View source for Pigment epithelium-derived factor (PEDF)

'''Pigment epithelium-derived factor (PEDF)''' is a 50 kDa secreted glycoprotein that belongs to the non-inhibitory group of the serine protease inhibitor (SERPIN) superfamily.<ref>Filleur, S., Nelius, T. I. O. V. S., De Riese, W., & Kennedy, R. C. (2009). Characterization of PEDF: a multi‐functional serpin family protein. Journal of cellular biochemistry, 106(5), 769-775. https://doi.org/10.1002/jcb.22072</ref> PEDF plays an important role in mediating cellular protection during exposure to oxidative stress and inflammation by preventing stress-induced angiogenesis and apoptosis.<ref>Brook, N., Brook, E., Dharmarajan, A., Chan, A., & Dass, C. R. (2019). The role of pigment epithelium-derived factor in protecting against cellular stress. Free Radical Research, 53(11–12), 1166–1180. https://doi.org/10.1080/10715762.2019.1697809</ref>
PEDF is the most potent anti-angiogenic agent currently known, twice as potent as angiostatin.<ref>Li, R., Weng, X., Hu, X., Wang, J., & Zheng, L. (2024). Pigment epithelium‑derived factor inhibits proliferation, invasion and angiogenesis, and induces ferroptosis of extravillous trophoblasts by targeting Wnt‑β‑catenin/VEGF signaling in placenta accreta spectrum. Molecular Medicine Reports, 29(5), 1-10. PMID: 38488028 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10975022/ PMC10975022] DOI: 10.3892/mmr.2024.13199</ref>

<ref>Wang X., Tazearslan C., Kim S., et al., (2024). In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood. bioRxiv.592258; doi: https://doi.org/10.1101/2024.05.02.592258</ref>

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