Lepodisiran: Revision history

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14 November 2023

  • curprev 12:5012:50, 14 November 2023‎ Dmitry Dzhagarov talk contribs‎ 2,335 bytes +2,335‎ Created page with "'''Lepodisiran''' is a small interfering RNA (siRNA) that disables messenger RNA involved in producing apolipoprotein(a), a component essential for the assembly of lipoprotein(a) (Lp(a)) particles that is synthesized in the liver. The drug is a Dicer substrate short interfering RNA with a tetraloop structure attached to the sugar N-Acetylgalactosamine (GalNAc), which allows it to be carried into liver cells possessing GalNAc receptors. <ref name="Short" >Nissen SE, Linne..."
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