Non-Genomic Hallmarks of Aging

From Longevity Wiki

The hallmarks of aging can be divided into genomic hallmarks (closely related to DNA) and non-genomic hallmarks. Genomic hallmarks include genomic instability, telomere attrition and epigenetic alterations. Non-genomic hallmarks include cellular senescence, loss of proteostasis, deregulated nutrient sensing, altered intercellular communication, immune system dysfunction and chronic inflammation, stem cell exhaustion, mitochondrial dysfunction and dysbiosis.[1]



Deregulated Nutrient Sensing

Intercellular Communication

Immune System Dysfunction

Stem Cell Exhaustion

Mitochondrial Dysfunctions


  1. Holmannova, D., Borsky, P., Parova, H., Stverakova, T., Vosmik, M., Hruska, L., ... & Borska, L. (2023). Non-Genomic Hallmarks of Aging—The Review. International Journal of Molecular Sciences, 24(20), 15468.