Role of JNK in aging
JNK (c-Jun N-terminal kinase) is a crucial signaling pathway that plays a significant role in normal physiological processes. The JNK signaling pathway exhibits a dual nature during the aging process. For instance, when JNK is activated in the brain, it leads to a prolonged lifespan, whereas moderate activation of JNK in midgut intestinal stem cells (ISCs) and enteroblasts significantly shortens lifespan.[1] JNK demonstrates the ability to diminish telomerase reverse transcriptase activity, elevate β-galactosidase activity, and induce telomere shortening, thereby contributing to immune system aging. [2]
Studies in mice suggest that mammalian JNK exerts widespread and context-dependent effects in models of aging and diseases.[2]
JNK inhibitors
JNK inhibitors hold the potential to delay aging and treat age-associated conditions. Notable examples of JNK inhibitors include SP600125, CC-930, CC-401, CC-90001, and CEP-1347.[2]
References
- ↑ Gan, T., Fan, L., Zhao, L., Misra, M., Liu, M., Zhang, M., & Su, Y. (2021). JNK signaling in Drosophila aging and longevity. International Journal of Molecular Sciences, 22(17), 9649. PMID: 34502551 PMC8431792 DOI: 10.3390/ijms22179649
- ↑ 2.0 2.1 2.2 Li, Y., You, L., Nepovimova, E., Adam, V., Heger, Z., Jomova, K., ... & Kuca, K. (2024). c-Jun N-terminal kinase signaling in aging. Frontiers in Aging Neuroscience, 16, 1453710. PMID: 39267721 PMC11390425 DOI: 10.3389/fnagi.2024.1453710
