Non-Genomic Hallmarks of Aging
The hallmarks of aging can be divided into genomic hallmarks (closely related to DNA) and non-genomic hallmarks. Genomic hallmarks include genomic instability, telomere attrition and epigenetic alterations. Non-genomic hallmarks include cellular senescence, loss of proteostasis, deregulated nutrient sensing, altered intercellular communication, immune system dysfunction and chronic inflammation, stem cell exhaustion, mitochondrial dysfunction and dysbiosis.
Deregulated Nutrient Sensing
Immune System Dysfunction
Stem Cell Exhaustion
- Holmannova, D., Borsky, P., Parova, H., Stverakova, T., Vosmik, M., Hruska, L., ... & Borska, L. (2023). Non-Genomic Hallmarks of Aging—The Review. International Journal of Molecular Sciences, 24(20), 15468. https://doi.org/10.3390/ijms242015468