Cellular senescence

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Cellular senescence is one of the hallmarks of aging.

Mechanism

Question to writers: Cellular senescence seems to have a positive function in our bodies - what is that? How does it become dangerous? It seems like it is "a normally adaptive response to injury or infection". Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941545/

Senescent cells secrete a phenotype, appropriately called senescence-associated secretory phenotype (SASP), which releases various factors that cause inflammation and dysfunction and promotes apoptosis (cell death) in nearby tissues.


Source references are needed for all of the above, for example:

https://brain.forever-healthy.org/display/EN/Dasatinib+and+Quercetin+Senolytic+Therapy

Diseases associated with cellular senescence

Due to the SASP, senescent cells have been associated with a number of age-related diseases:

*Fibrotic Pulmonary Disease: https://pubmed.ncbi.nlm.nih.gov/28230051/

Senolytics

See the full article on senolytics.

Senescent cells survive their own SASP, since they are protected by networks of senescent cell anti-apoptotic pathways (SCAPs). One method of senolytics, therefore, is to interfere with these networks, so that the SASP also induce apoptosis in the senescent cells themselves.

Senescent cells take time to re-build once they are ablated. Hence, an advantage of senolytic treatment is that it can be done in a "hit-and-run" fashion, thus avoiding off-target effects in comparison to other types of treatments.

A way to track if senolytics have any effect is to check out for senescent biomarkers. It seems like p16, p21 and senescence-associated β-galactosidase activity (SA-β-gal) are known markers of senescent cells.

Writers: Make sure to sync this article with senolytics.

Source references are needed for all of the above, see for example the three human clinical trial studies in the article on dasatinib.

Negligible senescence

See the full article on negligible senescence.

The phenomenon of showing no signs of senescence, such as age-related dysfunctions (Wikipedia).