View source for TUDCA (tauroursodeoxycholic acid)

'''TUDCA (tauroursodeoxycholic acid)''' is a [[taurine]] conjugate of [[ursodeoxycholic acid (UDCA)]] with chemical chaperone activity.<ref>Chen, Y., Liu, C. P., Xu, K. F., Mao, X. D., Lu, Y. B., Fang, L., ... & Liu, C. (2008). Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes. American journal of nephrology, 28(6), 1014-1022.</ref> TUDCA is a minor component of human bile and a primary constituent of bear bile.<ref>Boatright, J. H., Moring, A. G., McElroy, C., Phillips, M. J., Do, V. T., Chang, B., ... & Pardue, M. T. (2006). Tool from ancient pharmacopoeia prevents vision loss. Mol Vis, 12, 1706-1714.</ref><ref>Huang, F., Mariani, N., Pariante, C. M., & Borsini, A. (2023). From dried bear bile to molecular investigation of differential effects of bile acids in ex vivo and in vitro models of myocardial dysfunction: Relevance for neuroinflammation. Brain, Behavior, & Immunity-Health, 100674.   PMID: 37593199 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430170/ PMC10430170] DOI: 10.1016/j.bbih.2023.100674</ref>  TUDCA attenuates ER stress in cardiomyocyte in models of obesity-associated cardiac dysfunction.

The gut microbiota generates ursodeoxycholic acid (UDCA), which then returns to the liver via enterohepatic circulation, where it conjugates with taurine to create TUDCA. TUDCA has been shown to improve the gut microbiota and reduce inflammation and barrier disruption in the intestines in animal studies. TUDCA has a wide range of health benefits, particularly for liver and aging health. It is believed to work by protecting liver cells from toxic bile acids, reducing inflammation, and regulating energy metabolism, which can enhance liver health. Additionally, TUDCA improves insulin sensitivity, which is essential for maintaining metabolic health and preventing diabetes.
Its potential to safeguard against age-related diseases makes it a promising candidate for future anti-aging therapies.<ref>Baba, B., Ceylani, T., Acikgoz, E., Gurbanov, R., Keskin, S., Samgane, G., ... & Teker, H. T. (2024). Promoting Longevity in Aged Liver through NLRP3 Inflammasome Inhibition Using Tauroursodeoxycholic Acid (TUDCA) and SCD Probiotics. bioRxiv, 2024-02. https://doi.org/10.1101/2024.02.27.582399</ref> <ref>Oveson, B. C., Iwase, T., Hackett, S. F., Lee, S. Y., Usui, S., Sedlak, T. W., ... & Sung, J. U. (2011). Constituents of bile, bilirubin and TUDCA, protect against oxidative stress‐induced retinal degeneration. Journal of neurochemistry, 116(1), 144-153. PMID: 21054389 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083853/ PMC4083853] DOI: 10.1111/j.1471-4159.2010.07092.x</ref> <ref>Freitas, I. N., da Silva Jr, J. A., Oliveira, K. M. D., Lourençoni Alves, B., Dos Reis Araújo, T., Camporez, J. P., ... & Davel, A. P. (2023). Insights by which TUDCA is a potential therapy against adiposity. Frontiers in Endocrinology, 14, 1090039. PMID: 36896173 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989466/ PMC9989466] DOI: 10.3389/fendo.2023.1090039</ref>

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