24, 17 March 2024 ‎Squalene (hist | edit) ‎[2,729 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''Squalene''' is a polyunsaturated triterpenoid compound with the formula C<sub>30</sub>H<sub>50</sub> present as biochemical precursor in sterol biosynthesis, including cholesterol and steroid hormones in various organisms.<ref>Micera, M., Botto, A., Geddo, F., Antoniotti, S., Bertea, C. M., Levi, R., ... & Querio, G. (2020). Squalene: More than a step toward sterols. Antioxidants, 9(8), 688. PMID: 32748847 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464659/ PMC7464...")
  • 09:56, 17 March 2024 ‎Savior sibling technology for rejuvenation (hist | edit) ‎[2,553 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''Savior sibling technology for rejuvenation''' was originally developed in 2004 by Anver Kuliev & Yury Verlinsky.<ref>Kuliev A. & Verlinsky Y. (2004). Preimplantation HLA typing and stem cell transplantation: report of International Meeting, Cyprus, 27–28 March, PMID: 15354311 [https://www.rbmojournal.com/article/S1472-6483(10)62131-1/pdf DOI: 10.1016/s1472-6483(10)62131-1]</ref><ref>Kuliev, A., Rechitsky, S., TUR‐KASPA, I. L. A. N., & Verlinsky, Y. (2005). Preimpl...")
  • 20:19, 4 March 2024 ‎Age-related hearing loss (hist | edit) ‎[5,311 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''Age-related hearing loss (or presbycusis)''' is the gradual loss of hearing in both ears. It's a common problem linked to aging. Presbycusis is a complex multidimensional disorder, in addition to aging, multiple factors including exposure to noise, or ototoxic agents, genetic susceptibility, metabolic diseases and lifestyle can influence the onset and severity of presbycusis. Nevertheless, among this variety of factors involved in hearing loss, aging is one of the mos...")
  • 19:14, 22 February 2024 ‎TUDCA (tauroursodeoxycholic acid) (hist | edit) ‎[3,241 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''TUDCA (tauroursodeoxycholic acid)''' is a taurine conjugate of ursodeoxycholic acid (UDCA) with chemical chaperone activity.<ref>Chen, Y., Liu, C. P., Xu, K. F., Mao, X. D., Lu, Y. B., Fang, L., ... & Liu, C. (2008). Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes. American journal of nephrology, 28(6), 1014-1022.</ref> TUDCA is a minor component of h...") Tag: Visual edit: Switched
  • 09:07, 22 February 2024 ‎Aging-related epigenetic changes (hist | edit) ‎[8,422 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "Epigenetics, a rapidly evolving field, refers to the study of modifications to gene expression that does not alter the DNA sequence. Epigenetic dysregulation is both a hallmark and a driver of aging and restoring epigenetic integrity can reverse aging phenotypes.<ref>Pereira, B., Correia, F. P., Alves, I. A., Costa, M., Gameiro, M., Martins, A. P., & Saraiva, J. A. (2024). Epigenetic Reprogramming as a Key to Reverse Ageing and Increase Longevity. Ageing Research Reviews...")
  • 18:54, 16 February 2024 ‎GV1001 (hist | edit) ‎[29 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "Redirect")
  • 08:59, 10 February 2024 ‎KEEY - Longevity Supplement (hist | edit) ‎[1,701 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "[https://shop.extensia.life/products/keey? '''KEEY'''] is the longevity supplement, formulated with 10 scientifically backed ingredients in every pill: *. '''Nicotinamide Mononucleotide (NMN)''': Key in enhancing lifespan and energy output. - 260 mg *. '''D-Glucosamine Hydrochloride''': Promotes skin health by boosting collagen levels, leading to reduced wrinkles and visible signs of aging. - 480 mg *. '''Spermidine 3HCl''': Linked to extending lifespan by up to 30% i...")
  • 09:34, 9 February 2024 ‎Intrinsic capacity (hist | edit) ‎[2,645 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''Intrinsic capacity''' is a composite of five domains that summarizes the physical and mental capacities of an individual: '''sensorial, cognition, nutrition, mobility,''' and '''psychological''' as defined by the World Health Organization.<ref>Zhou, Y., & Ma, L. (2022). Intrinsic capacity in older adults: recent advances. Aging and disease, 13(2), 353. PMID: 35371613 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947834/ PMC8947834] DOI: 10.14336/AD.2021.0818</ref><re...")
  • 08:11, 7 February 2024 ‎Rejuvant (hist | edit) ‎[2,941 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''Rejuvant®''', an alpha-ketoglutarate based formulation that was found to extend lifespan and delay the onset of age-associated decline in experimental models such as nematodes, fruit flies, yeasts, and mice.<ref>Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer III, F. R., Kennedy, B. K., & Budovskaya, Y. V. (2021). Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction...")
  • 18:52, 3 February 2024 ‎Minoxidil (hist | edit) ‎[11,547 bytes] ‎Dmitry Dzhagarov (talk | contribs) (Created page with "'''Minoxidil''' is a potassium channel opener vasodilator.<ref>Nawar, T., Nolin, L., Plante, G. E., Caron, C., & Montambault, P. (1977). Long-term treatment of severe hypertension with minoxidil. Canadian Medical Association Journal, 117(10), 1178. PMID: 603847 PMC1880293</ref><ref>Campese, V. M. (1981). Minoxidil: a review of its pharmacological properties and therapeutic use. Drugs, 22, 257-278. https://doi.org/10.2165/00003495-198122040-00001</ref><ref>Gupta, A. K.,...") Tag: Visual edit: Switched
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