Pigment epithelium-derived factor (PEDF)

Pigment epithelium-derived factor (PEDF) is a 50 kDa secreted glycoprotein that belongs to the non-inhibitory group of the serine protease inhibitor (SERPIN) superfamily.^[1] PEDF plays an important role in mediating cellular protection during exposure to oxidative stress and inflammation by preventing stress-induced angiogenesis and apoptosis.^[2] PEDF is the most potent anti-angiogenic agent currently known, twice as potent as angiostatin.^[3]

^[4]

References

↑ Filleur, S., Nelius, T. I. O. V. S., De Riese, W., & Kennedy, R. C. (2009). Characterization of PEDF: a multi‐functional serpin family protein. Journal of cellular biochemistry, 106(5), 769-775. https://doi.org/10.1002/jcb.22072
↑ Brook, N., Brook, E., Dharmarajan, A., Chan, A., & Dass, C. R. (2019). The role of pigment epithelium-derived factor in protecting against cellular stress. Free Radical Research, 53(11–12), 1166–1180. https://doi.org/10.1080/10715762.2019.1697809
↑ Li, R., Weng, X., Hu, X., Wang, J., & Zheng, L. (2024). Pigment epithelium‑derived factor inhibits proliferation, invasion and angiogenesis, and induces ferroptosis of extravillous trophoblasts by targeting Wnt‑β‑catenin/VEGF signaling in placenta accreta spectrum. Molecular Medicine Reports, 29(5), 1-10. PMID: 38488028 PMC10975022 DOI: 10.3892/mmr.2024.13199
↑ Wang X., Tazearslan C., Kim S., et al., (2024). In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood. bioRxiv.592258; doi: https://doi.org/10.1101/2024.05.02.592258

[1] Filleur, S., Nelius, T. I. O. V. S., De Riese, W., & Kennedy, R. C. (2009). Characterization of PEDF: a multi‐functional serpin family protein. Journal of cellular biochemistry, 106(5), 769-775. https://doi.org/10.1002/jcb.22072

[2] Brook, N., Brook, E., Dharmarajan, A., Chan, A., & Dass, C. R. (2019). The role of pigment epithelium-derived factor in protecting against cellular stress. Free Radical Research, 53(11–12), 1166–1180. https://doi.org/10.1080/10715762.2019.1697809

[3] Li, R., Weng, X., Hu, X., Wang, J., & Zheng, L. (2024). Pigment epithelium‑derived factor inhibits proliferation, invasion and angiogenesis, and induces ferroptosis of extravillous trophoblasts by targeting Wnt‑β‑catenin/VEGF signaling in placenta accreta spectrum. Molecular Medicine Reports, 29(5), 1-10. PMID: 38488028 PMC10975022 DOI: 10.3892/mmr.2024.13199

[4] Wang X., Tazearslan C., Kim S., et al., (2024). In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood. bioRxiv.592258; doi: https://doi.org/10.1101/2024.05.02.592258

[1]

[2]

[3]

[4]