User contributions for Dmitry Dzhagarov

12:3612:36, 21 September 2024 diff hist −223‎ Calcium channel blockers (CCBs) ‎ →‎Cinnarizine current Tag: Visual edit: Switched
10:4510:45, 21 September 2024 diff hist +25‎ m SLIT2 ‎No edit summary current Tag: Visual edit: Switched
10:4110:41, 21 September 2024 diff hist +25‎ m Menin ‎No edit summary current Tag: Visual edit: Switched
10:3610:36, 21 September 2024 diff hist +25‎ ATF4 (activating transcription factor 4) ‎No edit summary current Tag: Visual edit: Switched
10:3410:34, 21 September 2024 diff hist +1,811‎ N Role of JNK in aging ‎ Created page with "'''JNK (c-Jun N-terminal kinase)''' is a crucial signaling pathway that plays a significant role in normal physiological processes. The JNK signaling pathway exhibits a dual nature during the aging process. For instance, when JNK is activated in the brain, it leads to a prolonged lifespan, whereas moderate activation of JNK in midgut intestinal stem cells (ISCs) and enteroblasts significantly shortens lifespan.<ref>Gan, T., Fan, L., Zhao, L., Misra, M., Liu, M., Zhang, M..." current

18:5718:57, 13 September 2024 diff hist +930‎ N OSER1 gene ‎ Created page with "'''OSER1 (Oxidative stress-responsive serine-rich protein 1)''' is an evolutionarily conserved '''FOXO-regulated protein''' that improves resistance to oxidative stress, maintains mitochondrial functional integrity, and increases lifespan in multiple species. OSER1 overexpression extends lifespan in silkworms, nematodes, and flies, while its depletion correspondingly shortens lifespan. Human proteomic analysis suggests that OSER1 plays roles in o..." current
18:5618:56, 13 September 2024 diff hist +23‎ FOXO longevity genes ‎ →‎FOXO in aging and longevity Tag: Visual edit: Switched

18:1118:11, 1 September 2024 diff hist +2,015‎ Preventing muscle loss ‎No edit summary current Tag: Visual edit: Switched
13:0113:01, 1 September 2024 diff hist +30‎ Preventing muscle loss ‎ →‎Plant-derived bioactive compounds beneficial in preventing muscle loss and restoring muscle function Tag: Visual edit: Switched
12:5912:59, 1 September 2024 diff hist +3,107‎ N Preventing muscle loss ‎ Created page with "'''Preventing muscle loss''' Skeletal muscle atrophy is characterized by weakening, shrinking, and decreasing muscle mass and fiber cross-sectional area at the histological level. It manifests as a reduction in force production, easy fatigue and decreased exercise capability, along with a lower quality of life. '''Exercise''' is widely acknowledged as '''the most effective therapy for skeletal muscle atrophy'''; unfortunately, it is not applicable for all patients. Sev..."

19:3519:35, 25 August 2024 diff hist +464‎ Granzyme B ‎No edit summary current Tag: Visual edit: Switched
19:2219:22, 25 August 2024 diff hist +22‎ m Granzyme B ‎No edit summary Tag: Visual edit: Switched
19:2119:21, 25 August 2024 diff hist +927‎ N Granzyme B ‎ Created page with "'''Granzymes''', a family of serine proteases with intracellular cytotoxic and/or proinflammatory functions, are increasingly recognized for their emerging roles in biological aging and disease. Widely recognized as intracellular mediators of cell death, granzymes, particularly '''granzyme B (GzmB)''' is observed in numerous age-related conditions, also accumulate in the extracellular milieu of tissues with age, contributing to chronic tissue injury, inflammation, and i..."
18:2818:28, 25 August 2024 diff hist +23‎ m Small nucleoli as a visible cellular hallmark of longevity and metabolic health ‎ →‎SNORA13 current Tag: Visual edit: Switched

17:3917:39, 15 August 2024 diff hist +2,170‎ N Seno-protective benefits of tropoelastin ‎ Created page with "Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.<ref>Shek, N., Choy, A. M., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., ... & Huang, J. T. (2024). Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. npj Aging, 10(1), 15. PMID: 38413600 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10899634/ PMC10899634] DOI: 10.1038/s41514-024-00143-7</ref> "... Ultra-..." current
16:1416:14, 15 August 2024 diff hist +418‎ Calcium channel blockers (CCBs) ‎ →‎Cinnarizine Tag: Visual edit: Switched
13:3813:38, 15 August 2024 diff hist +445‎ Calcium channel blockers (CCBs) ‎ →‎Cinnarizine Tag: Visual edit: Switched