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Senolytics are a novel class of drugs that aim to clear senescent cells (SCs) from the body.
SCs are known to accumulate with aging, and might play a fundamental role in aging and age-related diseases. SCs are responsible for secreting the senescence-associated secretory phenotype (SASP) molecule, which has been linked to organismal dysfunction.
Removal of SCs can improve healthspan and lifespan in animal models of premature aging and normal aging. However, some studies suggest that SCs play a fundamental role in physiology and their removal via senolytics or other methods might have deleterious effects in vivo.
Dasatinib + Quercetin
Dasatinib and Quercertin are a specific combination of medicines (D+Q) used for senescent cell clearance, which began from research in the Mayo Clinic.
Fisetin is a naturally-occurring flavonoid that is rich in certain fruits and vegetables, such as strawberries, grapes, apples, cucumbers, and onions. It has known antioxidant activity and is a supplement that is regarded as safe, even at high doses.
- van Deursen JM. The role of senescent cells in ageing. Nature. 2014 May 22;509(7501):439-46. doi: 10.1038/nature13193. PMID: 24848057; PMCID: PMC4214092.
- Born, E. et al. (2022) “Eliminating senescent cells can promote pulmonary hypertension development and progression,” Circulation[Preprint]. Available at: https://doi.org/10.1161/circulationaha.122.058794.