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Senolytics are a novel class of drugs that clear senescent cells (SCs) from the body that are implicated in aging. SCs not only accumulate with aging, but also play a fundamental role in aging and age-related diseases; removal of such cells confers substantial benefit in healthspan and lifespan in animal models of premature aging and normal aging.
SCs are responsible for generating the senescence-associated secretory phenotype (SASP), which have been shown to drive tissue dysfunction in a large range of organ systems.
Types of senolytics
Dasatinib + Quercetin
Dasatinib and Quercertin are a specific combination of medicines (D+Q) used for senescent cell clearance, which began from research in the Mayo Clinic.
Fisetin is a naturally-occurring flavonoid that is rich in certain fruits and vegetables, such as strawberries, grapes, apples, cucumbers, and onions. It has known antioxidant activity and is a supplement that is regarded as safe, even at high doses.