TERT activator compound (TAC)
| TERT activator compound (TAC) |
|---|
| Synonym: TAC-activator; TAC; TERT activator compound |
| CAS#: 666699-46-3 |
| IUPAC/Chemical Name: Benzenesulfonamide, N-(3-chloro-4-fluorophenyl)-4-fluoro-3,5-dimethyl |
| Chemical Formula: C14H12ClF2NO2S |
| Exact Mass: 331.02 |
| Molecular Weight: 331.762 |
TERT activator compound (TAC) - a novel small-molecule telomerase activator that induces the physiological expression of telomerase reverse transcriptase (TERT) in both human and mouse somatic tissues.[1][2][3]
Besides telomere extension, TERT exhibits other non-telomeric activities such as cell cycle regulation, modulation of cellular signaling and gene expression, augmentation of proliferative lifespan as well as the antioxidant defense and DNA damage responses.[4] Moreover, TERT participates in the mechanisms of cell competition.[5]
In experiments on aged mice, it was shown that TAC reaches numerous tissues and organs and reduces the signs of aging in them. By acting on the body's tissues, it significantly reduced age-related inflammation in tissues by reducing cellular senescence and inflammatory cytokines, improved neuromuscular function, coordination, grip strength and speed, stimulating neurogenesis and reversing sarcopenia.[1] In this case, the drug is eliminated from the body in about three hours. This was enough to improve numerous signs of aging. Chronic administration of TAC had a noticeable effect on the brain health and cognitive performance of mice without obvious toxicity or increased cancer risk.[1][6][7]
An enzyme called telomerase and related genes might be powerful targets for the treatment of age-related diseases such as cardiovascular, cognitive, neurodegenerative diseases, and cancer.[8]
References
- ↑ 1.0 1.1 1.2 Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., ... & DePinho, R. A. (2024). TERT activation targets DNA methylation and multiple aging hallmarks. Cell. https://doi.org/10.1016/j.cell.2024.05.048
- ↑ Marchal, I. (2024). Counteracting tissue aging through TERT activation. Nat Biotechnol 42, 1027 https://doi.org/10.1038/s41587-024-02327-8
- ↑ MedKoo Cat#: 556370 TERT activator compound (TAC)
- ↑ Marinaccio, J., Micheli, E., Udroiu, I., Di Nottia, M., Carrozzo, R., Baranzini, N., ... & Sgura, A. (2023). TERT extra-telomeric roles: antioxidant activity and mitochondrial protection. International Journal of Molecular Sciences, 24(5), 4450. PMID: 36901881 PMC10002448 DOI: 10.3390/ijms24054450
- ↑ Hasegawa, K., Zhao, Y., Garbuzov, A., Corces, M. R., Neuhöfer, P., Gillespie, V. M., ... & Artandi, S. E. (2024). Clonal inactivation of TERT impairs stem cell competition. Nature, 1-8. PMID: 39020172 DOI: 10.1038/s41586-024-07700-w
- ↑ Activating molecular target reverses multiple hallmarks of aging. MD Anderson Cancer Center.The University of Texas.
- ↑ Walters, H. Pharmacological TERT activation attenuates phenotypes of natural aging. Nature aging. PMID: 38977936 DOI: 10.1038/s43587-024-00673-5
- ↑ Aydin, Y., Orta-Yilmaz, B. (2023). The Role of Telomerase Activators in Antiaging Strategies and their Clinical Potential. In: Rizvi, S.I. (eds) Emerging Anti-Aging Strategies. Springer, Singapore. https://doi.org/10.1007/978-981-19-7443-4_12
