From Longevity Wiki

Amplify, daily supplement from longevity company Tally Health, aims to revitalize energy levels, enhance metabolism and boost muscle function.[1] Amplify’s ingredients include:

Glycine, 1000mg: The primary ingredient of Amplify, glycine has been extensively studied for its ability to prolong life and enhance health. Glycine helps tackle aging by clearing out old molecular junk and harmful molecules from our cells.[2]

Berberine, 600mg: Berberine works to balance blood sugar levels and support healthy metabolic function by activating AMPK, a pro-longevity energy sensor in our cells. This compound plays a crucial role in reprogramming metabolism as it mitigates high glucose levels.[3]

Urolithin A, 250mg: Urolithin A enhances mitochondrial efficiency and energy production by selectively recycling dysfunctional mitochondria, a process known as mitophagy. Urolithin A has also been shown to elevate levels of NAD+ (nicotinamide adenine dinucleotide)[4] and augment muscle function and physical performance.[5][6]


  1. Garth E. (2023). Consumer longevity company Tally launches new daily supplement. Longevity.Technology. Supplements.
  2. Johnson, A. A., & Cuellar, T. L. (2023). Glycine and aging: Evidence and mechanisms. Ageing Research Reviews, 101922. PMID: 37004845 DOI: 10.1016/j.arr.2023.101922
  3. Och, A., Podgórski, R., & Nowak, R. (2020). Biological activity of berberine—A summary update. Toxins, 12(11), 713. PMID: 33198257 PMC7697704 DOI: 10.3390/toxins12110713
  4. Ghosh, N., Das, A., Biswas, N., Gnyawali, S., Singh, K., Gorain, M., ... & Sen, C. K. (2020). Urolithin A augments angiogenic pathways in skeletal muscle by bolstering NAD+ and SIRT1. Scientific Reports, 10(1), 1-13. PMID: 33214614 PMC7678835 DOI: 10.1038/s41598-020-76564-7
  5. Singh, A., D’Amico, D., Andreux, P. A., Fouassier, A. M., Blanco-Bose, W., Evans, M., ... & Rinsch, C. (2022). Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine, 3(5). PMID: 35584623 PMC9133463 DOI: 10.1016/j.xcrm.2022.100633
  6. Liu, S., D’Amico, D., Shankland, E., Bhayana, S., Garcia, J. M., Aebischer, P., ... & Marcinek, D. J. (2022). Effect of urolithin A supplementation on muscle endurance and mitochondrial health in older adults: a randomized clinical trial. JAMA network open, 5(1), e2144279-e2144279. PMID: 35050355 PMC8777576 DOI: 10.1001/jamanetworkopen.2021.44279